11:03am Saturday 11 July 2020

Researchers identify nerves associated with deadly tropical disease

The disease, caused by toxins found in reef fish called ciguatoxins, is the world’s most common form of non-bacterial food poisoning, affecting 50,000-500,000 people each year.

The most prominent symptom of ciguatera is cold allodynia, a disorder where exposure to cool objects or water causes severe burning pain and electric shock-like sensations.

There is currently no cure.

The research team, which was led by Professor Richard Lewis and Dr Irina Vetter and included colleagues from Friedrich-Alexander-University of Erlangen-Nuremberg in Germany, examined the effect of ciguatoxins on the body’s nervous system.

In a detailed study of nerve channels, the team found that ciguatoxins don’t directly affect the channels responsible for sensing pain and cold.

“We identified the channels in the nervous system that the ciguatoxins act on, which in turn activate the nerves that sense cold and pain,” Dr Vetter said.

“It’s the first time anyone has established the molecular and cellular basis of ciguatoxin-induced cold pain and may lead to a treatment for this symptom.”

The first recorded incident of ciguatera was in 1774, when British sailors led by Captain James Cook were exploring the coast of Vanuatu and experienced a peculiar type of poisoning after eating fish.

In addition to the burning pain associated with cool temperatures, ciguatera also causes nausea, diarrhoea, intense itchiness and abdominal pain.

The discovery was reported in EMBO Journal and supported by the Australian Research Council, the National Health and Medical Research Council, the International Association for the Study of Pain and the Go8 Australia-Germany Joint Research Co-operation Scheme.

For more information or to donate to Professor Lewis’s lab, please call 07 3346 2132 or email [email protected]

The Institute for Molecular Bioscience (IMB) is a research institute of The University of Queensland that aims to improve quality of life by advancing personalised medicine, drug discovery and biotechnology.

Media contact:
Bronwyn Adams, IMB Communications Officer –07 3346 2134

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