Cyclists were recruited to exclude the effects of a sedentary lifestyle, which can aggravate health problems and cause changes in the body, which might appear to be due to the ageing process. Men and women had to be able to cycle 100 km in under 6.5 hours and 60 km in 5.5 hours, respectively, to be included in the study. Smokers, heavy drinkers and those with high blood pressure or other health conditions were excluded from the study.
Participants underwent two days of laboratory testing at King’s. For each participant, a physiological profile was established which included measures of cardiovascular, respiratory, neuromuscular, metabolic, endocrine and cognitive functions, bone strength, and health and well-being. Volunteers’ reflexes, muscle strength, oxygen uptake during exercise and peak explosive cycling power were determined.
The results of the study showed that in these individuals, the effects of ageing were far from obvious. Indeed, people of different ages could have similar levels of function such as muscle strength, lung power and exercise capacity. The maximum rate of oxygen consumption showed the closest association with age, but even this marker could not identify with any degree of accuracy the age of any given individual, which would be the requirement for any useful biomarker of ageing.
In a basic, but important test of function in older people, the time taken to stand from a chair, walk three metres, turn, walk back and sit down was also measured. Taking more than 15 seconds to complete the task generally indicates a high risk of falling. Even the oldest participants in the present study fell well below these levels, fitting well within the norm for healthy young adults.
Overall, the study concluded that ageing is likely to be a highly individualist phenomenon. As people are so different, the team concluded that more studies are needed which follow the same healthy and exercising individuals over time to better understand the effects of ageing the body.
Dr Ross Pollock, lead author of the paper from King’s College London, said: “An essential part of our study was deciding which volunteers should be selected to explore the effects of ageing. The main problem facing health research is that in modern societies the majority of the population is inactive. A sedentary lifestyle causes physiological problems at any age. Hence the confusion as to how much the decline in bodily functions is due to the natural ageing process and how much is due to the combined effects of ageing and inactivity.”
“In many models of ageing lifespan is the primary measure, but in human beings this is arguably less important than the consequences of deterioration in health. Healthy life expectancy – our healthspan – is not keeping pace with the average lifespan, and the years we spend with poor health and disabilities in old age are growing.”
Professor Stephen Harridge, senior author and Director of the Centre of Human & Aerospace Physiological Sciences at King’s College London where the study took place, said: “Because most of the population is largely sedentary, the tendency is to assume that inactivity is the inevitable condition for humans. However, given that our genetic inheritance stems from a period when high levels of physical activity were the likely norm, being physically active should be considered to play an essential role in maintaining health and wellbeing throughout life.”
Emeritus Professor Norman Lazarus, a member of the King’s team and also a cyclist, said: “Inevitably, our bodies will experience some decline with age, but staying physically active can buy you extra years of function compared to sedentary people. Cycling not only keeps you mentally alert, but requires the vigorous use of many of the body’s key systems, such as your muscles, heart and lungs which you need for maintaining health and for reducing the risks associated with numerous diseases.”
Notes to editor
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An investigation into the relationship between age and physiological function in highly active older adults, by Pollock RD, Carter S, Velloso CP, Duggal NA, Lord JM, Lazaraus NR, Harridge SDR, is published online in The Journal of Physiology on Tuesday 6 January 2015.
The study was funded by the BUPA Foundation.
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