Fact checkedExpert's opinion

The article is a subjective view on this topic written by writers specializing in medical writing.
It may reflect on a personal journey surrounding struggles with an illness or medical condition, involve product comparisons, diet considerations, or other health-related opinions.

Although the view is entirely that of the writer, it is based on academic experiences and scientific research they have conducted; it is fact-checked by a team of degreed medical experts, and validated by sources attached to the article.

The numbers in parenthesis (1,2,3) will take you to clickable links to related scientific papers.

7 Best Stimulant-Free Fat Burners On The Market 2023

Mitchelle Morgan

Updated on - Written by
Medically reviewed by Dr G. Michael DiLeo, MD

All articles are produced independently. When you click our links for purchasing products, we earn an affiliate commission. Learn more about how we earn revenue by reading our advertise disclaimer.



  • Appetite-suppressant
  • Natural ingredients
  • Female fat burner

Burn Lab Pro

Burn Lab Pro

  • Boosts fat metabolism
  • Preserve muscle mass
  • Releases stored fat reserves

Transparent Labs Fat Burner Stim-Free

Transparent Labs Fat Burner Stim-Free

  • GMO-free
  • Scientifically proven ingredients
  • Contains adaptogens

People on various weight loss journeys experiment with various methods to achieve their ideal weight, and, because fat burning is such an important part of weight loss, using a fat burner supplement could be a good idea.

There are many fat-burning supplements available, but not all of them work for everyone. People who are sensitive to stimulants like caffeine, yohimbine, or theacrine are one group who cannot use all fat burners. As a result, they look for the best non-stimulant fat burners that offer the same effects without containing any stimulants.

This article delves deeply into revealing seven of the best non-stimulant fat burners for weight loss. We’ll go over the benefits, drawbacks, and ingredient list for each product and what the active ingredients do to help you lose weight.

7 Best Stimulant-Free Fat Burners on the market in (September. 2023)

Fat-burners do not necessarily torch up the fat cells and evaporate them. Instead, they work in three main ways to facilitate weight loss:

  1. They boost your metabolism, so you burn more calories.
  2. They reduce the amount of fat that your body absorbs chemically from the intestinal tract.
  3. They suppress your appetite, so you consume less volume and fewer calories.

In the first case, thermogenic fat burners boost metabolism and calorie burning by raising the body’s core temperature. These supplements may not cause significant weight loss[1]. so you must exercise to see a difference.

Second, these fat-burners reduce the amount of fat your body absorbs from the gut, which allows it to pass through your digestive tract undigested or only partially digested.

The glucomannan in some fat-burners aids appetite suppression. A 2022 publication[2] on glucomannan and weight loss had conflicting results. The study’s weakness was that the different results, as compared to previous studies, were due to different types of subjects, depending on the study. 

Previous studies[3] had used only obese subjects, but the previous one used healthy, overweight, or only mildly obese subjects, indicating glucomannan may work differently depending on the nature of the obesity (i.e., obese, mild obesity, or just overweight).

Past studies demonstrated glucomannan’s effectiveness when combined with exercise and diet, so, in retrospect, a healthy diet and exercise could help.

What Are Non-Stimulant Fat Burners?

A non-stim fat-burner supplement contains all the beneficial pre-workout ingredients, such as cayenne pepper extracts and green tea extracts, but none of the caffeine or other stimulants.

Although these stim-free alternatives do not include such stimulants, the user will still experience a significant boost in their metabolism to burn body fat and aid weight loss.

In fact, their ingredients are just as effective in providing significant benefits such as weight loss, improved muscle recovery, reduced muscle soreness, blood pressure regulation, and aerobic fitness.

Please be aware that certain products containing trace quantities of stimulants such as caffeine may be labeled as low-stimulant fat burners. Therefore, they’re not technically “non-stim” but “low-stim”; when utilizing these fat burners, the jittery sensation is frequently absent in spite of the stimulants due to their minimal presence.

Do Stimulant-Free Fat Burners Work?

Yes, stim-free fat burners work because the alternative ingredients have similar or superior effects to stimulants, minus the jitters and crashes of typical stimulants.

For instance, cayenne pepper, in addition to boosting your metabolic activity, is known to help you burn more calories due to its spicy nature. Peppers mimic heat in the body by stimulating the same temperature receptors, yet, the body reacts the same. (The cause is different, but the effect is the same). When you consume spicy food, your core body temperature goes up.

When your body temperature rises[4], your body will burn calories until it enters a cooling-down mode. There is a significant increase in activity against brown fat, associated with the resulting weight loss.

Brown fat-burning produces heat without causing shivering, a process called thermogenesis. As the brown fat burns, it counteracts the calories ingested that had caused the brown fat.

So, stimulant-free fat burners work if they have the right ingredients that offer the body the optimum conditions to burn fat.

7 Best Non-Stimulant Fat Burners On The Market 2023


Leanbean is a fat burner and food-craving suppressant. The product is made by the Ultimate Life Ltd. company, which also produces other health supplements for weight loss.

  • Easy to order
  • This non-stim fat burner is made with natural ingredients
  • Leanbean aids in the reduction of sugar cravings
  • You can burn more calories
  • For some people, this non-stim fat burner takes a long time to work
  • Some ingredients have studies that aren’t conclusive
  • It is only available for purchase on the official website

Leanbean’s effectiveness is boosted by the company’s claim that they are the best non-stim fat-burner and use only natural ingredients. So here is everything it contains:

Leanbean’s all-natural ingredients include acai berry. The manufacturer picked berries because they are nutrient-dense and help the body recover after weight loss. These berries are full of antioxidants[5] that neutralize free radicals. Some research[6] suggests acai berry can also improve cholesterol levels.

Vitamins B6 and B12[7] help maintain a healthy weight. They can also boost the metabolism for endurance activities. Optimal vitamin concentrations offer relief for fatigue, keeping you healthy and fit. These two nutrients support muscle mass function after losing weight.

Although the liver makes choline naturally, you may need to supplement for more benefits. Naturally or via a supplement, choline removes cholesterol and fats from the body. Choline boosts fat metabolism[8], and weight loss results from a more robust fat loss.

Leanbean fat burner contains chromium picolinate[9] which helps to regulate blood sugar. This fat burner helps the body lose weight by reducing insulin spikes.

Garcinia cambogia is often in female fat-burners and weight loss products since it aids in both. It suppresses hunger[10] and burns fat. Garcinia cambogia boosts brain serotonin[11], an appetite suppressant that reduces depression and anxiety symptoms. Studies regarding this ingredient need more backing since the results of multiple studies are contradictory.

Green coffee bean extract contains chlorogenic acid and antioxidants, useful in weight loss[12] and nutritional supplements. Green coffee contains small quantities of natural caffeine, making it a mild stimulant; nevertheless, it still may provoke the same caffeine-like side effects[13]

For example, the chlorogenic acid it[14] contains may cause diarrhea in some individuals. Some people are even hypersensitive to green coffee beans since it has been proven to be an allergen in some.

Like other fat burners, Glucomannan helps you feel satisfied longer[15] and aids digestion. The Glucomannan fiber in this stimulant-free burner boosts healthy energy levels on a restricted diet.

Piperine[16] is a black pepper extract that adds flavor and enhances the bioavailability of fat burners. Piperine helps your body digest more essential vitamins and minerals. It may improve the effectiveness of other Leanbean ingredients.

Potassium Chloride is a potent electrolyte that helps with weight loss by hydrating the body. As a salt that attracts water to the body, it keeps the body hydrated, while other natural ingredients monitor and control blood sugar or burn belly fat for weight reduction. It also helps the stomach cells generate hydrochloric acid, among other electrolytes, which promotes normal digestion.

Turmeric[17] is a thermogenic nutrient that decreases BMI, weight, and leptin. It’s been a spice for centuries, used in the place of Caffeine anhydrous, a common ingredient in male fat burners. Curcumin, the active antioxidant in turmeric, like all antioxidants, has many health benefits.

Zinc reduces inflammation[18] and boosts immunity. This mineral facilitates carbohydrate and fat metabolism[19]. The same benefits apply to protein synthesis for healthy muscles, particularly after fat loss.

Burn Lab Pro

Burn Lab Pro contains a unique combination of ingredients that selectively burns fat while preserving all of your muscle mass. For that reason, it’s beloved by men in bodybuilding and weight lifting in addition to those on a weight loss journey.

  • It’s vegan-friendly
  • It has a high fat-burning capacity while maintaining muscle mass strength
  • It contains clinically-tested ingredients
  • Clients receive discounts from the company
  • It contains no vitamins
  • It is expensive when compared to other stim-free fat burners on the market
  • You can only purchase this stim-free supplement online from the brand’s official website

The fact that Burn Lab Pro uses a dual thermogenic blend to boost your metabolic activity, while also initiating enhanced fat oxidation in brown adipose tissue, makes it a truly unique blend and one of the best fat burners.

The complete ingredient list is

  • Coleus Forskohlii Root- an Ayurvedic herb
  • Piperine- black pepper extract
  • GTF Chromium
  • Calcium
  • Capsimax-chilli pepper extract
  • Hydroxymethylbutyrate (HMB)

HMB[20] is one of the final products in the metabolism of leucine, a branched-chain amino acid that aids in protein absorption by muscle fibers. Capsimax is a proprietary blend of piperine and capsicum that aids weight loss by increasing your body’s natural thermogenesis.

GTF Chromium, calcium, and Coleus forskohlii root aid in releasing fat reserves. Calcium may also increase fat oxidation[21].

One of its most important strategies for losing weight quickly is in releasing your body’s fat stores.

Its ingredients aid in the breakdown of body fat, which is stored energy, releasing it into the bloodstream to be utilized by other cells. This boost in energy will enable you to lift heavier loads for more reps, improving your endurance over time.

Transparent Labs Fat Burner Stim-Free

Transparent Lab is a brand that has been in the market for decades and which has always ensured its clients they offer only the best products. This stim-free has the added advantage of having an adaptogen that aids weight loss via counteracting stress.

  • Labels that are always transparent with all information needed
  • For what you get, the price is reasonable
  • There are no harmful additives or fillers in this product
  • It consists of adaptogens that hedge against stress
  • It is vegan-friendly
  • Some ingredients included in the mix have conflicting data in the scientific literature

B12 is needed for energy, nerve health, DNA synthesis, red blood cell formation, and cellular metabolism.

Acetyl-L-carnitine is used in weight-loss supplements and may boost cognitive performance. The fatty acids it transports to the mitochondria allow the body to combust fatty acids for fuel. As for weight loss, studies are mixed, with some revealing no benefits. A 2016 review[22] found that L-carnitine users lost more weight than control groups.

Forskolin is a promising fat-loss ingredient, but human studies are rare compared to animal studies. It may reduce[23] body fat mass and body fat percentage.

5-HTP may quash appetite by increasing brain serotonin. Serotonin regulates our feelings, sleep, feeding, and digestion. It suppresses hunger hormones to increase fullness[24]. In a study[25] of 20 people with diabetes and obese people who gave 5-HTP or a placebo, the first group ate fewer calories and lost weight.

Rhodiola Rosea is an adaptogenic compound that helps the body manage bodily and psychological stress[26]. In one animal study[27], Rhodiola Rosea and citrus Aurantium were found to reduce insulin-resistant fat cells.

Cayenne has fat-burning and low appetite-inducing effects. Diet-induced thermogenesis raises body temperature and burns more calories. Its impacts on appetite[28] play a part more in fat loss since foods alone don’t increase metabolism enough to create significant calorie-burning.

Fucoxanthin isn’t well-studied, so you may not have heard of it. Fucoxanthin is a carotenoid found in some edible seaweeds. It has both anti-obesity and thermogenic properties that promote fat loss. A 16-day treatment[29] with 300mg pomegranate seed oil, 300mg brown seaweed extract, and 2.4mg fucoxanthin reduced women’s fat mass and liver fat. Fucoxanthin prevents and treats lifestyle-related diseases like obesity, cancer, and diabetes.

Jacked Factory Lean XT

Lean-XT is a women’s and men’s thermogenic stim-free weight loss supplement. It’s manufactured with all-natural ingredients and promoted as a caffeine-free, stim-free fat burner that helps preserve lean muscle during the otherwise destructive process of fat-burning.

  • Affordable
  • Lacks artificial colors, dyes, and fillers
  • It is manufactured in a CGMP facility
  • It supports the suppression of appetite
  • It provides a significant energy boost all through workouts
  • Customer service is excellent at this company
  • Fat-burner that is vegetarian-friendly and non-stimulant
  • While taking this fat burner, some users mentioned putting on weight
  • It may make you feel bloated
  • It may affect your bowel movements

The Lean-XT marketed by Jacked Factory is a stim-free fat burner that uses all-natural ingredients to facilitate weight loss.

It accomplishes this in two distinct ways. First, it reduces your daily calorie consumption by suppressing your appetite. Second, it increases your metabolism, allowing your body to burn more calories daily.

It contains the following ingredients:

  • Lean-primary XT’s fat-burning ingredient is Acetyl L-Carnitine[30]. This ingredient carries fatty acids into the mitochondria, which combusts them for energy. Acetyl L-carnitine helps memory, thinking, and neuropathic pain.
  • Bioperine has many benefits, but it’s renowned for boosting nutrient absorption. Bioperine boosts metabolism by increasing thermogenesis.
  • Forskolin reduces body fat percentage and fat mass in a clinical study[23] on obese men. Researchers also saw an increase in testosterone, which promotes muscle growth.
  • Green tea extract contains catechins, which are antioxidants. Epigallocatechin gallate is the healthiest green tea catechin, and it aids in weight loss and fat oxidation, especially when combined with caffeine[31]. When taken alone, however, these effects aren’t consistent—green tea extract functions as a mild stimulant to boost concentration and mental clarity in caffeine-free Lean XT.

Jacked Factory Lean PM

One of the downsides of stimulant fat burners is that they disrupt your sleeping patterns, but stim-free fat burners may reverse them. With Jacked Factory Lean PM, you get sleep quality and weight loss support.

  • Works for both fat loss and better sleep patterns
  • The product is manufactured in a cGMP facility
  • It is safe and easy to use
  • Compared to other products, it lacks some key ingredients

Lean PM promotes its organic ingredients with scientifically supported assertions about just how much restful sleep can facilitate fat loss. It contains ingredients that promote quality sleep and aid fat burning in the body that is at rest.

Black Pepper Extract boosts the blend’s synergistic action.

Green Tea Extract has thermogenic effects and weight loss benefits. It is also antioxidant-rich for overall health.

L-Theanine[32] promotes tranquillity and relieves stress, leading to better sleep.

Melatonin[33] is a hormone the body produces that signals sleep and regulates rest. Melatonin multivitamins can enhance your ability to drift off to sleep and the quality of your slumber, which is why it’s included in so many sleeping aids.

Vitamin B6[34] helps with clarity of mind and mood since a B6 deficiency causes depression. B6 may also aid weight reduction by reducing water retention and metabolizing fat.

Lean PM contains magnesium[35] to boost restful sleep since a deficiency may cause a disrupted sleeping pattern. 5-Hydroxytryptophan[36], or 5-HTP, improves mood, rest, mental alertness, and appetite by regulating serotonin yield in the central nervous system. It appears to fit Lean PMs of soothing, restorative ingredients and appetite suppression, and it helps with weight loss.

Transparent Labs: Stim-Free Free Pre-Workout

The vegan stim-free fat-burning supplement franchise is well-known worldwide. Transparent Labs is straightforward about its ingredients, doses, and substantiated research on why they use a particular ingredient.

  • Its ingredients have been clinically tested
  • It’s much safer than the illegal ephedrine
  • It’s free of GMOs, gluten, and artificial ingredients
  • It is a proprietary combination
  • It is vegan-friendly

  • Transparent Lab is a costly fat-burning supplement

Overall, the ingredients in this vegan stimulant-free fat-burning supplement are as follows: 

  • According to a study published in Obesity Research & Clinical Practice[23], ForsLean forskolin administration reduced fat and enhanced lean muscle mass in obese men compared to placebo.
  • As per a study published in the Journal of Nutrition[37], EGCG, and green tea reduce fat biosynthesis, improve sugar usage, and boost fat breakdown.
  • L-tyrosine, also recognized as the bioactive variant of tyrosine, is a potent anti-stress amino acid with multiple functions in the body. As such, its bodyweight-loss advantages come from reducing tiredness[38] (i.e., maintaining metabolism) after intense exercise.
  • 5-HTP is a Griffonia simplicifolia constituent demonstrated to reduce hunger[39] in overweight dieters.
  • Additional ingredients in this fat-burner include cayenne pepper extract, L-theanine, sallicine bark extract, and synephrine HCL.

Cira Shine Stim-Free Fat Burner

Cira Nutrition Shine is a fantastic stim-free fat burner that can help all female users improve their health and athletic performance. It can increase energy levels, enhance healthy metabolic activity, and aid fat loss without stimulants.

  • Excellent ingredients and potent formula
  • Energy levels, fat loss, and healthy metabolism are all aided by this supplement
  • Cira Nutrition is a reputable and trustworthy company
  • Only available through their website

This unique formula contains seven powerful and efficient components that supply all of the perks that the best stimulant-free fat burners can provide. Cira Nutrition addresses the challenges of women’s nutrition as deficiencies, hence the importance of having a good supplement. The product is an excellent example of a top-rated stim-free supplement.

The following are the seven ingredients:

  • Acetyl-L-carnitine is a fat-metabolizing amino acid that can help you lose weight and achieve your desired body composition transformation.
  • Dandelion Root Extract[40] is a coffee alternative that can help you shed water weight, reduce fat permeability, and possibly encourage fat breakdown.
  • EGCG[41] (Epigallocatechin gallate) boosts calorie burn and enables the body to burn body fat for energy. It may also help with appetite suppression, resulting in less binge eating.
  • Coleus forskohlii extract aids weight loss by stimulating the breakdown of stored fat within fat (adipose) cells.
  • Grains of Paradise[42] can help you lose fat, allowing you to achieve the desired results.
  • Capsimax cayenne pepper fruit extract tends to help you lose weight by speeding up your metabolic rate, curbing your appetite, and burning more calories.
  • Bioperine black pepper fruit extract promotes fat loss and achieves the desired result by stimulating the breakdown of fatty cells.
  • Other Ingredients: Magnesium stearate, rice flour, silica, and plant cellulose capsule

What Types of Stimulants Should You Avoid?

Despite some efficacy benefits of stimulants in weight loss, some have unreversible effects with long-term use that poses more harm than good.

So here are some of the stimulants used in some fat-burning supplements that you should avoid:


A research project looked at how caffeine affects body weight regulation by enhancing energy expenditure[43], which means you burn more calories through enhanced fat loss and thermogenesis.

Caffeine has been shown in some studies to cause weight loss in individuals[44].

However, caffeine can cause insomnia, anxiety, jitteriness, nausea, vomiting, irritability, diarrhea, or other symptoms in some individuals. Caffeine is also addictive[45] and can interfere with sleep patterns.

There’s no need to take a caffeine-containing supplement or pill. Green tea extracts in a stimulant-free fat burner are great sources of antioxidants and have other medical benefits that you might otherwise get from caffeine.

High Quantities of Green Coffee Bean Extract

Coffee beans that have not yet been roasted are known as green coffee beans. Chlorogenic acid and caffeine are two active substances that may aid weight loss found in these beans.

As explained above, caffeine boosts fat burning, but chlorogenic acid slows carbohydrate digestion in the digestive tract. In several human studies[46], green coffee bean extract has been shown to help dieters lose weight.

According to a meta-analysis of all existing randomized controlled clinical trials of 2012 on the supplement’s impact on obesity, it has a substantial impact on lowering body mass index[47].

The ingredient has been shown to help lower blood sugar and blood pressure. It also contains a lot of antioxidants. But its downsides are quite similar to caffeine’s side effects of jitters and sometimes headaches and migraines. Also, some studies have indicated it could be an allergen affecting someone similarly who is allergic to caffeine.

In small doses, it may be okay but avoid a fat-burner with high quantities per dose.

Other stimulants that contain caffeine that you should avoid are

How To Choose The Best Non-Stim Fat Burner?

Weight loss supplements, including non-stimulant fat burners, come in various forms and ingredient profiles, so what are the most critical factors to look out for?

Here is a breakdown of the elements you need to consider to get the best non-stimulant fat burners:

Consider the Ingredient List

The foremost factor to consider is whether the non-stimulant fat burner has fat-burning ingredients that work. It would be best to do a bit of research on each ingredient to ascertain whether or not they have any stimulant content and, if so, whether it’s “trace” only. 

They should support healthy energy levels, reduce body fat percentage, and support healthy body composition. The ingredients should also increase fat metabolism (lipolysis) to aid in fat loss.

If they have additional ingredients that promote lean muscle mass, well and good.

However, you should research how they interact with each other to avoid any canceling effects, as is seen with iron when taken with green tea extracts. Iron decreases the efficacy of green tea since it binds with it, making it lose its antioxidant potency[50]. Green tea also affects iron absorption[51], which may lead to anemia. So stay clear from any fat burner supplement with both.

Also, always go for GMO-free, gluten-free, and allergen-free natural ingredients as they have the least side effects.

Consider the Company’s Reputation

When it comes to the manufacturers of fat burners, you can be certain they will use the most enticing and compelling language to convince you they are the best non-stimulant fat-burning supplement. So, should you believe them all?

Certainly not!

Marketing is seduction, and seduction is very fuzzy when it comes to where the lines of integrity are drawn. Keep in mind, that they are drawn by the ones who want to sell you their products. What you need to do is check the brand’s reputation online. Read medical reviews, peruse through the scientifically verified ingredient composition, and scrutinize the customer feedback. Also, check if the company has any FDA warning letters or past or pending lawsuits.

Another significant factor under company reputation is the certifications they hold. Since all dietary supplements are not FDA-approved and regulated, certain extras help validate the legitimacy of a company. These certifications indicate if the product is

  • Free from banned substances: NSF sport.
  • Quality controlled, and the label is verified: The certificate is NSF CGMP, National Science Foundation certified Good Manufacturing Processes. Also, USP[52] verified.
  • GMP (Good Manufacturing Practices) compliant: GMP certified.
  • Gluten-free, kosher[53], vegan, allergen, and GMO-free[54].

If the positive results significantly trump the negative fat-burning considerations, then that is the stim-free burner you should go for. If it’s a close call, steer clear.

Consider the Value for your Money

Even while taking the best stim-free fat burner to support weight loss, ask yourself one question: ‘Can I sustain the financial burden of using non-stimulant fat burners long term?’

You have to realize that even while using the best fat burners, the duration will, in most cases, go beyond a month or two. Always calculate the investment value of the best stim-fat burners you are considering based on a 6- to 12-month duration. Factor in that you may switch your preference to other fat burners if the first or second one does not work for you, which can be a problem if it’s a subscription purchase.

Also, since weight loss is a major adjustment to your physiology, especially by manipulating that physiology with fat burners and possibly even stimulants (“trace” or otherwise), you should consult with your healthcare provider. This will incorporate how safe your plan will be for you and for how long.

Final Thought

After reading this article, deciding on the best non-stimulant fat burner should be simple. You now have a set of criteria to use to determine which option is ideal for you to begin with, along with a few other selections.

Remember that these don’t meal replacement plans but rather dietary supplements. They are only part of a strategy. You must still eat well and exercise for them to be successful.

Most importantly, consult your doctor if you have any allergies or other concerns. They have the last word on whether or not you should utilize non-stim fat burners.

Frequently Asked Questions

What is the best fat burner on the market right now?

The best fat burner on the market at the moment is Leanbeans. This supplement contains science-backed ingredients that have been proven to boost metabolism and aid fat loss. Nonetheless, it may not work for everyone, so you have six other brands to consider.

Do all fat-burner supplements contain caffeine?

Not all fat-burner supplements contain caffeine. Besides the seven we have covered in this piece, other stimulant-free options are available on the market.

What are the potential effects of fat-burner supplements?

The two most common effects of fat burners are behavioral changes and stomach upset issues.

When should I take fat burners?

You should take fat burners when you want to lose fat minus the effects of stimulants like caffeine. But you should use them in conjunction with exercise and a healthy diet. Otherwise, they may not work.

Do non-stimulant fat burners work?

Yes, they do as long as you get the best non-stim fat burner ideal for your body and use it correctly besides a healthy eating plan and exercise.

+ 54 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Clark, J. E., & Welch, S. (2021). Comparing the effectiveness of fat burners and thermogenic supplements to diet and exercise for weight loss and cardiometabolic health: Systematic review and meta-analysis. Nutrition and health, 27(4), 445–459. https://doi.org/10.1177/0260106020982362
  2. Keithley, J. K., Swanson, B., Mikolaitis, S. L., DeMeo, M., Zeller, J. M., Fogg, L., & Adamji, J. (2013). Safety and efficacy of glucomannan for weight loss in overweight and moderately obese adults. Journal of obesity, 2013, 610908. https://doi.org/10.1155/2013/610908
  3. Walsh, D. E., Yaghoubian, V., & Behforooz, A. (1984). Effect of glucomannan on obese patients: a clinical study. International journal of obesity, 8(4), 289–293.
  4. Yoneshiro, T., Aita, S., Matsushita, M., Kayahara, T., Kameya, T., Kawai, Y., Iwanaga, T., & Saito, M. (2013). Recruited brown adipose tissue as an antiobesity agent in humans. The Journal of clinical investigation, 123(8), 3404–3408. https://doi.org/10.1172/JCI67803
  5. NCCIH, (2020). Acai. Available at: https://www.nccih.nih.gov/health/acai.
  6. de Souza, M. O., Silva, M., Silva, M. E., Oliveira, R., & Pedrosa, M. L. (2010). Diet supplementation with acai (Euterpe oleracea Mart.) pulp improves biomarkers of oxidative stress and the serum lipid profile in rats. Nutrition (Burbank, Los Angeles County, Calif.), 26(7-8), 804–810. https://doi.org/10.1016/j.nut.2009.09.007
  7. Harvard T.H.Chan. (2012). B Vitamins. Available at: https://www.hsph.harvard.edu/nutritionsource/vitamins/vitamin-b/.
  8. Zhu, J., Wu, Y., Tang, Q., Leng, Y., & Cai, W. (2014). The effects of choline on hepatic lipid metabolism, mitochondrial function and antioxidative status in human hepatic C3A cells exposed to excessive energy substrates. Nutrients, 6(7), 2552–2571. https://doi.org/10.3390/nu6072552
  9. Yazaki, Y., Faridi, Z., Ma, Y., Ali, A., Northrup, V., Njike, V. Y., Liberti, L., & Katz, D. L. (2010). A pilot study of chromium picolinate for weight loss. Journal of alternative and complementary medicine (New York, N.Y.), 16(3), 291–299. https://doi.org/10.1089/acm.2009.0286
  10. Westerterp-Plantenga, M. S., & Kovacs, E. M. (2002). The effect of (-)-hydroxycitrate on energy intake and satiety in overweight humans. International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity, 26(6), 870–872. https://doi.org/10.1038/sj.ijo.0801979
  11. Feijó, F., Bertoluci, M. C., & Reis, C. (2011). Serotonina e controle hipotalâmico da fome: uma revisão [Serotonin and hypothalamic control of hunger: a review]. Revista da Associacao Medica Brasileira (1992), 57(1), 74–77.
  12. Haidari, F., Samadi, M., Mohammadshahi, M., Jalali, M.T., Engali, K.A. (2017). Energy restriction combined with green coffee bean extract affects serum adipocytokines and the body
    composition in obese women. Available at: https://apjcn.nhri.org.tw/server/APJCN/26/6/1048.pdf
  13. Willson C. (2018). The clinical toxicology of caffeine: A review and case study. Toxicology reports, 5, 1140–1152. https://doi.org/10.1016/j.toxrep.2018.11.002
  14. Manavski, N., Peters, U., Brettschneider, R., Oldenburg, M., Baur, X., & Bittner, C. (2012). Cof a 1: identification, expression and immunoreactivity of the first coffee allergen. International archives of allergy and immunology, 159(3), 235–242. https://doi.org/10.1159/000337461
  15. Howarth, N. C., Saltzman, E., & Roberts, S. B. (2001). Dietary fiber and weight regulation. Nutrition reviews, 59(5), 129–139. https://doi.org/10.1111/j.1753-4887.2001.tb07001.x
  16. Shah, S. S., Shah, G. B., Singh, S. D., Gohil, P. V., Chauhan, K., Shah, K. A., & Chorawala, M. (2011). Effect of piperine in the regulation of obesity-induced dyslipidemia in high-fat diet rats. Indian journal of pharmacology, 43(3), 296–299. https://doi.org/10.4103/0253-7613.81516
  17. Akbari, M., Lankarani, K. B., Tabrizi, R., Ghayour-Mobarhan, M., Peymani, P., Ferns, G., Ghaderi, A., & Asemi, Z. (2019). The Effects of Curcumin on Weight Loss Among Patients With Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Frontiers in pharmacology, 10, 649. https://doi.org/10.3389/fphar.2019.00649
  18. Prasad A. S. (2014). Zinc is an Antioxidant and Anti-Inflammatory Agent: Its Role in Human Health. Frontiers in nutrition, 1, 14. https://doi.org/10.3389/fnut.2014.00014
  19. Olechnowicz, J., Tinkov, A., Skalny, A., & Suliburska, J. (2018). Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism. The journal of physiological sciences: JPS, 68(1), 19–31. https://doi.org/10.1007/s12576-017-0571-7
  20. Engelen, M., & Deutz, N. (2018). Is β-hydroxy β-methyl butyrate an effective anabolic agent to improve outcomes in older diseased populations?. Current opinion in clinical nutrition and metabolic care, 21(3), 207–213. https://doi.org/10.1097/MCO.0000000000000459
  21. Gonzalez, J. T., Rumbold, P. L., & Stevenson, E. J. (2012). Effect of calcium intake on fat oxidation in adults: a meta-analysis of randomized, controlled trials. Obesity reviews : an official journal of the International Association for the Study of Obesity, 13(10), 848–857. https://doi.org/10.1111/j.1467-789X.2012.01013.x
  22. Pooyandjoo, M., Nouhi, M., Shab-Bidar, S., Djafarian, K., & Olyaeemanesh, A. (2016). The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obesity reviews: an official journal of the International Association for the Study of Obesity, 17(10), 970–976. https://doi.org/10.1111/obr.12436
  23. Godard, M. P., Johnson, B. A., & Richmond, S. R. (2005). Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obesity Research, 13(8), 1335–1343. https://doi.org/10.1038/oby.2005.162
  24. Heisler, L. K., Jobst, E. E., Sutton, G. M., Zhou, L., Borok, E., Thornton-Jones, Z., Liu, H. Y., Zigman, J. M., Balthasar, N., Kishi, T., Lee, C. E., Aschkenasi, C. J., Zhang, C. Y., Yu, J., Boss, O., Mountjoy, K. G., Clifton, P. G., Lowell, B. B., Friedman, J. M., Horvath, T., … Cowley, M. A. (2006). Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron, 51(2), 239–249. https://doi.org/10.1016/j.neuron.2006.06.004
  25. Cangiano, C., Laviano, A., Del Ben, M., Preziosa, I., Angelico, F., Cascino, A., & Rossi-Fanelli, F. (1998). Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin-dependent diabetic patients. International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity, 22(7), 648–654. https://doi.org/10.1038/sj.ijo.0800642
  26. Li, Y., Pham, V., Bui, M., Song, L., Wu, C., Walia, A., Uchio, E., Smith-Liu, F., & Zi, X. (2017). Rhodiola Rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention. Current pharmacology reports, 3(6), 384–395. https://doi.org/10.1007/s40495-017-0106-1
  27. Verpeut, J. L., Walters, A. L., & Bello, N. T. (2013). Citrus aurantium and Rhodiola Rosea in combination reduce visceral white adipose tissue and increase hypothalamic norepinephrine in a rat model of diet-induced obesity. Nutrition research (New York, N.Y.), 33(6), 503–512. https://doi.org/10.1016/j.nutres.2013.04.001
  28. Smeets, A. J., & Westerterp-Plantenga, M. S. (2009). The acute effects of a lunch containing capsaicin on energy and substrate utilisation, hormones, and satiety. European journal of nutrition, 48(4), 229–234. https://doi.org/10.1007/s00394-009-0006-1
  29. Zhang, H., Tang, Y., Zhang, Y., Zhang, S., Qu, J., Wang, X., Kong, R., Han, C., & Liu, Z. (2015). Fucoxanthin: A Promising Medicinal and Nutritional Ingredient. Evidence-based complementary and alternative medicine : eCAM, 2015, 723515. https://doi.org/10.1155/2015/723515
  30. Talenezhad, N., Mohammadi, M., Ramezani-Jolfaie, N., Mozaffari-Khosravi, H., & Salehi-Abargouei, A. (2020). Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis of 37 randomized controlled clinical trials with dose-response analysis. Clinical Nutrition ESPEN, 37, 9–23. https://doi.org/10.1016/j.clnesp.2020.03.008
  31. Vázquez Cisneros, L. C., López-Uriarte, P., López-Espinoza, A., Navarro Meza, M., Espinoza-Gallardo, A. C., & Guzmán Aburto, M. B. (2017). Efectos del té verde y su contenido de galato de epigalocatequina (EGCG) sobre el peso corporal y la masa grasa en humanos. Una revisión sistemática [Effects of green tea and its epigallocatechin (EGCG) content on body weight and fat mass in humans: a systematic review]. Nutricion hospitalaria, 34(3), 731–737. https://doi.org/10.20960/nh.753
  32. Kim, S., Jo, K., Hong, K. B., Han, S. H., & Suh, H. J. (2019). GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharmaceutical biology, 57(1), 65–73. https://doi.org/10.1080/13880209.2018.1557698
  33. Zisapel, N. (2009). Melatonin and Sleep. Available at: https://www.researchgate.net/publication/268424605_Melatonin_and_Sleep
  34. Kennedy D. O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy–A Review. Nutrients, 8(2), 68. https://doi.org/10.3390/nu8020068
  35. Djokic, G., Vojvodić, P., Korcok, D., Agic, A., Rankovic, A., Djordjevic, V., Vojvodic, A., Vlaskovic-Jovicevic, T., Peric-Hajzler, Z., Matovic, D., Vojvodic, J., Sijan, G., Wollina, U., Tirant, M., Thuong, N. V., Fioranelli, M., & Lotti, T. (2019). The Effects of Magnesium – Melatonin – Vit B Complex Supplementation in Treatment of Insomnia. Open access Macedonian journal of medical sciences, 7(18), 3101–3105. https://doi.org/10.3889/oamjms.2019.771
  36. Maffei M. E. (2020). 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. International journal of molecular sciences, 22(1), 181. https://doi.org/10.3390/ijms22010181
  37. Grove, K. A., & Lambert, J. D. (2010). Laboratory, epidemiological, and human intervention studies show that tea (Camellia sinensis) may be useful in the prevention of obesity. The Journal of nutrition, 140(3), 446–453. https://doi.org/10.3945/jn.109.115972
  38. ter Borg, P. C., Fekkes, D., Vrolijk, J. M., & van Buuren, H. R. (2005). The relation between plasma tyrosine concentration and fatigue in primary biliary cirrhosis and primary sclerosing cholangitis. BMC gastroenterology, 5, 11. https://doi.org/10.1186/1471-230X-5-11
  39. Clinical Trials. (2006). The Effect of 5-Hydroxytryptophan (5-HTP) on Satiety. Available at: https://clinicaltrials.gov/ct2/show/study/NCT00328913.
  40. NCCIH, (2020). Dandelion. Available at: https://www.nccih.nih.gov/health/dandelion
  41. Hodgson, A. B., Randell, R. K., & Jeukendrup, A. E. (2013). The effect of green tea extract on fat oxidation at rest and during exercise: evidence of efficacy and proposed mechanisms. Advances in nutrition (Bethesda, Md.), 4(2), 129–140. https://doi.org/10.3945/an.112.003269
  42. Sugita, J., Yoneshiro, T., Sugishima, Y., Ikemoto, T., Uchiwa, H., Suzuki, I., & Saito, M. (2014). Daily ingestion of grains of paradise (Aframomum melegueta) extract increases whole-body energy expenditure and decreases visceral fat in humans. Journal of nutritional science and vitaminology, 60(1), 22–27. https://doi.org/10.3177/jnsv.60.22
  43. Harpaz, E., Tamir, S., Weinstein, A., & Weinstein, Y. (2017). The effect of caffeine on energy balance. Journal of basic and clinical physiology and pharmacology, 28(1), 1–10. https://doi.org/10.1515/jbcpp-2016-0090
  44. Yoshida, T., Sakane, N., Umekawa, T., & Kondo, M. (1994). Relationship between basal metabolic rate, thermogenic response to caffeine, and body weight loss following combined low calorie and exercise treatment in obese women. International journal of obesity and related metabolic disorders: journal of the International Association for the Study of Obesity, 18(5), 345–350.
  45. Jain, S., Srivastava, A., Verma, R., & Maggu, G. (2019). Caffeine addiction: Need for awareness and research and regulatory measures. Asian Journal Of Psychiatry, 41, 73-75. DOI: 10.1016/j.ajp.2017.01.008
  46. Sudeep, H. V., & Shyam Prasad, K. (2021). Supplementation of green coffee bean extract in healthy overweight subjects increases lean mass/fat mass ratio: A randomized, double-blind clinical study. SAGE open medicine, 9, 20503121211002590. https://doi.org/10.1177/20503121211002590
  47. Manavski, N., Peters, U., Brettschneider, R., Oldenburg, M., Baur, X., & Bittner, C. (2012). Cof a 1: identification, expression, and immunoreactivity of the first coffee allergen. International archives of allergy and immunology, 159(3), 235–242. https://doi.org/10.1159/000337461
  48. Bortolin, R. C., Vargas, A. R., de Miranda Ramos, V., Gasparotto, J., Chaves, P. R., Schnorr, C. E., da Boit Martinello, K., Silveira, A. K., Gomes, H. M., Rabelo, T. K., Grunwald, M. S., Ligabue-Braun, R., Gelain, D. P., & Moreira, J. (2019). Guarana supplementation attenuated obesity, insulin resistance, and adipokines dysregulation induced by a standardized human Western diet via brown adipose tissue activation. Phytotherapy research: PTR, 33(5), 1394–1403. https://doi.org/10.1002/ptr.6330
  49. Paik, D. J., & Lee, C. H. (2015). Review of cases of patient risk associated with ginseng abuse and misuse. Journal of ginseng research, 39(2), 89–93. https://doi.org/10.1016/j.jgr.2014.11.005
  50. Marjorie S. Miller. (2016). Green tea and iron, bad combination. Available at: https://www.psu.edu/news/research/story/green-tea-and-iron-bad-combination/#:~:text=%22If%20you%20drink%20green%20tea,its%20potential%20as%20an%20antioxidant.
  51. Fan F. S. (2016). Iron deficiency anemia due to excessive green tea drinking. Clinical case reports, 4(11), 1053–1056. https://doi.org/10.1002/ccr3.707
  52. USP. (n.d). USP Verified Mark. Available at: https://www.usp.org/verification-services/verified-mark.
  53. OuKosher. (n.d). What Does Kosher Certified Mean?. Available at: https://oukosher.org/what-is-kosher/.
  54. The Non-GMO Project – Everyone Deserves an Informed Choice. (2016). Verification FAQs – The Non-GMO Project. [online] Available at: https://www.nongmoproject.org/product-verification/verification-faqs/
Mitchelle Morgan

Medically reviewed by:

Michael DiLeo

Mitchelle Morgan is a health and wellness writer with over 10 years of experience. She holds a Master's in Communication. Her mission is to provide readers with information that helps them live a better lifestyle. All her work is backed by scientific evidence to ensure readers get valuable and actionable content.

Medically reviewed by:

Michael DiLeo

Journal of Physical Education and Sport

Trusted Source

Go to source

SciELO - Scientific Electronic Library Online

Trusted Source

Go to source

African Journals Online

Non-profit Platform for African Journals

Trusted Source
Go to source

Journal of The American Board of Family Medicine

American Board of Family Medicine

Trusted Source
Go to source


RMIT University Library

Trusted Source
Go to source

European Food Safety Authority

Science, Safe food, Sustainability

Trusted Source
Go to source


American Academy of Orthopaedic Surgeons

Trusted Source
Go to source

American Academy of Family Physicians

Strengthen family physicians and the communities they care for

Trusted Source
Go to source

Agricultural Research Service

U.S. Department of Agriculture

Trusted Source
Go to source

The American Journal of Medicine

Official Journal of The Alliance for Academic Internal Medicine

Trusted Source
Go to source

National Institute on Alcohol Abuse and Alcoholism

Database From National Institute Of Health

Trusted Source
Go to source

Lippincott Journals

Subsidiaries of Wolters Kluwer Health, Inc.

Trusted Source
Go to source

National Institute on Aging

Database From National Institute Of Health

Trusted Source
Go to source

Translational Research

The Journal of Laboratory and Clinical Medicine

Trusted Source
Go to source


An All-science Publisher

Trusted Source
Go to source

Journal of Translational Medicine

BioMed Central

Part of Springer Nature
Go to source

Federal Trade Commission

Protecting America's Consumers

Trusted Source
Go to source

National Human Genome Research Institute

Database From National Institute Of Health

Trusted Source
Go to source

Food Production, Processing and Nutrition

BioMed Central

Part of Springer Nature
Go to source

BMC Gastroenterology

BioMed Central

Part of Springer Nature
Go to source

ACS Publications

A Division of The American Chemical Society

Trusted Source
Go to source

Annual Reviews

Independent, Non-profit Academic Publishing Company

Trusted Source
Go to source


National Center for Biotechnology Information

National Library of Medicine
Go to source

PLOS Journals

Nonprofit Publisher of Open-access Journals

Trusted Source
Go to source

Thieme E-books & E-Journals

Peer-reviewed & Open Access Journal

Trusted Source
Go to source

European Journal of Agriculture and Food Sciences

Peer-reviewed International Journal Publishes

Trusted Source
Go to source

Royal Society of Chemistry Publishing Home

Chemical Science Journals, Books and Database

Trusted Source
Go to source


Publisher of Peer-reviewed Articles in Open Acess Journals

Trusted Source
Go to source

De Gruyter

German Scholarly Publishing House

Trusted Source
Go to source


Open Access Research Journals & Papers

Trusted Source
Go to source

Oilseeds and Fats, Crops and Lipids

EDP Sciences

Trusted Source
Go to source

Cambridge Core

Cambridge University Press

Trusted Source
Go to source

FoodData Central

U.S. Department Of Agriculture

Trusted Source
Go to source

Journal of the American Heart Association

Peer-reviewed Open Access Scientific Journal

Trusted Source
Go to source

National Center for Complementary and Integrative Health

Database From National Institute Of Health

U.S Department of Health and Human Services
Go to source

The Americans with Disabilities Act

U.S. Department of Justice Civil Rights Division

Trusted Source
Go to source

Journal of the Academy of Nutrition and Dietetics

Organization of Food and Nutrition Professionals

Go to source

Sage Journals

Database From Sage Publications

Trusted Source
Go to source

National Institute of Drug Abuse

Database From National Institute Of Health

U.S Department of Health and Human Services
Go to source

The ClinMed International Library

A Repository and an Open Access Publisher for Medical Research

Trusted Source
Go to source

The Royal Society Publishing

United Kingdom's National Academy of Sciences

Trusted Source
Go to source

APA PsycNet

Database From American Psychological Association

Trusted Source
Go to source

The Pharma Innovation Journal

Peer-reviewed And Refereed Journal

Trusted Source
Go to source

Asian Journal of Pharmaceutical Research and Development

Peer-reviewed Bimonthly Journal

Trusted Source
Go to source

British Pharmacological Society

Journals - Wiley Online Library

Trusted Source
Go to source

American Psychological Association

Scientific and Professional Organization of Psychologists

Trusted Source
Go to source

AAP Publications

Database From American Academy of Pediatrics

Trusted Source
Go to source

Karger Publishers

Academic Publisher of Scientific and Medical Journals and Books

Trusted Source
Go to source

Cambridge University Press & Assessment

Database From Cambridge University

Trusted Source
Go to source

National Institute of Mental Health

Database From National Institute Of Health

U.S. Department of Health and Human Services
Go to source


Publisher of Open Access Journals

Trusted Source
Go to source

Bulletin of the National Research Centre

Part of Springer Nature

Trusted Source
Go to source

The New England Journal of Medicine

Massachusetts Medical Society

Trusted Source
Go to source

Economic Research Service


Trusted Source
Go to source


Database From National Library of Medicine

U.S Department of Health and Human Services
Go to source

National Institute of Health

An agency of the U.S. Department of Health and Human Services

Trusted Source
Go to source

Trusted Source

Database From National Institute Of Health

U.S Department of Health and Human Services
Go to source


Weekly Peer-reviewed Medical Trade Journal

The British Medical Association
Go to source

The British Psychological Society

The British Psychological Society is a charity registered in England

Database From Wiley Online Library
Go to source

National Heart, Lung, and Blood Institute

Database From National Institute Of Health

U.S Department of Health and Human Services
Go to source


Database From National Institute Of Health

U.S National Library of Medicine
Go to source


Database From National Institute Of Health

U.S National Library of Medicine
Go to source

Google Scholar

Go to source

Science.gov: USA.gov for Science

Government Science Portal

Go to source


Social Network Service For Scientists

Find and share research
Go to source

American Heart Association

To be a rentless force for a world of longer, healthier lives

Go to source

BioMed Central

Research in progress

Go to source

JAMA Network

Home of JAMA and the Specialty Journals of the American Medical Association

Go to source

Springer Link

Database From Springer Nature Switzerland AG

Springer - International Publisher Science, Technology, Medicine
Go to source


Database from Office of Dietary Supplements

National Institutes of Health
Go to source

Federal Trade Commission

Bureaus of Consumer Protection, Competition and Economics
Go to source

Trusted Source

Database From U.S. Department of Health & Human Services

Governmental Authority
Go to source

Oxford Academic Journals

Oxford University Press

Trusted Source
Go to source

Taylor & Francis Online

Peer-reviewed Journals

Academic Publishing Division of Informa PLC
Go to source


Database from World Health Organization

Go to source

Journal of Neurology

Peer-reviewed Medical Journal

American Academy of Neurology Journal
Go to source


Bibliographic Database of Scientific and Medical Publications

Dutch publisher Elsevier
Go to source

Wiley Online Library

American Multinational Publishing Company

Trusted Source
Go to source

Centers for Disease Control and Prevention

U.S. National Public Health Agency

U.S Department of Health and Human Services
Go to source

Trusted Source

Database from U.S. National Library of Medicine

U.S. Federal Government
Go to source

U.S. Food & Drug Administration

Federal Agency

U.S Department of Health and Human Services
Go to source

PubMed Central

Database From National Institute Of Health

U.S National Library of Medicine
Go to source

Help us rate this article

Thank you for your feedback

Keep in touch to see our improvement