An international team that includes KTH researchers Christina Al-Khalili Szigyarto and Mathias Uhlén report that they discovered how to create a variant of dystrophin that can mitigate muscle atrophy. This could in turn lead to the development of new therapies for muscular dystrophy.
The research was
Duchenne muscular dystrophy results from a lack, or impaired function, of the protein dystrophin, a major component of muscles. Dystrophin plays a significant role in, among other things, cardiovascular functioning.
The incurable disease causes a progressive degeneration process of the muscles, resulting in decreased mobility, breathing problems, heart failure and, ultimately, a premature death.
Uhlén, a professor of microbiology at KTH, says the research team demonstrated the presence of so-called native and truncated dystrophin with the help of HPA antibodies in muscle.
“Then the protein is run through a gel, extracted and sequenced by mass spectrometry,” Uhlén says. “The resulting sequences of the native and the truncated dystrophin protein have been compared on the level of amino acid.
“We have been able to demonstrate that in comparison with healthy people, the patients in the study manufacture a shorter version of the dystrophin protein despite a severe mutation in the dystrophin gene.”
For more information, contact Mathias Uhlén at firstname.lastname@example.org or Christina Al-Khalili Szigyarto at 08 – 55 37 88 32.