05:23am Thursday 28 May 2020

Poor mental health linked to reduced life expectancy

A team of researchers from UCL (University College London) and the University of Edinburgh analysed data from more than 68 000 adults aged 35 years and over who took part in the Health Survey for England from 1994 to 2004.

Participants in the study had been evaluated for mental health problems using a recognised scale ranging from no symptoms to severe symptoms of depression and anxiety. The team then looked to see whether people who reported these symptoms during the study were more likely to have died over an eight-year period. They also examined whether there was an association with death from cardiovascular disease, cancer or from external causes of death.

Their results reveal that people who experienced symptoms of anxiety or depression had a lower life expectancy than those without any such symptoms. Even people with minor symptoms of mental health problems seemed to have a higher risk of death from several major causes, including cardiovascular disease.

Dr David Batty, a Wellcome Trust research fellow in the Department of Epidemiology and Public Health at UCL and senior author on the study, explains: “These associations also remained after we did our best to take into account other factors such as weight, exercise, smoking, alcohol consumption and diabetes. Therefore, this increased mortality is not simply due to people with higher levels of psychological distress having poorer health behaviours.”

There is a possibility that mental health problems may be associated with biological changes in the body that increase the risk of diseases such as heart disease.

In this study, approximately a quarter of people suffered from minor symptoms of anxiety and depression; however, these patients do not usually come to the attention of mental health services. The authors say that their findings could have implications for the way minor mental health problems are treated.

Dr Tom Russ, Alzheimer Scotland clinical research fellow at the University of Edinburgh, said: “The fact that an increased risk of mortality was evident, even at low levels of psychological distress, should prompt research into whether treatment of these very common, minor symptoms can reduce this increased risk of death.”

Previous studies investigating the association between symptoms of mental health and life expectancy have been small and unable to reliably measure thresholds of risk. This is the largest study to address the problem to date.

John Williams, Head of Neuroscience and Mental Health at the Wellcome Trust, said: “People with mental health problems are among the most vulnerable in society. This study highlights the need to ensure they have access to appropriate health care and advice so that they can take steps to improve the outcome of their illness.”

Understanding the brain and finding improved approaches for treating brain and mental health disorders is one of the Wellcome Trust’s five strategic research challenges.


Image: Digital artwork showing the human brain with Prozac capsules. Credit: Rowena Dugdale, Wellcome Images.



Jen Middleton
Media Officer
The Wellcome Trust
+44 (0)20 7611 7262
[email protected]

Notes for editors

Russ TC et al. Association between psychological distress and mortality: individual participant pooled analysis of 10 prospective cohort studies. BMJ 2012 (epub ahead of print).

About the Wellcome Trust
The Wellcome Trust is a global charitable foundation dedicated to achieving extraordinary improvements in human and animal health. It supports the brightest minds in biomedical research and the medical humanities. The Trust’s breadth of support includes public engagement, education and the application of research to improve health. It is independent of both political and commercial interests.

About UCL (University College London)
Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. We are among the world’s top universities, as reflected by performance in a range of international rankings and tables. UCL currently has 24,000 students from almost 140 countries, and more than 9,500 employees. Our annual income is over £800 million. Follow us on Twitter @uclnews.

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