Top 8 Best Nitric Oxide Boosters On The Market 2022

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Medically reviewed by Kathy Shattler, MS, RDN

CrazyBulk’s NO2 Max

  • Increase energy and endurance
  • Free shipping & money-back guarantee
  • Fast results with no crash

Transparent Labs BULK Pre-Workout

Transparent Labs BULK

  • Evidence-based ingredients
  • No artificial ingredients
  • Supports lean muscle and testosterone

N.O. X.T. Jacked Factory

  • Money-back guarantee
  • Affordable
  • Science-backed dosage

Nitric Oxide is becoming more and more popular in the athletic industry. This supplement can speed up muscle growth and blood flow to help those intense muscles pump. Increasing nitric oxide levels will enhance overall workout performance.

Top 8 Best Nitric Oxide Supplements List (July. 2022)

  1. CrazyBulk’s NO2 Max – Editor’s choice
  2. Transparent Labs BULK – Best Pre-workout
  3. N.O. X.T. Jacked Factory – Best Nitric Oxide Pills
  4. Onnit Total Nitric Oxide– Most Affordable
  5. Huge Nutrition Magnify – Most Advanced Formula
  6. BlueEarth’s L-Arginine + L-Citrulline – Best Science-backed ingredients
  7. Snap Nitric Oxide Organic Beets – Best Natural Supplement
  8. Pump Serum Targeted for Men

What is Nitric Oxide?

Nitric Oxide is a molecule produced naturally within the body that can be increased through dietary supplements. These supplements help dilate blood vessels, allowing blood flow and controlling healthy blood pressure levels.

Additionally, it is an essential factor for your immune system. Nitric oxide can be consumed naturally in foods like spinach, carrots, beetroot, and cauliflower. 

Are Nitric Oxide Supplements Safe?

Is this supplement too good to be true? Is it safe to consume? Nitric oxide supplements are generally safe. However, there is a risk of mild side effects with any supplement. Some individuals have experienced stomach discomfort and headaches. You must take the product as directed by the manufacturer for it to operate optimally.

Additionally, as mentioned above, you can naturally get nitric oxide benefits through your diet. So if you have any unwanted side effects with dietary supplements, then increased dietary intake is the best route to go.

The Line Up At A Glance

crazybulk-no2-max

Editor’s choice

CrazyBulk’s NO2 Max

  • Increase energy and endurance
  • Free shipping & money-back guarantee
  • Fast results with no crash

Transparent Labs BULK Pre-Workout

Best Pre-workout

Transparent Labs BULK

  • Evidence-based ingredients
  • No artificial ingredients
  • Supports lean muscle and testosterone

NO-XT-jacked-factory

Best Nitric Oxide Pills

N.O. X.T. Jacked Factory

  • Money-back guarantee
  • Affordable
  • Science-backed dosage

Onnit Total Nitric Oxide

Most Affordable

Onnit Total Nitric Oxide

  • Helps build muscle
  • Fights fatigue
  • Stimulant-free

Huge Nutrition Magnify

Most Advanced Formula

Huge Nutrition Magnify

  • Scientifically based ingredients
  • Made in the United States
  • Intense muscle pumps

L-arginine l-citrulline

Best Science-backed ingredients

BlueEarth’s L-Arginine + L-Citrulline

  • Cardio health fórmula
  • Affordable
  • Science-backed ingredients

Snap Nitric Oxide Organic Beets

Best Natural Supplement

Snap Nitric Oxide Organic Beets

  • Aids cardiovascular health
  • Non-GMO & Vegan
  • Supports blood vessel health

pump serum

Targeted for Men

Pump Serum

  • Caffeine-free
  • Made in the United States
  • Helps with focus & endurance


Top 8 Best Nitric Oxide Supplements of 2022

Crazy Bulk NO2 Max

crazybulk-no2-max

This premium nitric oxide booster is formulated to improve blood flow and oxygen circulation during your workout. You should notice a significant difference in muscle pumps, increased energy levels, and excellent recovery.

  • Increases energy and strength
  • Free worldwide shipping
  • Results with no crash
  • Expensive

NO2 Max is a safe and legal nitric oxide supplement that targets overall muscle growth. While boosting your nitric oxide levels, this supplement promises to increase energy and endurance, provide long-lasting results with no crash, and help with gaining strength. 

This supplement is used by taking two tablets with water about twenty minutes prior to your workout. You should take it in conjunction with a healthy diet and exercise program targeted for muscle growth for maximum results.

The main ingredients found in NO2 Max are L-arginine alpha-ketoglutarate and calcium. Studies[1] have found that L-arginine alpha-ketoglutarate increases heart rate, helps lower blood pressure, and increases blood flow. 

Additionally, this product has positive reviews, and the company offers free fast shipping. If you are not satisfied, you have a sixty-day money-back guarantee.

Transparent Labs BULK

Transparent Labs BULK Pre-Workout

Total Nitric Oxide is designed to support your body’s natural nitric oxide production. Its main goal is to promote workout performance to help with fast recovery and muscle growth.

  • Affordable
  • Stimulant free
  • Helps build muscle and fight fatigue
  • Proprietary blends make it hard to know exact ingredient benefits

These nitric oxide boosters contain fermented beetroot, oxyphyte grape seed extract, oxyphyte apple extract, acerola cherry extract, L-citrulline DL-malate, arginine nitrate, and Careflow mango fruit powder.  Additionally, it is free from gluten, nuts, and soy. 

However, some studies [5]find that L-arginine does not show a significant increase in nitric oxide levels. In contrast, beetroot juices[6] improve nitric oxide levels, which in turn create more blood flow to muscles. Beetroot juice can also help increase overall workout performance. 

As we mentioned above, L- citrulline is known to help enhance blood flow allowing more muscle pumps. 

This dietary supplement is a powder form. You take one scoop and mix it with at least eight ounces of water up to two times a day. It comes in a harvest fruit flavor with twenty servings.

Huge Nutrition Magnify

Magnify advanced nitric oxide formula is one of the best nitric oxide boosters on the market. It promises to offer the highest dosed pump pills out there with scientifically-backed ingredients.

  • Scientifically-backed ingredients
  • Supplement can be stacked with other products
  • Made in the USA
  • You have to take a whopping five capsules before a workout

This formula includes the following ingredients L-arginine, beetroot extract, L-citrulline, Norvaline (green coffee bean extract, tart cherry, blueberry, broccoli, & kale), Bioperine, and Green Tea Extract. 

In contrast to what some reports claim, L-arginine is an amino acid that plays a big part in nitric oxide production. Consequently, this plays an essential role in regulating the body’s blood pressure and immune system. 

Furthermore, some evidence has shown[7] that L-arginine can help lower blood pressure. Therefore, L- arginine is a fantastic ingredient in this product. 

Additionally, this product has excellent reviews from real customers. Nitric Oxide advanced formula is made in the United States in an FDA-approved facility. 

BlueEarth’s L-Arginine + L-Citrulline

This dietary supplement blend is targeted for cardiovascular health, nitric oxide boosting, and supporting your blood pressure. Boosting nitric oxide levels within the blood vessel wall will help the blood vessels relax and lower blood pressure.

  • Cardio health formula
  • Blood pressure support
  • Affordable
  • Not FDA- approved

The main ingredients within this supplement are obviously L-arginine and L-citrulline. These powerful ingredients are known for producing nitric oxide. It is made in the United States, comes in multiple flavors, and is easy to mix.  

You can also find additional vitamin nutrients within this supplement like vitamin D, vitamin C, and vitamin B12. Furthermore, customers are extremely satisfied with this product giving it a five-star review. 

SNAP Nitric Oxide Organic Beets

Coming up next is the organic beets nitric oxide booster made by SNAP supplements. This supplement aims to support heart muscle function, help with cholesterol levels, support cardiovascular health, and increase energy levels.

  • Supports blood vessels
  • Non-GMO, gluten-free, and vegan
  • 90-day money-back guarantee
  • Includes proprietary blend

Organic beetroot can be found in many nitric oxide boosting supplements. Some of the best nitric oxide supplements on the market contain beetroot. Beetroot helps widen blood vessels, which in turn enhances circulation and blood flow. Therefore, beetroot is a great natural supplement [8]for reducing cardiovascular disease. 

You can find SNAP Nitric Oxide Booster powder supplements in a few different flavors. Just add one scoop to any beverage of choice and stir it up. 

Additionally, some users like to use Organic Beet as a pre-workout, and it does not contain caffeine, so you can avoid unwanted side effects from that.

PUMP SERUM Pre-Workout

This stimulant-free pre-workout formula contains high-quality ingredients that work together to optimize muscle pumps, help with focus, and increase workout performance. 

  • Stackable with other products
  • Stimulant-free pre-workout
  • Helps with focus & endurance
  • Expensive
  • Only available online

In one scoop, you get a variety of excellent ingredients like beetroot extract, pomegranate extract, Bioperine, and Nitrosigine. As we know, beetroot extract is an ideal supplement for increasing nitric oxide. Additionally, some studies[9]have found that pomegranate extract is beneficial for increasing blood flow and expanding blood vessels.

This nitric oxide boosting supplement is popular with men and made in the United States. The company is proud of its ingredients and promises to only manufacture them in a GMP-certified facility that is FDA-approved.  However, this product is expensive and has limited flavor options.

Benefits of Nitric Oxide Supplements

Nitric Oxide supplementation is optimal for those who are working to support muscle growth. Not only is it great for muscle growth, but it is also great for cardiovascular health and controlling blood pressure. 

Believe it or not, nitric oxide supplements can also help with erectile dysfunction. For instance, evidence[10] has found that L-arginine and L-citrulline may help patients with erectile dysfunction.

Potential Side Effects

Although nitric oxide is typically healthy and safe for consumption, too much of anything can cause adverse effects. Some mild side effects may arise, such as diarrhea, stomach discomfort, headaches, and nausea. 

Additionally, it is crucial to check nitric oxide supplements for ingredients that may cause an allergic reaction. We highly recommend reaching out to your professional medical physician before starting any new supplement, especially taking other supplements or medications.  

Furthermore, ensure that you take the recommended dosage listed on the product. Do not exceed the recommended dose to avoid any adverse effects. 

How To Choose The Best Nitric Oxide Boosters

It is important to choose a nitric oxide booster that is right for you. The best nitric oxide supplement will have quality ingredients that are scientifically-backed by evidence. 

You should ensure that the supplement has enough of the ingredient to see results and be effective enough to increase nitric oxide production. 

Final Thought

Overall, boosting nitric oxide production seems beneficial for building muscle growth, enhancing blood vessel health, and improving muscle pumps in the gym. 

We recommend taking a look at the ingredients in the product to see that you are getting the best bang for your buck. Look at customer reviews for potential problems with the product or company or possible side effects not noted elsewhere.

Frequently Asked Questions

Does nitric oxide have to be taken as a supplement, or can you find it in food?

No! Nitric oxide can be found in many food sources, and these foods will increase nitric oxide levels within your body. Some of the most popular are beets, pomegranates, and dark leafy greens, like spinach.

Can I take nitric oxide supplements to help lower my blood pressure? 

Nitric oxide allows the blood vessels to relax, increase blood flow, and lower blood pressure. Therefore, yes, nitric oxide can help lower your blood pressure.

Do nitric oxide supplements cause you to gain weight?

No, taking nitric oxide supplements does not cause you to gain weight. You need to check the supplement before taking it, though, for added sugars or fillers that may cause weight gain.

Should you take nitric oxide supplements if you have high blood pressure?

When taking supplements with prescription medications, you risk the chance of having interactions. So if you have a medical condition, it is vital that you check with a medical professional before starting a nitric oxide supplement.

Do nitric oxide boosting ingredients contain caffeine or other stimulants?

Yes and no. Not all products made to increase nitric oxide are made with caffeine or other added stimulants. There are several supplements on the market that are stimulant-free. This is great news for those sensitive to caffeine who want to avoid it altogether. 


+ 10 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Willoughby, D.S., Boucher, T., Reid, J., Skelton, G. and Clark, M. (2011). Effects of 7 Days of Arginine-Alpha-Ketoglutarate Supplementation on Blood Flow, Plasma L-Arginine, Nitric Oxide Metabolites, and Asymmetric Dimethyl Arginine After Resistance Exercise. International Journal of Sport Nutrition and Exercise Metabolism, [online] 21(4), pp.291–299. Available at: https://pubmed.ncbi.nlm.nih.gov/21813912/
  2. Bloomer, R.J., Farney, T.M., Trepanowski, J.F., McCarthy, C.G. and Canale, R.E. (2011). Effect of betaine supplementation on plasma nitrate/nitrite in exercise-trained men. Journal of the International Society of Sports Nutrition, [online] 8(1). Available at: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3066115/#:~:text=With%20regards%20to%20betaine%20and,nitrite%2C%20a%20surrogate%20marker%20of
  3. Rogers, J.M., Gills, J. and Gray, M. (2020). Acute effects of Nitrosigine® and citrulline malate on vasodilation in young adults. Journal of the International Society of Sports Nutrition, [online] 17(1). Available at: https://pubmed.ncbi.nlm.nih.gov/32093766/
  4. Gonzales, J.U., Raymond, A., Ashley, J. and Kim, Y. (2017). Doesl-citrulline supplementation improve exercise blood flow in older adults? Experimental Physiology, [online] 102(12), pp.1661–1671. Available at: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5999519/
  5. Alvares, T., Conte-Junior, C., Silva, J. and Paschoalin, V.M. (2012). Acute L-Arginine supplementation does not increase nitric oxide production in healthy subjects. Nutrition & Metabolism, [online] 9(1), p.54. Available at: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3489573/
  6. Domínguez, R., Cuenca, E., Maté-Muñoz, J., García-Fernández, P., Serra-Paya, N., Estevan, M., Herreros, P. and Garnacho-Castaño, M. (2017). Effects of Beetroot Juice Supplementation on Cardiorespiratory Endurance in Athletes. A Systematic Review. Nutrients, [online] 9(1), p.43. Available at: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5295087/
  7. McRae, M.P. (2016). Therapeutic Benefits of l-Arginine: An Umbrella Review of Meta-analyses. Journal of Chiropractic Medicine, [online] 15(3), pp.184–189. Available at: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5021928/
  8. The BEETing of your Heart. (2017). [online] Available at: https://www.lehman.edu/dietetic-internship-program/documents/TheBEETing-of-your-Heart-by-Annie-Rusoff.pdf.
  9. Roelofs, E.J., Smith-Ryan, A.E., Trexler, E.T., Hirsch, Katie R. and Mock, M.G. (2016). Effects of pomegranate extract on blood flow and vessel diameter after high-intensity exercise in young, healthy adults. European Journal of Sport Science, [online] 17(3), pp.317–325. Available at: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5563971/
  10. Barassi, A., Corsi Romanelli, M.M., Pezzilli, R., Damele, C.A.L., Vaccalluzzo, L., Goi, G., Papini, N., Colpi, G.M., Massaccesi, L. and Melzi d’Eril, G.V. (2017). Levels of l -arginine and l -citrulline in patients with erectile dysfunction of different etiology. Andrology, [online] 5(2), pp.256–261. Available at: https://pubmed.ncbi.nlm.nih.gov/28178400/‌

Medically reviewed by:

Alycia Watts is a freelance writer with a Bachelor’s degree in Business Administration (BBA). She has a passion for all topics involving lifestyle, health, and nutrition. Her goal is to educate others and share her passion. When she is not reading or writing, she enjoys spending time with family and friends.

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