Some of these common human gene variants are already known to be risk factors for diabetes mellitus. The pathomechanisms of diabetes have intrigued physicians and been the subject of much debate for many decades. These new research results may contribute to a better understanding of the clinical picture of diabetes and its pathogenesis – and could lead to new approaches in early diagnosis and therapy. The findings have been published in the current online issue of the renowned journal Nature Genetics.
The research team, made up of scientists of the Institute of Bioinformatics and Systems Biology at Helmholtz Zentrum München and of Ludwig-Maximilians-Universität München (LMU) and led by Professor Karsten Suhre, identified variants in nine different genes which could be associated with disturbances in the lipid metabolism. Together with Dr. Christian Gieger and Assistant Professor Thomas Illig of the Institute of Epidemiology at Helmholtz Zentrum München, Professor Suhre succeeded for the first time in associating variants in the well-known diabetes risk genes MTNR1B and GCKR with changes in the metabolism. “The results of our study bring us a decisive step closer in our search for markers for the early detection and therapy of serious metabolic diseases such as diabetes,” Professor Suhre explained.
The variants identified in the study usually cause differences in the metabolization of important lipid building blocks of the body. Moreover, many of the identified variants are already known to be associated with elevated disease risk, for example for metabolic disorders – first and foremost for diabetes.
As first step, the research team determined the concentrations of 163 metabolic products in blood samples of 1,800 participants of the KORA population study. Next, they investigated the metabolic profiles in a genome-wide association study for possible associations with common gene variants (SNPs). Then the scientists confirmed the identified associations by repeating their experiments in an independent study. The replication study took place in cooperation with scientists of the Sanger Centre in Hinxton and King’s College in London, based on the British population study TwinsUK.
Karsten Suhre’s research work belongs to the young research field of metabolomics in which scientists determine the concentrations of as many metabolic products (metabolites) as possible. In individuals with different gene variants, the affected enzymes also vary in their activity, and the concentrations of the metabolic products differ. The relationships are then categorized into distinct genetically determined metabotypes which can react differently to external environmental influences such as nutrition and other living conditions. In this way the metabolomics experts can identify risk patients for metabolic disorders earlier than they could previously. Thus, this study was able to detect genetically caused metabolic processes which play a crucial role in the pathogenesis as well as in the diagnosis and therapy of diseases such as diabetes.
Prof. Dr. Karsten Suhre
Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München
Phone: +49 (0) 89 3187-2627, e-mail: firstname.lastname@example.org
Head, Communications Department, Helmholtz Zentrum München
Helmholtz Zentrum München, Ingolstädter Landstr. 1, 85764 Neuherberg, Germany
Phone: +49 (0) 89 3187 – 3946, Fax +49 (0) 89 3187 – 3324, e-mail: email@example.com
Original Publication: Illig T, Gieger C, Suhre K et al. A genome-wide perspective of genetic variation in human metabolism, Nature Genetics, online DOI: 10.1038/ng.507.
Upcoming Event: March 10-12, 2010: 1. International Metabolomics Symposium in Germany. – Metabolomics & More – The Impact of Metabolomics on the Life Sciences. Freising-Weihenstephan. Further information… | Attention: With extra press workshop on March 10, 2010: Further information…
The Institute of Bioinformatics and Systems Biology (Director: Prof. Dr. Werner Mewes) of Helmholtz Zentrum München conducts research on the systematic functional and structural analysis of proteins, focusing on the characterization of model genomes such as yeast, Arabidopsis thaliana and the mouse. The main goal is to develop methods to interpret molecular biological data and to predict information which cannot be directly calculated by using algorithms from the sequence. Further information…
Research in the Institute of Epidemiology (Director: Prof. Dr. H.-Erich Wichmann) at Helmholtz Zentrum München focuses on methodological problems related to the quantification of small risks, the impact of particles and airborne pollutants on the lung and the cardiovascular system, and the regional distribution and development of diseases of the respiratory tract and allergies. A new focus of the Institute is the molecular analysis of complex diseases (e.g. asthma, type 2 diabetes, cardiac infarction). The main aim is to investigate the role of environmental factors and genetic disposition in human health using epidemiological methods. Further information…
KORA (Cooperative Health Research in the Region of Augsburg, Director: Prof. Dr. H.-Erich Wichmann) is a research platform for population-based health research in the fields of epidemiology, health economics, and health care research. KORA is a network of population-representative surveys and follow-up studies. The unique feature of this platform is the extensive participation of external partners in the planning, implementation and financing of the individual projects. Further information…
Helmholtz Zentrum München is the German Research Center for Environmental Health. As leading center oriented toward Environmental Health, it focuses on chronic and complex diseases which develop from the interaction of environmental factors and individual genetic disposition. One key area of research is diabetes mellitus. Helmholtz Zentrum München has around 1700 staff members. The head office of the center is located in Neuherberg to the north of Munich on a 50-hectare research campus. Helmholtz Zentrum München belongs to the Helmholtz Association, Germany’s largest research organization, a community of 16 scientific-technical and medical-biological research centers with a total of 26,500 staff members.