08:42am Saturday 21 October 2017

BPA may be factor in increasing asthma rates

In the study, maternal exposure to 10 micro g/ml of BPA in mice enhanced the allergic sensitization and bronchial inflammation and responsiveness in their pups. This dosage mimics the human BPA burden of chronic exposure, including that of pregnant women.

“Previous studies indicated that maternal exposure in mice to environmental BPA enhanced the susceptibility of their pups to allergic asthma,” said study co-author Terumi Midoro-Horiuti, MD, PhD. “The goal of this study was to determine the actual threshold of the effects of BPA on allergic sensitization, airway inflammation and hyper-responsiveness.”

Female mice received 0, 0.1, 1 and 10 micro g/ml of BPA in their drinking water from one week before pregnancy, during pregnancy and while nursing their pups, in the study conducted at The University of Texas Medical Branch at Galveston.

BPA is a chemical commonly found in polycarbonate plastic bottles and the aluminum lining of food and beverage cans. BPA production started about 40 years ago. This coincides with the prevalence of increasing asthma rates.

The AAAAI (www.aaaai.org) represents allergists, asthma specialists, clinical immunologists, allied health professionals and others with a special interest in the research and treatment of allergic and immunologic diseases. Established in 1943, the AAAAI has nearly 6,500 members in the United States, Canada and 60 other countries. To find an allergist/immunologist in your area, visit www.aaaai.org/physref.
 
Editor’s notes:
 
  • This study was presented during the 2010 Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI) on February 26-March 2 in New Orleans. However, it does not necessarily reflect the policies or the opinions of the AAAAI.
  • A link to all abstracts presented at the Annual Meeting is available at annualmeeting.aaaai.org

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Contact:

Megan Brown
mbrown@aaaai.org
(414) 272-6071 (AAAAI executive office)

(504) 670-5113 (Press room, Ernest N. Morial Convention Center, February 26-March 2)

(Abstract: 502)


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