11:28pm Thursday 19 October 2017

Breakthrough in understanding cell development

For the first time, scientists have gained an insight into how this process is co-ordinated in plants. An international team, including Cardiff University’s School of Biosciences and Duke University in the USA, have linked the process of cell division with the way cells acquire their different characteristics.

A protein called Short-root, already known to play a part in determining what cells will become, was also found to control cell division.

The researchers report their findings on July 1 in the journal Nature. The discovery may have implications for animals and improve our understanding of what happens when organs are deformed.

The research team had already studied the molecular-level events that determine how particular cells in plants develop into different types. These events involve Short-root and another protein, Scarecrow.

Researchers also had a good understanding of the factors which allow cells to go through their cycle and divide into two daughter cells. “What was missing was a connection between the two,” according to Dr Rosangela Sozzani, a postdoctoral researcher at the Duke Institute for Genome Sciences and Policy, North Carolina, who was lead author of the new study.

The research team combined a number of experimental techniques and technologies to produce a dynamic view of the genetic events that Short-root and its partner Scarecrow set into motion within a single type of cell in Arabidopsis plants. They found that at the very same time that cells divide, Short-root and Scarecrow switch on the gene cyclin D6. Cyclin D6 is one of a family of genes that govern cell growth and division.

Professor Jim Murray, who led the Cardiff University involvement in the discovery, said: “Not only does this finding have practical significance to our understanding of how plants develop, this may also be a fundamental process which is relevant to animals as well. For example, we already know that cyclin D6 is present in humans. We also know that disruption of this process can lead to tumours or badly-formed organs, so it is vital that we know more about it.”



Notes to editors:

1. The paper Spationtemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth is published in Nature on July 1, 2010-06-29. The authors are:

R. Sozzani1*, H. Cui1*{, M. A. Moreno-Risueno1, W. Busch1, J. M. Van Norman1, T. Vernoux1{, S. M. Brady1{, W. Dewitte2, J. A. H. Murray2 & P. N. Benfey1

1Department of Biology and IGSP Center for Systems Biology, Duke University, Durham, North Carolina, USA. 

2. Cardiff School of Biosciences, Cardiff University 

{Present addresses: Department of Biological Science, Florida State University, Florida , USA ; Laboratoire Reproduction et Développement des Plantes, Université de Lyon, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon I, Centre National de la Recherche Scientifique, Institut National de la Recherche Agronomique, cedex 07, Lyon, France ; Section of Plant Biology and Genome Center, University of California, Davis, California, USA .

Funding to M.A. Morena-Risueno. is provided by the Ministerio de Ciencia y Innovacion (Spain). W Dewitte and J.A.H. Murrary were funded by a Biotechnology and Biological Sciences Research Council grant and the European Research Area in Plant Genomics network on Plant Stem Cells. This work was funded by grants to P.N. Benfey from the NIH and from the NSF.


For further information, please contact:

Stephen Rouse,

Public Relations Office,

Cardiff University.

029 2087 5596

e-mail: RouseS@cardiff.ac.uk

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