05:53am Saturday 19 August 2017

Legal high sensor to combat new drugs

Dr Oliver Sutcliffe displays the new legal high sensor

CHEMISTS have developed the first portable and reliable ‘legal high’ detector to instantly analyse the new range of recreational drugs appearing across the country.

Scientists at Manchester Metropolitan University (MMU) have created a hand-held sensor to rapidly detect legal highs because current drug tests do not recognise these new chemicals.

The synthetic drugs – which often masquerade under innocuous sounding names such as ‘plant food’ or ‘glass cleaner’ – first appeared around five years ago. Many were initially legal before legislators outlawed them.

So chemists at MMU developed a low-cost electrochemical sensor to detect legal highs, also known as New Psychoactive Substances (NPS), publishing their results in the journal Analytical Chemistry.

On-the-spot detection

Dr Oliver Sutcliffe, Professor Craig Banks and colleagues created environmentally-friendly mercury-free electrodes and calibrated the results against ‘gold-standard’ detection equipment in laboratories to ensure accuracy.

Dr Sutcliffe said: “It will potentially be a first-line field detection for police and other agencies. It would be able to establish, on the spot, whether a substance is an NPS instead of the time-consuming task of lab tests.”

The sensors find the unique electrochemical fingerprint of the cathinone branch of chemicals, which are similar to amphetamines. The substances first came to the public’s attention in 2010 when a derivative, mephedrone, hit the headlines after it was made illegal.

But many of the legal highs appear in new forms as their chemical structures or formulations are tweaked to circumvent current drug laws. While some of the original NPSs, now classified as controlled substances, still exist illegally.

‘Quick and reliable’

This poses a problem for in-the-field detection as traditional drug detection techniques do not work on the new wave of legal highs.

“There are a lot of presumptive tests that the police do but they are simple colour change tests where a sample reacts with a specific chemical to produce either a positive or negative result,” added Dr Sutcliffe.

“The problem is that at the moment there are new classes of legal highs coming on to the market, but there just aren’t any specific chemical tests available for some of the compounds or they interfere with existing presumptive tests.

“These detectors are, potentially, another weapon in the arsenal and could replace colour change tests for something that’s quicker and more reliable.”

Researchers tested both pre-ban cathinone samples and seized street cathinone samples. Tests showed that even when the legal high samples were mixed with diluents, such as caffeine and benzocaine, the sensors were still able to detect the illicit cathinone derivatives at low concentrations.

Manchester Metropolitan University is a leading university for the professions and a powerful driver of the North West economy.

The University educates and trains large numbers of the region’s legal and business professionals, scientists, engineers, teachers, health workers and creative professionals. It enjoys an excellent reputation for teaching and applied research and is a recognised innovator in partnership working with its local communities. The University is currently investing almost £300 million in its estate and facilities.


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