They have shown that dectin-1 and mannose receptors participate in the protection against the parasite responsible for this infection, by triggering an inflammatory response, while the DC-SIGN receptor facilitates the penetration of the pathogen and its proliferation in macrophages1. This work, conducted on both mice and humans and published on 16 May 2013 in the journal Immunity, opens new perspectives for the prevention and treatment of this disease.
1A macrophage is a cell of the immune system, located in tissues that can be subject to infection or an accumulation of debris that needs to be eliminated (liver, lungs, lymphatic ganglions, spleen, etc.), and which has in particular a phagocytosis function, in other words the ability to ingest and destroy parasites, bacteria, yeasts, cell debris, etc.
Divergent roles for C-type lectin receptors in the modulation of host cell response to Leishmania infantum. Lefèvre L, Lugo-Villarino G, Meunier E, Valentin A, Olagnier D, Authier H, Duval C, Dardenne C, Bernad J, Lemesre JL, Auwerx J, Neyrolles O, Pipy B, & Coste A, Immunity, 16 May 2013.