06:27pm Wednesday 20 September 2017

Pterostilbene, a molecule similar to resveratrol, as a potential treatment for obesity

The Nutrition and Obesity research group
The Nutrition and Obesity research group

Pterostilbene is a phenolic compound in the same family as resveratrol and is present in small amounts in a large variety of foods and beverages like blueberries or red wine. In collaboration with the United States Department of Agriculture (USDA), researchers in the UPV/EHU’s ‘Nutrition and Obesity’ Group, which belongs to the Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn) of the Carlos III Institute of Health, have observed in animal models that its administration reduces the build-up of body fat, which could reduce the risk of developing other diseases like diabetes.

Obesity is a chronic disease caused by a whole range of factors and defined as an excessive accumulation of body fat. It is a metabolic disease very prevalent in developed countries and a significant risk factor for developing certain pathologies and alterations like insulin resistance, diabetes, fatty liver, alterations in plasma lipids and hypertension, among others.

The traditional guidelines for preventing and treating obesity include following a low-calorie diet and doing moderate physical activity over the long term. However, the effectiveness of these strategies is limited and the success achieved is not always the desired one. In this context, including functional ingredients in the diet opens up new treatment perspectives. An example of these ingredients are phenolic compounds, one of which is pterostilbene.

Pterostilbene is present in small amounts in a whole range of foods and beverages like grapes, blueberries, peanuts and red wine and widely consumed by humans. Right now there are few studies analysing the effects of this molecule and they mainly focus on cancer. The study conducted in this research is the first pre-clinical piece of work that analyses the effects of this phenolic compound on obesity in the animal model. In this model, pterostilbene cuts body fat due to a reduction in fat synthesis in adipose tissue and an increase in its oxidation in the liver.

These promising results, which have resulted in a patent, could be the starting point for conducting future studies on intervention in humans and designed to confirm this anti-obesity effect.

Additional information
The ‘Nutrition and Obesity’ group has been recognised as a research group in the Basque university system by the Government of the Basque Autonomous Community (region) and belongs to the Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (CIBERobn). It conducts its activity in the Nutrition and Bromatology Departments of the UPV/EHU’s Pharmacy Faculty and at the Lascaray Ikergunea Research Centre on the Álava Campus.

Its main line of research covers obesity and its associated disorders, like dyslipemia and diabetes.  Work is also being carried out within the study of the effects of diet composition and of potential functional ingredients in the accumulation of body fat, by seeking scientific evidence and analysing the action mechanisms that justify the effects observed.

The ‘Nutrition and Obesity’ group is headed by María del Puy Portillo-Baquedano. Among its teaching research staff the group has Itziar Churruca-Ortega, Alfredo Fernández-Quintela, Arrate Lasa-Elgezua, María Teresa Macarulla-Arenaza, Jonatan Miranda-Gómez, Víctor Manuel Rodríguez-Rivera and Edurne Simón-Magro. The following people are involved as researchers: Leixuri Aguirre-López, Saioa Gómez-Zorita, Noemí Arias-Rueda, Ana Gracia-Jadraque, Itziar Eseberri-Barace, Idoia Larretxi-Lamelas, Andrea Mosqueda and Iñaki Milton.

Bibliographical Reference
Gómez-Zorita S, Fernández-Quintela A, Lasa A, Aguirre L, Rimando AM, Portillo MP.  Pterostilbene, a dimethyl-ether derivative of resveratrol, reduces fat accumulation in rats fed an obesogenic diet. Journal of the Agricultural and Food Chemistry, 2014, 62(33), pp 8371-8378.

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COMMUNICATION OFFICE
University of the Basque Country

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