06:43pm Tuesday 18 February 2020

Lie diet-tector: how scientists can reveal the truth about what you eat

What we eat has a big impact on our health but it is very difficult measure exactly what, and how much, people eat in everyday life – and people find it difficult to record honestly. Measuring what people eat can help prevent illness by showing definite links between particular kinds, and amounts, of foods and specific diseases.

By testing urine for the chemical ‘fingerprints’ of different foods, the scientists at Newcastle and Aberystwyth Universities demonstrated that they could determine whether individuals are eating healthy diets or not. The chemical ‘fingerprints’ they identified are substances called metabolites which are unique to different foodstuffs – those for healthy foods such as raspberries, salmon, broccoli and orange juice have already been  identified.

The next stage for the scientists is to develop a simple test with the potential to revolutionise health care by determining whether people are eating a healthy diet or not.

The new test is being developed by Professor John Mathers and his team in the Human Nutrition Research Centre (HNRC) at Newcastle University and Professor John Draper and colleagues at IBERS (the Institute of Biological, Environmental and Rural Sciences) at Aberystwyth University.
The scientists believe the test will even be able to distinguish between similar foods such as whether someone has eaten red, white or processed meat and so help in understanding links between these foods and health.

“This kind of test has enormous potential as a weapon against many chronic diseases,” said Professor John Draper who is leading the work at Aberystwyth.

“It will help doctors, nurses, dieticians and nutritionists to work out what their patients have been eating.”

Newcastle University’s Professor Mathers added; “In the longer run, this kind of test will help to uncover new links between eating patterns and health.

“As our knowledge about metabolite markers of other foods grows, we will be able to add these to our test and it should mean that researchers will be able to say for certain which foods help protect against specific diseases and which we should encourage to promote better health.”

The longer term aim of the research is to develop a simple dipstick test – a sensor dipped into urine which will provide an instant readout of the main foods that the person has eaten.

References: FAVE G, BECKMANN M, LLOYD AJ, ZHOU S, HAROLD G, LIN W, TAILLART K, XIE, L, DRAPER J, MATHERS JC (2011) Metabolomics7, 469-484. Development and validation of a standardised protocol to monitor human dietary exposure by metabolite fingerprinting of urine samples.

LLOYD AJ, FAVE G, BECKMANN M, LIN W, TAILLIART K, XIE L, MATHERS JC, DRAPER J (2011) American Journal of Clinical Nutrition94, 981-991. ‘Use of mass spectrometry fingerprinting to identify urinary metabolites after consumption of specific foods.’

LLOYD AJ, BECKMANN M, FAVE G, MATHERS JC, DRAPER J (2011) British Journal of Nutrition106, 812-824. ‘Prolinebetaine and its biotransformation products in fasting urine samples are potential biomarkers of habitual citrus fruit consumption.’


published on: 11th January 2012

Key Facts:

  • Newcastle University is a Russell Group University
  • We ranked 12th in The Sunday Times 2011 Survey
  • Amongst our peers in 2011 Newcastle is ranked:
    • 5th in the UK for employability of its graduates
    • 10th in the UK for student satisfaction
    • In the UK’s top 12 for research power in Science and Engineering
  • We have a world-class reputation for research excellence and are spearheading three major societal challenges that have a significant impact on global society. These themes are: Ageing and Health, Sustainability, and Social Renewal
  • Newcastle University is the first UK university to establish a fully owned international branch campus for medicine at its NUMed Campus in Malaysia which opened in 2011

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