01:43am Friday 20 October 2017

New insight in how cells' powerhouse divides

The work, which could have implications for a wide range of diseases and conditions, was published today (Sept. 2) in the journal Science.

“It’s a paradigm shift in cell biology,” said Jodi Nunnari, professor and chair of molecular cell biology at UC Davis and a co-author of the paper.

Mitochondria produce chemical energy for a cell’s needs. They are wrapped in two membranes, have their own DNA, and can divide to produce new mitochondria. When this division is not properly controlled, it can result in cell death. Defects in mitochondria have been linked to a wide range of degenerative conditions and diseases, including diabetes, cardiovascular disease and stroke.

The research team led by Gia Voeltz, assistant professor in the Department of Molecular Cell and Developmental Biology at CU-Boulder, and Nunnari, at UC Davis, investigated how another structure in the cell, the endoplasmic reticulum or ER, is related to mitochondrial division.

The ER is a complex network of sacs and tubules that spreads out from the nucleus and is distributed throughout the cell. It is thought to play a role in a range of cell processes, including making secretory protein and lipids, and transporting molecules around the cell.

The team found that in both yeast and mammalian cells, mitochondrial division overwhelmingly occurred at points where the two structures, mitochondria and ER, touched.

Previous work by Nunnari’s lab and others has shown that mitochondrial division is regulated by dynamin related protein-1, which assembles into a ligature that tightens around the sausagelike mitochondrion and causes it to divide.

Nunnari and Voeltz found that these and other proteins linked to mitochondrial division were also found where the ER and mitochondria touched. Their study indicates that ER tubules first squeeze the mitochondrion, then dynamin-related proteins assemble on the surface to complete the job. This new function for the ER expands and transforms our view of cell organization, Nunnari said.

Co-authors of the paper are Jonathan Friedman, Matthew West and Jared DiBenedetto at CU-Boulder, and Laura Lackner at UC Davis. The work was funded by grants from the National Institutes of Health, the Searle Scholars Program and CU-Boulder.

About UC Davis

For more than 100 years, UC Davis has engaged in teaching, research and public service that matter to California and transform the world. Located close to the state capital, UC Davis has more than 32,000 students, more than 2,500 faculty and more than 21,000 staff, an annual research budget that exceeds $678 million, a comprehensive health system and 13 specialized research centers. The university offers interdisciplinary graduate study and more than 100 undergraduate majors in four colleges — Agricultural and Environmental Sciences, Biological Sciences, Engineering, and Letters and Science. It also houses six professional schools — Education, Law, Management, Medicine, Veterinary Medicine and the Betty Irene Moore School of Nursing.

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