08:10am Monday 18 November 2019

Researchers Identify Possible Treatment Window for Memory Problems

“Our study suggests that plaques in the brain that are linked to a decline in memory and thinking abilities, called beta amyloid, take about 15 years to build up and then plateau,” said Clifford R. Jack, Jr., MD, with the Mayo Clinic in Rochester, Minn.

For the study, 260 people between the ages of 70 and 92 underwent two or more brain scans over an average of 1.3 years that measured plaque buildup in the brain. Of the participants, 78 percent did not have impaired thinking abilities or memory at the start of the study.

The study found that the rate of buildup accelerates initially, then slows down before plateauing at high levels. For example, lower rates of plaque buildup were found in both people who had low and high levels of the plaques at the start of the study while the rate of plaque accumulation was highest in participants with mid-range levels at the start of the study.

The study also found that the rate of buildup of plaques was more closely tied to the total amount of amyloid plaques in the brain than other risk factors, such as the level of cognitive impairment, age and the presence of the APOE gene, a gene linked to Alzheimer’s disease.

“Our results suggest that there is a long treatment window where medications may be able to help slow buildup of the amyloid plaques that are linked to cognitive decline,” said Jack. “On the other hand, trying to treat the plaque buildup after the amyloid plaque load has plateaued may not do much good.”

The study was supported by the National Institutes of Health, National Institute on Aging and General Electric Corporation.

To learn more about cognition, visit http://www.aan.com/patients.

The American Academy of Neurology, an association of more than 25,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, brain injury, Parkinson’s disease and epilepsy. For more information about the American Academy of Neurology, visit http://www.aan.com or find us on Facebook, Twitter, Google+ and YouTube.


Trust Makes You Delusional and That’s Not All Bad

Trusting partners remember transgressions in ways that benefit the relationship

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February 27, 2013 | by Hilary Hurd Anyaso

EVANSTON, Ill. — Trust fools you into remembering that your partner was more considerate and less hurtful than he or she actually was.  

New research from Northwestern University and Redeemer University College (Ontario, Canada) is the first to systematically examine the role of trust in biasing memories of transgressions in romantic partnerships. 

People who are highly trusting tended to remember transgressions in a way that benefits the relationship, remembering partner transgressions as less severe than they originally reported them to be. People low on trust demonstrated the opposite pattern, remembering partner transgressions as being more severe than how they originally reported them to be. 

“One of the ways that trust is so good for relationships is that it makes us partly delusional,” said Eli J. Finkel, co-author of the study and professor of psychology at Northwestern.

Laura B. Luchies, lead author of the study, said the current psychological reality of your relationship isn’t what actually happened in the past, but rather the frequently distorted memory of what actually happened.  

“You can remember your partner as better or as worse than he/she really was, and those biased memories are important determinants of how you think about your partner and your relationship,” she said.

Researchers have long known that trust is crucial to a well-functioning relationship.  

“This research presents a newer, deeper understanding,” Finkel said. “It reveals that trust yields relationship-promoting distortions of the past.”

Said Luchies, assistant professor of psychology at Redeemer University College: “If you talk to people who really trust their partner now, they forget some of the negative things their partner did in the past. If they don’t trust their partner much, they remember their partner doing negative things that the partner never actually did. They tend to misremember.” 

Trust and Biased Memory of Transgressions in Romantic Relationships” was published online in the Journal of Personality and Social Psychology.

In addition to Luchies and Finkel, co-authors include Jennifer Wieselquist; Caryl E. Rusbult of Vrije Universiteit Amsterdam; Madoka Kumashiro of Goldsmiths, University of London; and Paul W. Eastwick of the University of Texas at Austin. 

– See more at: http://www.northwestern.edu/newscenter/stories/2013/02/trust-makes-you-delusional-and-thats-not-all-bad.html#sthash.q4w5R56H.dpuf

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