Professor David Henshall, from the RCSI Department of Physiology and Medical Physics and joint senior author on the study commented: “Epilepsy affects more than 37,000 people in Ireland and our study has shown promising results for the development of new treatments. We are looking forward to the next phase of the research which will potentially lead to a new type of drug that can tackle the underlying causes of epilepsy, reducing seizures and ultimately improving quality of life for people with the condition.”
The first author on the study is Dr Eva Jimenez, Research Fellow, who worked with joint senior authors Professor David Henshall and Dr Tobias Engel, Lecturer, all based at the RCSI Department of Physiology and Medical Physics and numerous international collaborators.
The findings are a result of a major four-year collaborative effort to investigate molecular mechanisms of epilepsy development. Led by the team in at RCSI in Dublin, the work features academic and industry collaborators including Universidad Complutense de Madrid, Spain; Robert S. Dow Neurobiology Laboratories, Legacy Research Institute, Portland, Oregon, USA and Janssen Research and Development, LLC, Neuroscience, San Diego, California USA .
The research was supported by a grant from Science Foundation Ireland’s (SFI) Starting Investigator Research Grant (SIRG) and by EpimiRNA, an international consortium funded by the EU FP7 programme, coordinated by RCSI.
RCSI is ranked 46th in the world for ‘International Outlook’ and #251 – 300 in the Times Higher Education World University Rankings (2015-2016). It is an international not-for-profit health sciences institution, with its headquarters in Dublin, focused on education and research to drive improvements in human health worldwide.
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