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Restoring emotional memory in a rat model of major depressive disorder

The findings are published online in Molecular Psychiatry, and may provide a target for future antidepressant medications with procognitive actions.

Per Svenningsson Photo: Elnaz Alizadeh

Cognitive impairments, such as diminished concentration or indecisiveness, are common in patients with MDD, but these symptoms have been difficult to model in animal studies. Per Svenningsson, Therese Eriksson and colleagues determined that the rat depression model, Flinders Sensitive Line (FSL), exhibit comparable cognitive dysfunctions, such as impaired emotional memory processing, and fail to avoid an unpleasant environment. After chronic treatment with the SSRI escitalopram – but not the tricyclic antidepressant nortriptyline – memory performance was restored.

The authors identified the molecular nodal points whereby the SSRI was effective, which could provide a target for future antidepressant medications with procognitive actions.

Publication:

TM Eriksson, P Delagrange, M Spedding, M Popoli, A Mathé, SO Ögren & P Svenningsson

Emotional memory impairments in a genetic rat model of depression: involvement of 5-HT/MEK/Arc signaling in restoration

Molecular Psychiatry, online 18 januari 2011, DOI: MP.2010.131

For further information, please contact:

Doctoral Student Therese M Eriksson

Work:
+46 (0)8-51774614
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