07:32am Saturday 19 October 2019

Suicide-related behavior: anti-epileptic drugs not direct cause

It doesn’t discount the link completely, said Mary Jo Pugh, Ph.D., an associate professor in the Department of Epidemiology and Biostatistics in the School of Medicine at The University of Texas Health Science Center at San Antonio, but it raises important questions about the association that has been codified in an FDA warning.

“I think what it suggests is that we need to be careful about attributing everything to a drug,” said Dr. Pugh, who is also a research health scientist for VA Health Services and Development Service, which funded the study.

Analysis of more than 90,000 military veterans’ records
Pugh and her fellow researchers analyzed the records of more than 90,000 older military veterans and published the findings in the Nov. 26, 2013, edition of Neurology, the medical journal of the American Academy of Neurology.

Many of the veterans who were prescribed anti-epileptic drugs had mental health conditions such as depression or bipolar disorder, and not all had epilepsy.

“This is a cohort that may be more likely to have suicidal ideation or attempts even before receiving the drug,” Dr. Pugh said. “Probably people with depression or mental health-related diagnoses need to be screened more carefully and checked more frequently.”

The results from this group also led to questions about how different drugs work in other age groups, she said.

“I think we need more information on specific kinds of drugs and younger patients,” Dr. Pugh said.

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The University of Texas Health Science Center at San Antonio, one of the country’s leading health sciences universities, ranks in the top 3 percent of all institutions worldwide receiving National Institutes of Health funding. The university’s schools of medicine, nursing, dentistry, health professions and graduate biomedical sciences have produced more than 29,000 graduates. The $765.2 million operating budget supports eight campuses in San Antonio, Laredo, Harlingen and Edinburg.

Contact: Elizabeth Allen, 210-450-2020

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