02:29am Wednesday 20 September 2017

Nerve cells grown from stem cells give new insight into Parkinson’s

Skin biopsy taken from a patient with Parkinson’s disease.

Image 01: Skin biopsy taken from a patient with Parkinson’s disease. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

Skin cells grow out of the biopsy

Image 02: Skin cells grow out of the biopsy. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

Further growth of the skin cells, or ‘fibroblasts’

Image 03: Further growth of the skin cells, or ‘fibroblasts’. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

A colony of induced pluripotent stem cells (iPSC) forms after the skin cells have been reprogrammed.

Image 04: A colony of induced pluripotent stem cells (iPSC) forms after the skin cells have been reprogrammed. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

The stem cells develop, or ‘differentiate’, into neurons – day 1

Image 05: The stem cells develop, or ‘differentiate’, into neurons – day 1. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

Differentiating cells – day 5

Image 06: Differentiating cells – day 5. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

Differentiating cells – day 9

Image 07: Differentiating cells – day 9. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

Differentiating cells – day 21

Image 08: Differentiating cells – day 21. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

On day 25, cells that have become neurons are seen here in red

Image 09: On day 25, cells that have become neurons are stained here in red. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

Neurons that show up as green here produce dopamine – the type of neuron involved in Parkinson’s disease.

Image 10: Neurons that show up as green here produce dopamine – the type of neuron involved in Parkinson’s disease. Credit: OU/Richard Wade-Martins.

A larger version of this image is available here.

For more information contact the University of Oxford Press Office on +44 (0)1865 280530 or email press.office@admin.ox.ac.uk


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