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6 Best Glutamine Supplements, Powders Reviews 2022


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Medically reviewed by Dr G. Michael DiLeo, MD

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Transparent Labs BCAA Glutamine

Transparent Labs CoreSeries BCAA Glutamine

  • Branched-chain amino acids (BCAA) supplement.
  • For muscle growth.
  • Reduces fatigue.

Jacked Factory L-Glutamine Fermented

Jacked Factory L-Glutamine Fermented

  • Manufactured in Current Good Manufacturing Practice (cGMP) facility.
  • Support immunity.
  • Support gut health.

Onnit Glutamine Amino Acid

Onnit Glutamine Amino Acid

  • 3-rd party tested.
  • Soy and dairy-free.
  • Pure L-glutamine.

Proteins are among the many important nutrients for creating and maintaining the health of our bodies. A protein molecule can be broken down into smaller pieces; one of the proteins’ building blocks is glutamine.

Glutamine is commonly used in bulk supplements as L-glutamine. It helps with muscle mass growth and recovery, immune and cell modulation[1], gut health, immunity, and an energy boost during strenuous workouts.

This piece will highlight six of the best glutamine supplements you can find on sale. So, without further ado, let’s jump right into the definition of glutamine.

Best Glutamine Supplements For Bodybuilding on the market in (August. 2022)

What is Glutamine?

A crucial component of many bodily processes, glutamine is an amino acid and the building block of protein.

Although the body produces glutamine, it can also be found in many foods. People who eat various meals probably obtain enough of this amino acid daily. However, meat, tofu, and other animal products are where you can get glutamine most frequently (usually enough). Therefore, vegetarians or vegans who avoid soy might consider a glutamine supplement to increase consumption.

It is found in two different kinds: L-glutamine and D-glutamine.

L-glutamine breaks down the toxic products of metabolism. Research demonstrates beneficial effects on gut flora[2] and immune system maintenance[3]. Additionally, studies demonstrate it promotes recovery[4] after exercise.

Consult a doctor to determine whether including glutamine supplementation in your diet may be beneficial before choosing which of these L-glutamine supplements is best for you.

Who Should Take Glutamine Supplement?

As indicated above, including food sources[5] rich in glutamine (L-glutamine amino acid), you may not need to add glutamine capsules to your daily routine.

Vegans and vegetarians could benefit significantly from using glutamine powder or capsules, as they are eliminating some excellent sources for it, e.g., beef, chicken, and fish (for vegetarians), and–additionally–dairy products (for vegans). L-glutamine supplements will offer them a healthy supply of these essential amino acids.

Another group that can benefit significantly from the extra glutamine intake is athletes and gymgoers who want to add their lean muscle mass. They use these supplements as capsules and protein shake before or after working out. This maximizes the benefits of fighting fatigue after a workout, as well as a better immune system and better gut health.Glutamine also is an amino acid essential to deal with any metabolic stress[6]. People who have suffered severe burns[7] or undergone surgery[8] benefit from taking an L-glutamine supplement due to the reduction in infection risk[9], mitigating these high-risk scenarios.

The Line Up At A Glance

Transparent Labs BCAA Glutamine

Editor’s choice

Transparent Labs CoreSeries BCAA Glutamine

  • Branched-chain amino acids (BCAA) supplement.
  • For muscle growth.
  • Reduces fatigue.

Jacked Factory L-Glutamine Fermented

Best L-Glutamine Supplement for Gut Health

Jacked Factory L-Glutamine Fermented

  • Manufactured in Current Good Manufacturing Practice (cGMP) facility.
  • Support immunity.
  • Support gut health.

Onnit Glutamine Amino Acid

Best Glutamine Supplement for Athletes

Onnit Glutamine Amino Acid

  • 3-rd party tested.
  • Soy and dairy-free.
  • Pure L-glutamine.

Optimum Nutrition Glutamine Powder

Best Unflavoured Glutamine Supplement

Optimum Nutrition Glutamine Powder

  • Free shipping above $75.
  • Highly concentrated glutamine.
  • Great mixability.

Life Extension L-Glutamine

The Best Vegetarian Glutamine Capsules

Life Extension L-Glutamine 500mg

  • Genetically modified organism (GMO)-free.
  • Vegetarian friendly.
  • Gluten-free.

Naked Nutrition Glutamine Powder

Best Pre and Post-Workout Glutamine Supplement

Naked Nutrition Glutamine Powder

  • One ingredient formula.
  • Non-GMO.
  • Support workout endurance.

6 Best Glutamine Supplements For Bodybuilding in 2022  

Transparent Labs CoreSeries BCAA Glutamine

The BCAA supplement (with glutamine) boosts muscle growth, decreases fatigue and pain, and minimizes muscle atrophy. It enhances your health and performance by combining a great combination of glutamine with additional BCAA components

  • It helps with muscle development.
  • It may help you feel less tired after an intense workout.
  • The brand is certified in cGMP.
  • It has a 100% clean formula.
  • It contains Branched-chain amino acids (BCAAs)
  • It is only available on the brand site.
  • Mixing the powder thoroughly to get a seamless mix would be best.

Five grams of L-glutamine are contained in each scoop of this branched-chain amino acid (BCAA)-glutamine supplement. These all support muscle building. This product is also great for supporting muscle protein synthesis[10].

It has four grams of L-leucine, two grams of L-valine, and two grams of L-isoleucine in each serving, thus in a 2:1:1 ratio. Transparent Labs includes 1,535 milligrams of vitamin C and one gram of coconut water powder[11].

Natural flavor, citric acid, and stevia are additional ingredients. Transparent Labs’ glutamine dietary supplement differs noticeably from competitors’ in that each serving has only ten calories and 2 grams of carbohydrates.

There are five flavors to choose from: Lemonade, Orange, Strawberry, Sour Green Apple, and Blue Raspberry.

Jacked Factory L-Glutamine Fermented

Jacked Factory is a renowned brand with many supplements on the market. This fermented dietary protein is excellent for gut health, muscle recovery, energy, and immunity.

  • It helps optimize gut health.
  • It supports immune function.
  • It is ideal as a post-workout recovery L-glutamine powder.
  • It is unflavoured, making it perfect for protein shakes.
  • This supplement is manufactured as cGMP-certified
  • The lack of flavored options is a downside for some people.

The main thing that sets this brand apart is that its fermented glutamine is touted as being more bioavailable. Easier on the gut, its absorbability is increased tenfold. This means that the even smaller glutamine peptides that otherwise may pass through the digestive tract unabsorbed will get absorbed and used by the body. 

For this reason, it is the best L-glutamine powder supplement for leaky gut. (When a person has increased intestinal permeability[12] (IP), commonly referred to as a leaky gut, gaps develop in the barrier of the intestinal walls, affecting what can get into your system.)

What’s more impressive about this brand is that they only have one ingredient: pure L-glutamine (simplicity in function).

The L-Glutamine powder from Jacked Factory is unflavored, vegetarian, fermented, and mixes easily in just about any liquid. Sportspeople, bodybuilders, gym-goers, and fitness enthusiasts can benefit from the 5,000mg of pure glutamine in every serving.

This pure L-glutamine supplement aims to effectively reduce muscle soreness[13] and support gut health and post-workout recovery. L-glutamine is essential for maintaining muscle glycogen levels[14] before, during, and after a workout. It also serves as an integral component of skeletal muscle tissue.

This supplement lacks synthetic additives, including flavors, colors, and preservatives.

Onnit Glutamine Amino Acid

It keeps things simple, having only one ingredient: pure L-glutamine. Another notable benefit is having an NSF certification, documenting its absence of banned substances. This constant makes it best for athletes.

  • They have an Informed Sports certification.
  • This supplement is vegan-friendly.
  • It is also dairy- and soy-free.
  • You get a 10% discount on your first order.
  • It is third-party tested.
  • It supports recovery from muscle atrophy.
  • It supports gut health.
  • It has a 30-day money-back guarantee.
  • It is an expensive glutamine supplement.

Unlike most dietary supplements for muscle growth, Onnit Glutamine Amino Acid is stimulant-free. An ideal glutamine supplement for athletes, this supplement holds 60 servings.

A study conducted in 2015[15] discovered that athletes who took glutamine before running long distances saw less intestinal absorption of toxins, which eventually helped inhibit inflammatory pathways.

Glutamine can also help with response time, as a study[16] demonstrated how basketball players outperformed a control group by more than 12 percent after taking glutamine. Athletes had reported increased aerobic endurance even when their water balance was inadequate because glutamine can function as a fuel source for cells.

Additionally, it was discovered to reduce muscular soreness, hasten recovery after weight training, and even boost the immune system’s health.

Mix one scoop with 8 oz of your chosen beverage to get the best outcomes.

Optimum Nutrition Glutamine Powder

Optimum Nutrition Glutamine Powder considers itself a powerhouse when it comes to offering the best L-glutamine supplement. They purport that it offers superior supplementation of glutamine to the body.

  • It mixes well with both water and milk.
  • It is a highly concentrated powder, giving value for money.
  • It offers a 30-day money-back guarantee.
  • You get free shipping on orders above $75.
  • It may cause stomach upset.s item is high for some people

This L-glutamine powder benefits you, from optimizing your gut health to immunity-boosting and, finally, helping you with muscle development.

It has a clinically approved dose of 5,000mg of glutamine and is flavorless. You can mix it in water; mixing it into your smoothie or protein shake will not compromise the taste. This makes it the perfect supplement if you do not want the sweet, overbearing tastes typical of other amino acid supplements.

Users of this glutamine supplement have great things to say. The only critical review we saw was a case in which it caused the user an upset stomach. Such isolated cases are expected since people’s anatomies are different. Also, there are no certain ways to know whether a user is allergic or not.

Judging from the overwhelmingly positive reviews,  it’s evident that Optimum Nutrition Glutamine Powder is a brand many trusts.

Life Extension L-Glutamine 500mg

These vegetarian-friendly L-glutamine capsules can be used by men and women of all ages above 18.

  • It is gluten-free and non-GMO.
  • It is very affordable.
  • It is vegan-friendly.
  • It bolsters healthy muscle tissue.
  • It maintains energy levels under stress.
  • It maintains intestinal health and a healthy immune system.
  • You need to be on a healthy diet to use this product

L-glutamine, silica, vegetable stearate, rice flour, and stearic acid are all included in this dietary supplement (capsule).

The company is fairly certain that its vegetarian capsules will enhance immunity, mood, and muscles. They also promote their product as being perfect for athletes because it restores lost glutamine stores following exercise. An athlete’s immunity, disposition, and muscle growth are improved and sustained by this new supply.

Numerous sources that claim that this product works can be found on their website, and the customer testimonials are nothing short of stellar. Numerous articles about wellness utilizing the company’s supplements and other general news are available on the same website.

There are a variety of responses to the product on Amazon. While some customers claim it was successful for them, others express dissatisfaction. In several of the negative reviews, it was mentioned that the consumers had headaches, constipation, and their blood pressure had risen. 

However, the positive feedback that was left behind stated that it helped treat chronic digestive difficulties, it was effective for older users, and it decreased sugar cravings in others.

The manufacturer suggests that you take one capsule once or twice daily or as directed by your doctor for the best results.

Naked Nutrition Glutamine Powder

The Naked Nutrition Glutamine Powder supplement has only one ingredient. It offers benefits like workout endurance, better immunity, and mass muscle preservation.

  • This product only have one ingredient.
  • This supplement is vegan- and vegetarian-friendly.
  • Naked Nutrition Glutamine Powder offers users better endurance during intense exercise.
  • It helps you preserve muscle mass.
  • This glutamine supplement improves your overall health.
  • It contains soy and nuts.

This brand has received positive Internet reviews that have a wide range of remarks–about how simple it is to swallow, how great the packaging is, how high-quality the ingredients are, how efficient it is, and how delicious it tastes.

This supplement’s sugar comes from organic beets. It is described as pharmaceutical quality. It is an excellent L-glutamine supplement for weight loss because it contains no carbohydrates or fats. It also limits muscle catabolism[17], which is a reaction to stress.

All of the Naked brand’s goods, including this one, have undergone independent third-party testing, making it a very transparent company.

To maximize muscle preservation, mix glutamine with Naked’s creatine supplement for the best results.

This glutamine powder can be used by combining it with juice and sports drinks. The best times to use it are in the morning, right before going to sleep, or right after working out. One scoop is dissolved in 8 ounces of water, a sports drink, or a low-acid fruit juice. As the best pre-and post-workout supplement, you may drink it at any time of the day.

Benefits of Glutamine Supplement

Here are some of the notable benefits of nutrition supplements rich in glutamine:

What To Consider In The Best Glutamine Supplement

There are numerous glutamine powders and capsules on sale, so here is a checklist you may use to land the ideal glutamine supplements for you:

  • Visit a doctor to get a full medical assessment to confirm that L-glutamine supplements will work for you.
  • Consider your primary purpose of getting the L-glutamine dietary supplement: gut health, muscle soreness remedy, or immunity boost.
  • Check the certifications on the selected L-glutamine powder: NSF, Certification of Analysis, Organic, Vegan, and Non-GMO verifications.
  • Study the ingredient list, noting what the individual ingredients do according to scientific research.
  • Evaluate the cost of using the supplement long-term.


The form of the glutamine supplement will be the primary factor in determining the dosage. If it is a glutamine capsule, the dosage is determined by an individual pill intake. When it comes to glutamine powders, the maker of the brand typically provides a scooping spoon that is pre-calibrated to the appropriate dosage.

There is no universally applicable dose; instead, you should consult both the instructions provided by the manufacturer and your physician.


Every athlete looking for the best glutamine capsules and powders has undoubtedly come across at least one of the six brands we have brought to your attention.

However, consult with your healthcare provider and make sure to stick to the dosage that was suggested. Remember that for any of these six best glutamine supplements to work for you, you will also need to combine the glutamine with a nutritious diet and lead an active lifestyle.

Frequently Asked Questions

Can glutamine help me gain muscle?

Supplemental glutamine used to support muscle growth or strength performance is not widely studied. However, they might lessen discomfort or weariness during and after working out.

Is glutamine worth buying?

If your doctor gives you the go-ahead, it is a worthwhile investment. It boosts your immunity, you heal faster, and your gut health is also optimized.

What are the adverse effects of L-glutamine?

Hives, nausea, vomiting, and joint discomfort are some of the side effects. According to certain research, L-glutamine causes some cancer cell types to multiply quickly.

How much and how frequently should I take it?

The quantity and frequency of using glutamine powders or capsules are dependent on the manufacturer’s instructions.

+ 22 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Roth, E. (2008). Nonnutritive Effects of Glutamine. The Journal of Nutrition, [online] 138(10), pp.2025S2031S. doi:10.1093/jn/138.10.2025s.
  2. Kim, M.-H. and Kim, H. (2017). The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. International Journal of Molecular Sciences, [online] 18(5), p.1051. doi:10.3390/ijms18051051.
  3. Cruzat, V., Macedo Rogero, M., Noel Keane, K., Curi, R. and Newsholme, P. (2018). Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation. Nutrients, [online] 10(11), p.1564. doi:10.3390/nu10111564.
  4. Coqueiro, A.Y., Rogero, M.M. and Tirapegui, J. (2019). Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition. Nutrients, [online] 11(4), p.863. doi:10.3390/nu11040863.
  5. Lenders, C.M., Liu, S., Wilmore, D.W., Sampson, L., Dougherty, L.W., Spiegelman, D. and Willett, W.C. (2009). Evaluation of a novel food composition database that includes glutamine and other amino acids derived from gene sequencing data. European Journal of Clinical Nutrition, [online] 63(12), pp.1433–1439. doi:10.1038/ejcn.2009.110.
  6. Windle, E.M. (2006). Glutamine Supplementation in Critical Illness: Evidence, Recommendations, and Implications for Clinical Practice in Burn Care. Journal of Burn Care & Research, [online] 27(6), pp.764–772. doi:10.1097/01.bcr.0000245417.47510.9c.
  7. Lin, J.-J., Chung, X.-J., Yang, C.-Y. and Lau, H.-L. (2013). A meta-analysis of trials using the intention to treat principle for glutamine supplementation in critically ill patients with burn. Burns, [online] 39(4), pp.565–570. doi:10.1016/j.burns.2012.11.008.
  8. Vijey Aanandhi Muthukumar and Meha Rachel John (2017). Enteral/oral glutamine supplementation in patients following surgery and accidental injury. [online] ResearchGate. Available at: https://www.researchgate.net/publication/316634007_Enteraloral_glutamine_supplementation_in_patients_following_surgery_and_accidental_injury
  9. Lin, J.-J., Chung, X.-J., Yang, C.-Y. and Lau, H.-L. (2013). A meta-analysis of trials using the intention to treat principle for glutamine supplementation in critically ill patients with burn. Burns, [online] 39(4), pp.565–570. doi:10.1016/j.burns.2012.11.008.
  10. Jackman, S.R., Witard, O.C., Philp, A., Wallis, G.A., Baar, K. and Tipton, K.D. (2017). Branched-Chain Amino Acid Ingestion Stimulates Muscle Myofibrillar Protein Synthesis following Resistance Exercise in Humans. Frontiers in Physiology, [online] 8. doi:10.3389/fphys.2017.00390.
  11. Saat, M., Singh, R., Sirisinghe, R.G. and Nawawi, M. (2002). Rehydration after Exercise with Fresh Young Coconut Water, Carbohydrate-Electrolyte Beverage and Plain Water. Journal of PHYSIOLOGICAL ANTHROPOLOGY and Applied Human Science, [online] 21(2), pp.93–104. doi:10.2114/jpa.21.93.
  12. Campos, M. (2017). Leaky gut: What is it, and what does it mean for you? – Harvard Health. [online] Harvard Health. Available at: https://www.health.harvard.edu/blog/leaky-gut-what-is-it-and-what-does-it-mean-for-you-2017092212451
  13. Legault, Z., Bagnall, N. and Kimmerly, D.S. (2015). The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise. International Journal of Sport Nutrition and Exercise Metabolism, [online] 25(5), pp.417–426. doi:10.1123/ijsnem.2014-0209.
  14. Coqueiro, A.Y., Rogero, M.M. and Tirapegui, J. (2019). Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition. Nutrients, [online] 11(4), p.863. doi:10.3390/nu11040863.
  15. Zuhl, M., Dokladny, K., Mermier, C., Schneider, S., Salgado, R. and Moseley, P. (2014). The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells. Cell Stress and Chaperones, [online] 20(1), pp.85–93. doi:10.1007/s12192-014-0528-1.
  16. Davidpublisher.com. (2015). Glutamine Supplementation and Basketball Players Power Performance Changes-David Publishing Company. [online] Available at: http://www.davidpublisher.com/index.php/Home/Article/index?id=23717.html
  17. Wolfe, R.R. (2005). Regulation of skeletal muscle protein metabolism in catabolic states. Current Opinion in Clinical Nutrition and Metabolic Care, [online] 8(1), pp.61–65. doi:10.1097/00075197-200501000-00009.
  18. Legault, Z., Bagnall, N. and Kimmerly, D.S. (2015). The Influence of Oral L-Glutamine Supplementation on Muscle Strength Recovery and Soreness Following Unilateral Knee Extension Eccentric Exercise. International Journal of Sport Nutrition and Exercise Metabolism, [online] 25(5), pp.417–426. doi:10.1123/ijsnem.2014-0209.
  19. Carvalho-Peixoto, J., Alves, R. and Cameron, L.-C. (2007). Glutamine and carbohydrate supplements reduce ammonemia increase during endurance field exercise. Applied Physiology, Nutrition, and Metabolism, [online] 32(6), pp.1186–1190. doi:10.1139/h07-091.
  20. Song, Q.-H., Xu, R.-M., Zhang, Q.-H., Shen, G.-Q., Ma, M., Zhao, X.-P., Guo, Y.-H. and Wang, Y. (2015). Glutamine supplementation and immune function during heavy load training. Int. Journal of Clinical Pharmacology and Therapeutics, [online] 53(05), pp.372–376. doi:10.5414/cp202227.
  21. Wang, B., Wu, G., Zhou, Z., Dai, Z., Sun, Y., Ji, Y., Li, W., Wang, W., Liu, C., Han, F. and Wu, Z. (2014). Glutamine and intestinal barrier function. Amino Acids, [online] 47(10), pp.2143–2154. doi:10.1007/s00726-014-1773-4.
  22. Fan, Y., Yu, J., Kang, W. and Zhang, Q. (2009). Effects of Glutamine Supplementation on Patients Undergoing Abdominal Surgery. Chinese Medical Sciences Journal, [online] 24(1), pp.55–59. doi:10.1016/s1001-9294(09)60060-2.

Medically reviewed by:

G. Michael DiLeo

Mitchelle Morgan is a health and wellness writer with over 10 years of experience. She holds a Master's in Communication. Her mission is to provide readers with information that helps them live a better lifestyle. All her work is backed by scientific evidence to ensure readers get valuable and actionable content.

Medically reviewed by:

G. Michael DiLeo

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