Traffic accidents and severe falls can cause ruptures of nerve fibers that enter/exit the spinal cord. Most commonly, these avulsion injuries affect the innervation of the arm and hand, and lead to paralysis, loss of sensation and cause chronic pain. Surgical interventions can help the patient regain some muscle function, but there is currently no treatment able to restore sensory functions. The reason for this is the emergence of a “barrier” at the junction between the ruptured nerve fibers and the spinal cord which prevents them from growing into the spinal cord and restore lost nerve connections.
In a new study the PhD students Jan Hoeber, Niclas König and Carl Trolle, working in Dr.Elena Kozlova’s research group transplanted human stem cells to an avulsion injury in mice with the aim to restore a functional route for sensory information from peripheral tissues into the spinal cord.
The results show that the transplanted stem cells act as a ”bridge” which allows injured sensory nerve fibers to grow into the spinal cord, rebuild functional nerve connections, and thereby achieve long term restoration of major parts of the lost sensory functions. The transplanted stem cells differentiated to different types of cells with variable level of maturation, specific for the nervous system. No signs of tumor development or any functional abnormalities from the transplants were observed in the study, outcomes which are important in view of potential risks with transplantation of embryonic stem cells.
The results encourage further research on the use of stem cells for treatment of injury and disease in the spinal cord, and may contribute to the development of novel treatment strategies in these disorders.
The research has been led by associated professor Elena Kozlova’s research group in Regenerative Neurobiology at the Department of Neuroscience in collaboration with scientists from Australia, The Netherlands and the USA.
Human embryonic stem cell-derived progenitors assist functional sensory regeneration after dorsal root avulsion injury. Hoeber J, Trolle C, König N, Du Z, Gallo A, Hermans E, Aldskogius H, Shortland P, Zheng, S-C, Deumens R, Kozlova EN. Scientific Reports. 2015;