10:11am Sunday 20 August 2017

Mom's obesity linked to full-term infant death

And it’s not necessarily the usual complications of pregnancy associated with being overweight—preeclampsia and gestational diabetes—that are to blame, said Dr. Eduardo Villamor, U-M associate professor of epidemiology and study co-author.

“The risk increase was more apparent among babies born at term and who died of asphyxia, congenital anomalies or sudden infant death syndrome,” he said.

The research showed that 81 percent of infants who made it to term died of these conditions or from infection.

The study of 1.85 million live single births in Sweden from 1992 to 2010 analyzed data from the Swedish Medical Birth Register, which since 1973 has collected information on about 98 percent of all births in that country.

The researchers used body-mass index definitions of underweight (less than or equal to 18.4), normal (18.5-24.9), overweight (25.0-29.9), obese grade I (30.0-34.9), obese grade II (35.0-39.9) or obese grade III (greater than 40.0) to categorize the mother’s weight at pregnancy. They found that 24 percent of women were overweight and 9 percent were considered obese.

The researchers classified the births as very preterm (22 to 31 weeks), moderately preterm (32 to 36 weeks) and term births (37 weeks and up).

Out of this population, there were 5,428 infant deaths—11 percent attributed to maternal overweight and obesity.

For those women with a normal BMI, the number of deaths was 2.4 per 1,000 infants. For women considered severely obese (grade III) the death rate was 5.8 per 1,000. Infant mortality rates also increased somewhat for overweight and moderately obese mothers.

In previous research, Villamor and the others found that maternal obesity was also associated with obstetric complications and preterm birth. In this study, they sought to investigate the association with infant deaths.

In doing so, they found that the link between maternal BMI and infant mortality was primarily confined to term births. There were some increased risks in the neonatal period among women classified as overweight or obese. Infant mortality risk for very and moderately preterm births was only increased when mom was classified as obese grades II and III.

“Maternal obesity kills babies,” Villamor said. “Preventing obesity in women may reduce risk of infant mortality. Weight loss before pregnancy among obese women might reduce the risk of infant death but this is still under investigation.”

Researchers from the Karolinska Institutet were Stefan Johansson, consultant neonatologist; Maria Altman, postdoctoral researcher; Anna-Karin Edstedt Bonamy, pediatrician; Fredrik Granath, associate professor of medical statistics; and Sven Cnattingius, professor of reproductive epidemiology.


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