The discovery of this marker will increasing our understanding of parasite resistance to artemisinin derivatives, improved monitoring of the spread of resistant forms of malaria, and the swift adaptation of effective treatment methods to combat this disease. This research was published online December 18, 2013 by the journal Nature.
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria, Nature, published online December 18, 2013.
Frédéric Ariey (1,2,3), Benoit Witkowski (4), Chanaki Amaratunga (5), Johann Beghain (1,3,6), Anne-Claire Langlois (1,3), Nimol Khim (4), Saorin Kim (4), Valentine Duru (4), Christiane Bouchier (7), Laurence Ma (7), Pharath Lim (4,5,8), Rithea Leang (8), Socheat Duong (8), Sokunthea Sreng (8), Seila Suon (8), Char Meng Chuor (8), Denis Mey Bout (9), Sandie Ménard (10), William O. Rogers (11), Blaise Genton (12), Thierry Fandeur (1,4), Olivo Miotto (13,14,15), Pascal Ringwald (16), Jacques Le Bras (17), Antoine Berry (10), Jean-Christophe Barale (1,3), Rick M Fairhurst (5), Françoise Benoit-Vical (18,19), Odile Mercereau-Puijalon (1,3), Didier Ménard (4).
(1) Institut Pasteur, Parasite Molecular Immunology Unit, Paris, France
(2) Institut Pasteur, Genetics and Genomics of Insect Vectors Unit, Paris, France
(3) French National Center for Scientific Research (CNRS), Associated Research Unit 2581, Paris, France
(4) Institut Pasteur in Cambodia, Malaria Molecular Epidemiology Unit, Phnom Penh, Cambodia
(5) Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
(6) Institut Pasteur, Functional Genetics of Infectious Diseases Unit, Paris, France
(7) Institut Pasteur, Genomics Platform, Genomes and Genetics Department, Paris, France
(8) National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
(9) SSA WHO, Drug Monitoring in Cambodia, National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
(10) Toulouse-Purpan Pathophysiology Center, INSERM UMR1043 – CNRS UMR5282 – University of Toulouse III, and Parasitology and Mycology Department, Toulouse University Teaching Hospital, Toulouse, France
(11) Naval Medical Research Unit #2 Detachment, Phnom Penh, Cambodia
(12) Infectious Disease Service & Department of Ambulatory Care and Community Medicine, University of Lausanne, and Swiss Tropical and Public Health Institute, Basel, Switzerland
(13) MRC Centre for Genomics and Global Health, University of Oxford, Oxford OX3 7BN, UK
(14) Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok 10400, Thailand
(15) Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
(16) Global Malaria Program, World Health Organization, Geneva, Switzerland
(17) French National Reference Center for Malaria, Bichat-Claude Bernard Teaching Hospital, Paris Public Hospital Network (APHP), Research and Higher Education Cluster (PRES) Sorbonne Paris Cité, Faculty of Pharmacy, and Mother and Child Faced with Tropical Infections, IRD joint research unit 216, Paris, France
(18) French National Center for Scientific Research, Coordination Chemistry Laboratory UPR8241, Toulouse, France
(19) University of Toulouse, Paul Sabatier University, INPT, Toulouse, France