12:01am Thursday 16 July 2020

Penn Research Team Designs Novel Variant of Main Painkiller Receptor

The study was led by Renyu Liu, MD, PhD, assistant professor, Department of Anesthesiology and Critical Care, and Jeffery Saven, PhD, associate professor, Department of Chemistry. Jose Manuel Perez-Aguilar, then a graduate student in the Department of Chemistry, and Jin Xi, Felipe Matsunaga and Xu Cui, lab members in the Department of Anesthesiology and Critical Care, along with Bernard Selling of Impact Biologicals Inc., contributed significantly to this study.

The research was supported by the Foundation for Anesthesia Education and Research, Perelman School of Medicine’s Department of Anesthesiology and Critical Care, Mary Elizabeth Groff Foundation, National Institutes of Health and National Science Foundation through Penn’s Nano/Bio Interface Center and Penn’s Materials Research Science and Engineering Center.

For more information, please see the University of Pennsylvania press release.


Penn Medicine is one of the world’s leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation’s first medical school) and the University of Pennsylvania Health System, which together form a $4.3 billion enterprise.

The Perelman School of Medicine has been ranked among the top five medical schools in the United States for the past 16 years, according to U.S. News & World Report‘s survey of research-oriented medical schools. The School is consistently among the nation’s top recipients of funding from the National Institutes of Health, with $398 million awarded in the 2012 fiscal year.

The University of Pennsylvania Health System’s patient care facilities include: The Hospital of the University of Pennsylvania — recognized as one of the nation’s top “Honor Roll” hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital — the nation’s first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2012, Penn Medicine provided $827 million to benefit our community.

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