The research has revealed, for the first time, a causal relationship between a vital pumping system that does not function correctly in people with cystic fibrosis and the parasite Toxoplasma. The new knowledge from these research findings paves the way for the development of new drugs to treat respiratory diseases.
A team of researchers from the University of Salford, led by Professor Geoff Hide, Professor of Parasitology at the School of Environment & Life Sciences, has worked with researchers from the Universities of Sun Yat-Sen, China and California in a study of the Toxoplasma gondii parasite. The parasite is one of the most common in humans.
The team found that the Toxoplasma gondii parasite causes the chloride pumping system, which releases chloride irons to produce a surface liquid lining in order to prevent airborne pathogens from being inhaled, not to work.
In people with cystic fibrosis and pneumonia, this pump does not work. This defect is linked to infection by the Toxoplasma gondii parasite.The research has revealed that a receptor called ‘P2Y2-R’, which picks up the signals to switch on this pump, is blocked when infected by the Toxoplasma gondii parasite.
Professor Hide believes that understanding the parasite is paramount for developing treatments in the future. He said: “This is a very important finding as this parasite is thought to infect around 10% of people in the UK and 30% of people globally.”
“While the parasite normally does not affect us, in some cases, such as, during pregnancy or immune system illnesses, it can cause considerable harm, including impairment of lung function.”
Professor Hide worked with Professor Zhao-Rong Lun, and Professor Francisco J Ayala to complete the report
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