11:12pm Saturday 21 October 2017

Leicester research offers hope for developing new medicines

Understanding how cells communicate has a real-world application in drug development for treating a wide range of diseases.

In his free lecture on Tuesday 24 May Professor Nick Brindle, from the Department of Cardiovascular Sciences at the University of Leicester, will discuss some of his work into how cells function and how this knowledge benefits the health care industry. 

A specialist in cell signalling, Professor Brindle will explain how understanding the complex intercommunications between cells helps with treating cardiovascular and other diseases, repairing damaged tissue and has potential for growing replacement body parts.

Professor Brindle explained:

“I will focus particularly on the communication pathways that maintain the cardiovascular system, how problems with these pathways can lead to disease and how we can target parts of these communication systems to develop new medicines. 

“In addition I will discuss how we can rewire cell communication pathways and even create completely synthetic communication systems to control cells and non-biological nanoscale devices. 

“I hope the lecture will help people to recognize the importance of some of these signalling pathways for development of new medicines and the potential for harnessing the principles of biological communication systems in nanotechnology.”

The lecture ‘Cell signalling, from molecular mechanisms to medicines and beyond’, which is free and open to the public, will be held at 5.30pm in Lecture Theatre 1 in the Ken Edwards Building, University of Leicester.

Notes to Editors

For more information please contact Professor Nick Brindle at npjb1@le.ac.uk  or 0116 252 8502

Biography

Following a first degree at the University of Leeds Professor Brindle undertook a PhD in Biochemistry at the University of Manchester. His PhD studies, supervised by Chris Pogson and Victor Zammit, were into the transmembrane enzyme CPT1 and regulation of lipid metabolism. After this he spent year in the US followed by postdoctoral research at the University of Cambridge with Ken Siddle and Nick Hales. This was the beginning of his work on receptor tyrosine kinase signalling and he focussed on mechanisms of signalling by the insulin receptor. 

Professor Brindle then spent a short time at the MRC centre/Laboratory of Molecular Biology in Cambridge, working on signalling by insect glutamate receptors, and from there was appointed to a Lectureship at the University of Wales College of Medicine. It was at UWCM that he started applying his work on signalling to the cardiovascular system. In 1994 he moved to Leicester where he has established one of the leading international groups in receptor tyrosine kinase signalling in the cardiovascular system. 

Violetta Mertins


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