01:32am Sunday 17 February 2019

What’s stress got to do with it? How trauma-induced changes to gene function can lead to psychosis

Finding the answer to this is the focus of a new NHMRC-funded research project led by UNSW researcher, Associate Professor Melissa Green.

Green’s research will identify how trauma-induced changes in gene function affect the stress and immune-related systems in people with psychotic and mood disorders.

“The potential cascade triggered by early abuse likely contributes to the way our bodies and brain learn to respond to stress,” Green says, who is currently on an international fellowship at the Netherlands Institute for Advanced Study, collaborating with Dutch researchers at Leiden University.

“Identifying markers of trauma on the genome in people with psychosis who have been exposed to childhood trauma will help us better understand how psychotic disorders develop by this route.”

“These individuals may require different or additional treatments such as those used to treat Post-Traumatic Stress Disorder.”

Green’s earlier research found that schizophrenia patients who carried a specific type of genetic variant, and who were exposed to childhood trauma, showed worse impairments in cognition and more severe psychotic symptoms than other schizophrenia patients.

“We believe this finding could also be relevant to some people with bipolar or other mood disorders.”

Green is now conducting a study of people with schizophrenia and bipolar disorder to compare genetic changes among people with and without exposure to childhood trauma.

Preliminary analysis of the 230 individuals recruited into the study has shown high rates of childhood trauma in patients with schizophrenia (58%) and bipolar disorder (43%).

“We can already see from our preliminary analyses of brain imaging data that the people exposed to trauma have different patterns of brain function than those without such history, and this may be further related to genetic variation that we are yet to investigate,” Green says.

“Crucially, this research requires a further 60 patients with schizophrenia or bipolar disorder to participate.”

For more information or to volunteer to participate in this research, please contact Inika Gillis on ph: +61 2 8382 1436.

Media contact: Dan Wheelahan, UNSW Media Office, 0435 930 465, d.wheelahan@unsw.edu.au

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