Ann C. Childress, MD, Center for Psychiatry and Behavioral Medicine, Las Vegas, NV, and coauthors compared the safety and efficacy of Evekeo (a racemic formulation with a ratio of 1:1 D- and L-amphetamine [R-AMPH]) versus placebo using rating scales and performance measures designed to assess ADHD symptoms as well as behavior and productivity in the classroom.
In “The Efficacy and Safety of Evekeo, Racemic Amphetamine Sulfate, for Treatment of Attention-Deficit/Hyperactivity Disorder Symptoms: A Multicenter, Dose-Optimized, Double-Blind, Randomized, Placebo-Controlled Crossover Laboratory Classroom Study,” the authors describe the safety profile of Evekeo and treatment-emergent adverse events (TEAEs). They report significant improvement in ADHD rating scores with a single daily dose of R-AMPH, on the laboratory classroom days, beginning at 45 minutes postdose and extending through 10 hours. Scores for ADHD signs and symptoms improved among the children receiving twice daily R-AMPH during the initial dose-optimization phase of the study. TEAEs and changes in vital signs associated with R-AMPH were generally mild and not unexpected.
Evekeo (Arbor Pharmaceuticals, Atlanta, GA) received FDA approval for treatment of ADHD in patients 3 years of age or older in September 2014.
About the Journal
Journal of Child and Adolescent Psychopharmacology is an authoritative peer-reviewed journal published ten times per year online with Open Access options and in print. The Journal is dedicated to child and adolescent psychiatry and behavioral pediatrics, covering clinical and biological aspects of child and adolescent psychopharmacology and developmental neurobiology. Complete tables of content and a sample issue may be viewed on the Journal of Child and Adolescent Psychopharmacology website.
About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Cyberpsychology, Behavior, and Social Networking, Games for Health Journal, and Violence and Gender. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.