Chikungunya virus is an emerging virus that in 2005 caused, for the first time, an outbreak in La Réunion island, a French overseas district where more than 30% of the population was infected, and has recently emerged in temperate regions of Europe. The identification of this new host factor enriches our understanding of the molecular bases of Chikungunya virus infection, which were characterized so far. This work also paves the way for the development of a more relevant humanized animal model to better understand the pathophysiology of infection. This research has been published online on April 26, at the European Molecular Biology Organization reports (EMBO reports).
Species-specific impact of the autophagy machinery on Chikungunya virus infection, European Molecular Biology Organization reports, April 26, 2013
Delphine Judith (1,7), Serge Mostowy (2,8), Mehdi Bourai (3), Nicolas Gangneux (1,7), Mickael Lelek (4,9), Marianne Lucas-Hourani (3), Nadège Cayet (5), Yves Jacob (6), Marie-Christine Prevost (5), Philippe Pierre (10,11), Frédéric Tangy (3), Christophe Zimmer (4,9), Pierre-Olivier Vidalain (3), Thérèse Couderc (1,7) & Marc Lecuit (1,7,12,13)
(1) Institut Pasteur, Biology of Infection Unit,
(2) Institut Pasteur, Bacteria-Cell Interactions Unit,
(3) Institut Pasteur, Viral Genomic and Vaccination Unit,
(4) Institut Pasteur, Computational and Imaging and Modeling Unit,
(5) Institut Pasteur, Ultrastructural Microscopy Platform,
(6) Institut Pasteur, Genetic, Papillomavirus and Human Cancer Unit,
(7) Inserm U1117, Institut Pasteur, Biology of Infection Unit,
(8) Inserm U604, INRA USC2020, Institut Pasteur, Bacteria-Cells Interactions Unit,
(9) CNRS UMR2582, Institut Pasteur, Computational and Imaging and Modeling Unit,
(10) Centre d’Immunologie de Marseille-Luminy, Universite de la Mediterranee,
(11) Inserm U631, CNRS UMR6102, Centre d’Immunologie de Marseille-Luminy, Marseille,
(12)Paris Descartes University, Sorbonne Paris Cite, Institut Imagine,
(13) Necker-Enfants Malades University Hospital, APHP, Division of Infectious Diseases and Tropical Medicine.