08:32am Sunday 24 September 2017

Size of hippocampus may indicate early dementia

Mild cognitive impairment, or MCI, is a condition where the cognitive functions are impaired – though not as severely as in dementia – and is a precursor to several types of dementia.

“One of the challenges for the healthcare is identifying which MCI patients have an underlying dementia disorder, which is why we need new tools to detect the early signs of dementia,” says Carl Eckerström, a researcher at the Sahlgrenska Academy’s Department of Psychiatry and Neurochemistry, and doctor at Sahlgrenska University Hospital’s memory clinic.

Atrophy of the hippocampus is common in Alzheimer’s disease. The thesis shows that the hippocampus may also be affected in small vessel disease (SIVD) which, along with Alzheimer’s, are the two most common types of dementia. SIVD is characterised by damage to the brain’s white matter and is considered to be the most important type of vascular dementia in the elderly.

Researchers measured the extent of changes to white matter in 122 MCI patients, and compared this with the size of their hippocampus. The patients were divided into two categories – one group who subsequently developed dementia after two years, and a second group whose clinical status remained unchanged after two years. There was also a group of healthy controls. The results showed that there may be a link between damage to the white matter and a reduction in the size of the hippocampus, which means that damage to the white matter could play a part in a process that leads to hippocampal atrophy.

“I believe that measuring the hippocampus could be a useful clinical instrument for investigating whether a person is in the early stages of dementia, as our findings suggest that the size of the hippocampus is linked to a deterioration in cognitive function and dementia,” says Eckerström.

THE HIPPOCAMPUS
The hippocampus is part of the limbic system and is located deep in the temporal lobe. It is vital for our ability to learn and is known as the brain’s memory centre. The hippocampus also helps with spatial awareness, enabling us to navigate our way around new places.

For more information, please contact:
Carl Eckerström, researcher at the Sahlgrenska Academy’s Department of Psychiatry and Neurochemistry, and doctor at Sahlgrenska University Hospital’s memory clinic, mobile: +46 (0)7 0440 0725, e-mail: Carl.eckerstrom@neuro.gu.se

Supervisors:
Åke Edman, docent at the Sahlgrenska Academy’s Department of Psychiatry and Neurochemistry, mobile: +46(0)7 0956 2662, e-mail: ake.edman@neuro.gu.se
Helge Malmgren, professor at the University of Gothenburg’s Department of Philosophy, Linguistics and Theory of Science, mobile: +46 (0)7 3314 5061, e-mail: helge.malmgren@filosofi.gu.se
Anders Wallin, professor at the Sahlgrenska Academy’s Department of Psychiatry and Neurochemistry, mobile: +46(0)7 0593 9551, e-mail: anders.wallin@neuro.gu.se

Doctoral thesis for the degree of PhD (Medicine) at the Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy.

Title of thesis: Hippocampal volumetry in mild cognitive impairment

The thesis has been successfully defended.

Link to thesis: hdl.handle.net/2077/22902

BY: Lena Mattsson 
031-786 38 69, 0760- 24 82 70


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