03:06pm Monday 24 February 2020

Lifelong Depression May Increase Risk of Vascular Dementia, While Late-Life Depression May Signal Alzheimer's Disease

The study, which appears in the current issue of the Archives of General Psychiatry, is the first to examine whether midlife or late-life depression is more likely to lead to either Alzheimer’s disease or vascular dementia in the long term. The researchers explain that vascular dementia, the second most common type of dementia, develops when impaired blood flow to parts of the brain deprives cells of nutrients and oxygen. 

“People who had depressive symptoms in both midlife and latelife were much more likely to develop vascular dementia, while those who had depressive symptoms in latelife only were more likely to develop Alzheimer’s disease,” said the study’s lead author Deborah E. Barnes, PhD, MPH, with the UCSF Departments of Psychiatry and Epidemiology & Biostatistics and the San Francisco Veterans Affairs Medical Center. 

“The findings have important public health implications because they raise hope that adequate treatment of depression in midlife may reduce dementia risk, particularly vascular dementia, later in life,” added Rachel Whitmer, PhD, a research scientist at the Kaiser Permanente Northern California Division of Research and the principal investigator of the study. 


UCSF and Kaiser Permanente investigators examined the association between depressive symptoms and dementia over the course of 45 years in a longitudinal study of more than 13,000 long-term members of the Kaiser Permanente Northern California integrated care delivery system. The study population consisted of members who participated in a voluntary health examination called the Multiphasic Health Checkup in San Francisco and Oakland during 1964-1973 when they were 40-55 years old. 

Participants were evaluated for depressive symptoms in midlife as part of the Multiphasic Health Checkup and again in latelife between 1994-2000. Between 2003-2009, 3,129 participants were diagnosed with dementia.   

Though more research is needed, the findings suggest that depression that begins in latelife may be an early symptom of Alzheimer’s disease, while chronic depression over the life course may reflect a long-term process of changes to blood flow in the brain associated with increased risk of vascular dementia. 

Additional authors on the paper include: Kristin Yaffe, MD, UCSF Departments of Psychiatry, Neurology and Epidemiology & Biostatistics and San Francisco Veterans Affairs Medical Center; Amy L. Byers, PhD, MPH, UCSF Department of Psychiatry and San Francisco Veterans Affairs Medical Center; Mark McCormick, MD, Kaiser Permanente Santa Clara Medical Center Department of Psychiatry; and Catherine Schaefer, PhD, Kaiser Permanente Division of Research. 

The study was funded by the Brain and Behavior Research Foundation (formerly the National Alliance for Research on Schizophrenia and Depression), the National Institutes of Health and Kaiser Permanente Community Benefit.

Kaiser Permanente Division of Research

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