5 Best CoQ10 Supplements of 2022: Top Picks from A Dietitian

Karla Tafra

Updated on - Written by
Medically reviewed by Kathy Shattler, MS, RDN

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Transparent Labs CoQ10

Transparent Labs CoQ10

  • High-potency
  • Only one ingredient
  • 60-Day money back guarantee
  • Veggie capsule

Life Extension Super-Absorbable CoQ10 (Ubiquinone) with d-Limonene

Life Extension Super-Absorbable CoQ10 (Ubiquinone) with d-Limonene

  • Super-absorbable
  • Contains D-Limonene that promotes the stability of CoQ10 in your body
  • No genetically-modified organisms (GMOs) or gluten, sugar-free

Mary's Ruth CoQ10 Gummies

Mary’s Ruth CoQ10 Gummies

  • Formula safe for kids
  • Vegan, gluten-free, non-GMO
  • Based on pectin

Dietary supplements have risen in popularity over the years with dietitians and nutritionists recommending them in almost every meal plan and nutrition program.

From multivitamins and combinations of minerals to fitness-related pre-workouts and post-workouts, there seems to be a supplement for every function in your body.

Some seem to be great for your heart and cardiovascular system, some promote your fertility and reproductive health, and others bring various benefits toward increasing your energy levels and mood. 

Even though all dietary supplements and micronutrients bring on some specific health benefits to the table, it’s always best to check your levels to know if you’re deficient and whether or not taking the said supplement is absolutely necessary in your case.

However, always check with your healthcare provider or doctor before starting any new dietary supplement, especially if you’re undergoing a specific medical treatment or taking prescription medication.

General guidelines might benefit you most, but it’s always best to assess your health situation and know exactly how much of the specific vitamin or mineral you need to thrive and function at your best.

Best CoQ10 Supplements in (December. 2022)

What is CoQ10?

CoQ10, also known as coenzyme Q10, ubiquinol, and ubiquinone, is one of the most powerful[1] antioxidants naturally produced in the human body. It’s responsible for protecting your heart, brain, and muscles, and it’s involved in a variety of biochemical reactions as well as the production of cellular energy in the mitochondria. 

As humans age, the levels of coenzyme Q10 decrease, and it’s important to maintain its levels at their optimal level for as long as possible. CoQ10 has been used as an anti-aging supplement, significantly reducing wrinkles[2], but there is not enough human research to declare it as an anti-aging treatment.

Additionally, as an antioxidant, it has a strong anti-inflammatory effect, fighting off free radicals and their oxidative damage. This way, CoQ10 supports the health of your nervous and immune system, promotes cardiovascular health, improves physical performance, and protects you from a variety of different diseases, infections, stress-related disorders, and chronic inflammation. 

CoQ10 is found in every cell in your body, but it’s mostly[3] concentrated in organs and tissues that require the most energy production, such as your heart, liver, brain, kidneys, and lungs. It’s therefore important for their optimal function as well as the function of your reproductive[4] system, supporting fertility and healthy pregnancy. 

As you age, you naturally start to lose adequate amounts of CoQ10, as we just mentioned. Fortunately, you can replenish your levels through specific high-CoQ10-containing foods and dietary supplements. Most people can get enough of CoQ10 through a balanced diet, but some people might need supplements due to a certain health condition causing impaired absorption. 

 Foods[3] that are high in CoQ10 include

  • Eggs (whole, egg whites, and egg yolk)
  • Nuts
  • Oily fish (salmon, tuna, sardines, mackerel)
  • Organ meats
  • Chicken
  • Whole grains

Having optimal levels of CoQ10 in your system is important for your overall health and longevity, and deficiencies[5] have been linked[6] to heart disease, diabetes, obesity, and even cancer. Some of the main reasons[7] for CoQ10 deficiencies include

  • Genetic mutations and defects
  • Side effects of statin medications
  • Oxidative stress caused by aging
  • Mitochondrial diseases 
  • Other nutritional deficiencies such as vitamin B6 deficiency
  • Diseases that cause an increase in demand for CoQ10 in your tissues

In order to prevent deficiencies caused by aging, medications, and other factors; it’s important to focus on quality supplements and your nutrition.

Who Should Not Take CoQ10 

Even though they’re generally considered safe, there are some people who should abstain from taking CoQ10 supplements. You should not take this supplement if pregnant, breastfeeding, or under age 18. Use with caution[8] if you have diabetes, liver failure, kidney disease, or heart failure without the consent of a physician.

How Do CoQ10 Supplements Work?

CoQ10 supplements help replenish your nutrient stores and keep them at the optimal level, preventing deficiency and promoting optimal cardiovascular function as well as necessary energy production in your cells. Adequate CoQ10 levels also help support heart health, reduce blood pressure, reduce fatigue, lower blood sugar and promote healthy cholesterol levels.

They could also be beneficial[9] for preventing congestive heart failure and helping treat migraines. CoQ10 supplements come in various forms, and you can find them as pills, chewable tablets, wafers, syrups, or an intravenous (IV) solution. 

The Line Up At A Glance

Transparent Labs CoQ10

Editor’s Choice

Transparent Labs CoQ10

  • High-potency
  • Only one ingredient
  • 60-Day money back guarantee
  • Veggie capsule

Life Extension Super-Absorbable CoQ10 (Ubiquinone) with d-Limonene

Best Absorbing

Life Extension Super-Absorbable CoQ10 (Ubiquinone) with d-Limonene

  • Super-absorbable
  • Contains D-Limonene that promotes the stability of CoQ10 in your body
  • No genetically-modified organisms (GMOs) or gluten, sugar-free

Mary's Ruth CoQ10 Gummies

Best Gummies

Mary Ruth’s CoQ10 Gummies

  • Formula safe for kids
  • Vegan, gluten-free, non-GMO
  • Based on pectin

Live Conscious CoQWell

Best For Immune Support

Live Conscious CoQWell

  • High-absorbing and dairy-free
  • Contains vitamins A and E
  • Third-party tested

Puritan's Pride Q-SORB Co Q-10 200 mg

Highest Dose

Puritan’s Pride Q-SORB Co Q-10 200 mg

  • One serving contains 200 mg of naturally fermented CoQ10
  • Rapid-release soft gel
  • Highly-absorbable formula

Best CoQ10 Supplement To Buy In 2022

Transparent Labs CoQ10

Transparent Labs CoQ10 is a high-quality CoQ10 supplement to help improve your heart health and increase energy production.

  • High-potency
  • Only one ingredient
  • 60-Day money back guarantee
  • Vegetarian capsule
  • Does not ship to all countries worldwide

Transparent Labs CoQ10 supplement supplies you with 100 milligrams (mg) of CoQ10 per serving and helps promote your heart health and an increase in energy production. It’s a clean product with only one ingredient that comes packaged in a vegetable-based capsule, making it suitable for vegans and vegetarians. 

Made with high-quality and high-potency CoQ10, it’s designed to help reduce[10] your fatigue after exercise and other forms of physical exhaustion, relieve fibromyalgia symptoms[11], lower[12] blood pressure, improve sperm[13] quality, and minimize oxidation[14] caused by physical activity. 

Since it contains no other ingredients, this product is labeled gluten-free, sugar-free, and made without any artificial colorings, fillers, thickeners, or genetically modified organisms (GMOs).

Life Extension Super-Absorbable CoQ10 (Ubiquinone) with D-Limonene

Life Extension Super-Absorbable CoQ10 (Ubiquinone) with D-Limonene is one of the best CoQ10 supplements that provides superior absorption compared to other brands on the market.

  • Super-absorbable
  • Contains D-Limonene that promotes the stability of CoQ10 in your body
  • Non-GMOs
  • Gluten and sugar-free
  • Contains gelatin, and it’s therefore not suitable for vegans and vegetarians

Life Extension Super-Absorbable CoQ10 (Ubiquinone) with D-Limonene provides 100 mg of high-quality CoQ10 per serving and comes with D-Limonene that helps stabilize it in your body, so you don’t become depleted too fast. It’s highly absorbable, supports cardiovascular health, provides antioxidant support, improves cellular energy production, and promotes brain, kidney, and heart health. 

It comes in soft gels containing gelatin, so it’s not suitable for vegans and vegetarians. Loyal customers report noticeably feeling better after only a short time taking it, and they applaud the size of the soft gel, reporting it’s easy to swallow and convenient to take.

Mary Ruth’s CoQ10 Gummies

Mary Ruth’s CoQ10 Gummies are a delicious, high-quality, vegan CoQ10 supplement for adults and kids.

  • Formula safe for kids
  • Vegan, gluten-free, non-GMO
  • Based on pectin
  • Free of most allergens
  • Contains cane sugar and tapioca syrup

Mary Ruth’s CoQ10 Gummies are one of the rare CoQ10 supplements with a vegan formula that’s suitable for those who don’t eat animal products. It’s based on pectin and has a delicious raspberry flavor, making this supplement convenient and easy to take daily. 

One gummy provides 60 milligrams (mg) of CoQ10 and helps promote heart health, cellular energy production, brain health, cognitive function, healthy aging, and cellular growth. It’s important to note that this product contains sugar, other sweeteners, and some ingredients you might be sensitive to.

Live Conscious CoQWell

Live Conscious CoQWell has a powerful and high-absorbing CoQ10 formula containing vitamins A and E for better immune health and overall wellbeing.

  • High-absorbing and dairy-free
  • Contains vitamins A and E
  • Third-party tested

Live Conscious CoQWell supplement has a highly absorbable fat-soluble CoQ10 formula that helps promote cardiovascular health and increase cellular energy production. The added vitamins A and E strengthen the antioxidant defense, preventing free radicals from causing oxidative damage to your cells. 

This product comes in the form of soft gels that raving customers report is easy to swallow and add to their daily routine. They also report feeling better after around a week of taking it, but it has to be taken with food. 

Live Conscious CoQWell is manufactured in the USA, following the manufacturing process standards set by Current Good Manufacturing Practices (cGMP). It’s also third-party tested to ensure quality, potency, purity, and an absence of harsh chemicals, heavy metals, toxins, mold, and pesticides. 

Puritan’s Pride Q-SORB Co Q-10 200 mg

Puritan’s Pride Q-SORB Co Q-10 200 mg is a high dose formula of CoQ10 that provides optimal antioxidant support and supplies your body with cellular energy.

  • One serving contains 200 mg of naturally fermented CoQ10
  • Rapid-release soft gel
  • Highly-absorbable formula
  • Contains soy and gelatin

Puritan’s Pride Q-SORB Co Q-10 200 mg comes in a rapid-release soft gel that contains 200 mg of naturally fermented CoQ10. It’s also highly purified, making it one of the better CoQ10 supplements on the market that’s more bioavailable and easier to absorb. 

Taking one soft gel a day helps promote your heart health and blood pressure, increases energy production in your cells, protects your nervous and immune system, and promotes oral and gum health that’s linked[16]to good overall cardiovascular health. The soft gel does contain soy and gelatin, making it unsuitable for vegans, vegetarians, and those hypersensitive or allergic to soy. 

Why You Should Add CoQ10 To Your Diet

Coenzyme Q10 is an important antioxidant and a key factor in cellular energy production  naturally made by our bodies, but its production drastically declines with age. Studies[17] show that CoQ10 levels peak in our 20ies and decrease up to 50% by the time we are 80. Many vitamin tablets do not contain coenzyme Q10 or don’t contain enough to replete depleted levels.

Unfortunately, most people don’t get enough of CoQ10 through their diet, leading to deficiency. Additionally, other factors can contribute to a rapid deficiency, such as taking statins and other medications. Statins alone[18] can decrease CoQ10 levels in your plasma by up to 51% in just 30 days of use. Ubiquinone supplement pills may be the only way to regain those levels.

If taking supplements isn’t easy for you, start by increasing your intake of foods containing CoQ10, such as oily fish, nuts, eggs, chicken, and organ meats. If you’re vegan or vegetarian, you’ll probably have to resort to CoQ10 supplements, as most foods containing high levels of this nutrient are from animal sources. The best non-animal sources are peanuts, soybeans, cauliflower, spinach, and broccoli. 

CoQ10 is crucial for cellular energy production, and when you have lower than optimal levels, your heart and other organs with high-energy requirements cannot function properly. Highly purified, high-quality, and highly-absorbable CoQ10 formulas help keep those levels up and prevent heart failure or other cardiovascular diseases, including improving blood pressure as well as supporting your overall health through antioxidant effects.

When Should CoQ10 Be Taken?

CoQ10 is fat soluble, so it’s best taken with meals, especially fatty foods. Some people report[19] having trouble falling asleep if taken too close to bedtime, so it’s better to take it in the morning or afternoon. 

When it comes to dosage, the typical recommendation is 90-200[5] mg per day, but research shows how even extremely high doses such as 1,200[20] mg per day are mostly well tolerated. 

What to Consider When Buying a CoQ10 Supplement

In order to choose the best within a plethora of CoQ10 supplements on the market, there are some important factors to consider:

  • Quality – as with all dietary supplements, it’s always important to ensure high-quality from a trusted source. The higher the quality of ingredients, the better the absorption and bioavailability. 
  • Third-party tested – this ensures high potency, purity, and an absence of chemicals, heavy metals, mold, and pesticides. 
  • Suitable for vegans – if you’re following a vegan or vegetarian diet, choosing a CoQ10 supplement that doesn’t contain gelatin and is dairy-free is important. There aren’t many CoQ10 supplements out there that are suitable for vegans in soft gel form, so try looking for tablets, capsules, or gummies. 
  • Pharmaceutical grade – if you’re on specific medication or drug therapy, and need extremely pure dietary supplements, look for pharmaceutical grade labels.
  • Additional micronutrients – some brands contain additional, highest-quality vitamins and minerals in their CoQ10 formula, supplying you with more important nutrients to promote better health and wellbeing. Some micronutrients and plant compounds can even help improve the absorption of CoQ10 and promote its long-lasting effects on your body. One of these is vitamin C.
  • Clean ingredients – whether the formula contains only one or a variety of ingredients, the best CoQ10 supplements are gluten-free, sugar-free, and free of GMOs, as well as any artificial fillers colorings, thickeners, additives, or sweeteners. 
  • Medications that you may be taking may interact. Coenzyme Q10 is contraindicated in conjunction with insulin, glyburide, atorvastatin, warfarin, chemotherapy, or fluvastatin. Consult your physician before starting this supplement if on medication.  

Final Thought

Coenzyme Q10 is one of the most important antioxidants in the human body, supplying all cells with the energy needed to function properly. Our cells use the energy to transport oxygen and other important nutrients to all muscles and organs, promoting their health and optimal function. This is especially important regarding heart health, brain support, immune health, and reproductive function.

Over time, our bodies start producing less and less CoQ10, depleting our cells of energy and making our bodies struggle to perform in the best way possible. Increasing your intake of foods containing high levels of CoQ10 and taking high-quality supplements to help keep optimal levels of this important antioxidant in your body and prevent potentially serious health conditions like heart failure, cognitive decline, and inflammation caused by harmful oxidation of free radicals.

Frequently Asked Questions

Do CoQ10 supplements work?

Yes, many studies show their potential benefits and success in maintaining optimal levels of CoQ10 in the body. Many people don’t take in enough food or nutrition, so supplementing is crucial to maintain optimal levels.

Are CoQ10 supplements safe?

Generally, CoQ10 supplements are safe, but they can interfere with specific medications, so it’s always best to consult with your doctor before starting a new supplement. Extremely high doses of 1000mg have resulted in some side effects[21] in those who are sensitive to CoQ10. These include diarrhea, headaches, skin rashes, and nausea.

What is the best dose for CoQ10 supplements?

The recommended dose for CoQ10 supplements is between 90 and 200 mg per day, but the best dose for you might depend on various factors, from your age and diet to your health status and whether or not you’re taking any medications.

How to take CoQ10 supplements?

Coenzyme Q10 supplements should be taken in the morning or afternoon with a meal containing at least one fatty food.

Which CoQ10 is the most effective?

CoQ10 is known under two main forms, ubiquinone and ubiquinol. The former is the oxidized form of CoQ10, and the latter is the reduced form of CoQ10. Some research[22] suggests that ubiquinol is more[23] bioavailable and therefore absorbable, but a study[24] from 2020 showed no significant difference in bioavailability between the two forms of CoQ10.

What’s the best CoQ10 supplement for fertility?

As ovaries and sperm need the energy to function properly, any type of dietary supplement containing CoQ10 that will increase cellular energy production will promote[4] fertility and reproductive health. 

How much CoQ10 should be taken daily?

Standard daily doses[25] range from 50 mg to 200 mg, depending on the patient’s age, health, and condition. The most common supplemental range is 90-200 mg. Dividing the dose into two or three times per day will reduce the likelihood of any side effects.


+ 25 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

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Karla Tafra

Medically reviewed by:

Kathy Shattler

Karla is a published author, speaker, certified nutritionist, and yoga teacher, and she's passionate when writing about nutrition, health, fitness, and overall wellness topics. Her work has been featured on popular sites like Healthline, Psychology.com, Well and Good, Women's Health, Mindbodygreen, Medium, Yoga Journal, Lifesavvy, and Bodybuilding.com. In addition to writing about these topics, she also teaches yoga classes, offers nutrition coaching, organizes wellness seminars and workshops, creates content for various brands & provides copywriting services to companies.

Medically reviewed by:

Kathy Shattler

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