5 Best Liposomal Vitamin C For Your Immunity & Skin Health 2024

Lindsey Desoto

Updated on - Written by
Medically reviewed by Melissa Mitri, MS, RD

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Pique Daily Radiance Elderberry Liposomal Vitamin C

Pique Daily Radiance Elderberry Liposomal Vitamin C

  • Free of preservatives, refined sugar, and additives
  • Contains elderberry and liposomal vitamin C
  • Third-party tested

Life Extension Vitamin C 24-Hour Liposomal Hydrogel Formula

Life Extension Vitamin C 24-Hour Liposomal Hydrogel Formula

  • Gentle on the stomach
  • Utilizes two technologies to promote better absorption
  • One-year money-back guarantee

Mary Ruth’s Megadose Vitamin C Liposomal

Mary Ruth’s Megadose Vitamin C Liposomal

  • Citrusy vanilla flavor
  • Affordable
  • Contains vitamins C and E

Vitamin C is a water-soluble vitamin best known for supporting and maintaining a healthy immune system. It also functions as an antioxidant and is essential for the growth and repair of tissues throughout your body.

Your body cannot make vitamin C on its own. Therefore, it must come from the foods you eat or dietary supplements. If you’re looking for a vitamin C supplement, you’ve likely come across a potentially more effective (and pricier) supplement called liposomal vitamin C.

But does it really provide more health benefits? And if so, how do you choose the best liposomal vitamin C supplement?

Read on to learn everything you need to know about liposomal vitamin C, including its benefits, side effects, and how to choose the best supplement. Furthermore, we’ll review five of the most popular and the best liposomal vitamin C products in 2024.

5 Best Liposomal Vitamin C On The Market In (February. 2024)

What Is Liposomal Vitamin C?

Liposomal vitamin C is a popular substitute for standard vitamin C tablets. Instead of delivering vitamin C in a traditional capsule, tablet, or powder form, liposomal vitamin C provides the vitamin inside small fat droplets to help your body absorb it better.[1]

How Does It Work?

Simply put, liposomal vitamin C is vitamin C encased within a liposome. Liposomes are tiny, spherical-shaped vesicles made up of one or more phospholipid bilayers, which closely mimic the structure of cell membranes. This enables vitamin C to be easily transported into the cells, where it is ready to be used as needed.

5 Best Liposomal Vitamin C To Buy In 2024

Pique Daily Radiance Elderberry Liposomal Vitamin C

Pique Daily Radiance Elderberry Liposomal Vitamin C contains a powerful antioxidant infusion of elderberries and liposomal Vitamin C in convenient stash-and-go packets.

  • Gentle on the stomach.
  • Contains elderberry and liposomal vitamin C.
  • Third-party tested.
  • Convenient stash-and-go packets.
  • Third-party lab results are not available online.
  • Pricey.

Founded in 2016, Pique is an organic tea company specializing in brewed and crystalized whole-leaf tea that comes in various blends.

Pique Daily Radiance Elderberry Liposomal Vitamin C is made with seven simple ingredients, including a potent antioxidant infusion of black European elderberries and liposomal Vitamin C.

Each packet contains 1,000 milligrams of vitamin C as sodium ascorbate, a less acidic form of vitamin C that is gentler on the stomach.

Daily Radiance also contains 1,900 milligrams of elderberry juice concentrate, which may help reduce the severity and duration[2] of the flu and common cold and combat sun damage.[3]

This vegan-friendly supplement is formulated with liposomal encapsulation technology to maximize absorption and is free of preservatives, refined sugar, and additives. Refrigeration is not required. However, it is strongly recommended for optimal freshness.

Daily radiance comes in convenient liquid packets and has a tartly sweet flavor from fresh fruit concentrates. All products undergo three layers of testing for pesticides, toxic mold, and heavy metals. However, lab reports from these tests are not publicly available.

One 28-serving carton costs $58. You can return your package for a full refund anytime within the first 30 days of purchase.

Life Extension Vitamin C 24-Hour Liposomal Hydrogel Formula

Life Extension Vitamin C 24-Hour Liposomal Hydrogel Formula combines two technologies that may increase the total amount of vitamin C absorbed and maintained in the bloodstream.

  • Gentle on the stomach.
  • Utilizes two technologies to promote better absorption.
  • One-year money-back guarantee.
  • Third-party lab reports are not publicly available online.

Life Extension is a well-known supplement company that delivers high-quality products formulated using pure ingredients.

Life Extension Vitamin C 24-Hour Liposomal Hydrogel Formula provides 350 milligrams of vitamin C per one-tablet serving. 

Vitamin C is in the form of calcium ascorbate,[4] which may benefit individuals with sensitive stomachs because it is gentler than ascorbic acid. This formulation also contains 40 milligrams of calcium, a relatively small amount.

Life Extension Liposomal Hydrogel Vitamin C is encased in a sunflower-derived lipid sphere for absorption. The vitamin C in this product is further protected by a hydrogel made from indigestible fenugreek fibers. 

Internal studies performed by Life Extension suggest the combination of these two technologies may increase the total amount of vitamin C absorbed and maintained in the bloodstream.

Life Extension utilizes third-party testing labs to confirm product potency and purity. However, lab reports are not publicly available online.

One bottle of 60 vegetarian tablets costs $22.95. All products sold by Life Extension come with a one-year money-back guarantee.

Mary Ruth’s Megadose Vitamin C Liposomal

Mary Ruth’s Megadose Vitamin C Liposomal contains the antioxidant vitamins C and E. It comes in an easy-to-consume liquid form and has a citrusy vanilla flavor.

  • Zero added sugar.
  • Citrusy vanilla flavor.
  • Affordable.
  • Contains vitamins C and E.
  • Contains ascorbic acid.
  • Third-party test results are not available online.

Mary Ruth’s Organics is a well-known supplement company that produces wholesome supplements made with high-quality ingredients.

Mary Ruth’s Megadose Vitamin C Liposomal comes in a convenient liquid form and has a citrusy vanilla flavor.

Each half-tablespoon serving contains 500 milligrams of vitamin C from ascorbic acid, which has a very high acidity and may cause digestive symptoms[4] when consumed on an empty stomach.

Each serving of this vitamin C supplement contains 70 calories, 4 grams of fat, and 22% of the Daily Value for vitamin E,[5] an essential fat-soluble vitamin with antioxidant properties.

The fat in Mary Ruth’s Megadose Vitamin C Liposomal comes from monounsaturated fat and polyunsaturated fats, which have heart-health benefits[6] such as improving cholesterol.

A third party tests all supplements sold by Mary Ruth’s Organics for quality and safety. However, the results of third-party testing are not publicly available at this time.

One 30-serving bottle costs $28.95. While refrigeration is not required, it is strongly recommended to preserve flavor and potency.

Pure Encapsulations Liposomal Vitamin C

Pure Encapsulations Liposomal Vitamin C contains 1,000 milligrams of vitamin C in a gentle formula for sensitive individuals.

  • Gentle on the stomach.
  • Vegan-friendly.
  • Free of artificial flavors, colors, and sweeteners.
  • Must be refrigerated after opening.
  • Third-party lab results are not publicly available.

Pure Encapsulations, founded in 1991, provides customers with nutritional supplements formulated from the purest ingredients and backed by science to help you achieve your ultimate wellness goals.

Pure Encapsulation Liposomal Vitamin C is a simple formula made with high-quality, vegan ingredients and includes soy-free liposomes from sunflower to promote absorption.

Each teaspoon of Pure Encapsulation Liposomal Vitamin C provides 1,000 milligrams of vitamin C as sodium ascorbate. It also includes natural citrus oils from orange and lemon. This product must be refrigerated after opening.

All raw materials used to formulate products are scientifically tested for purity and potency by independent certified laboratories. However, the company does not specify whether a third party tests the end products. Lab results are not publicly available online.

A 24-serving container costs $38.50.

1st Phorm Liposomal Vitamin C

1st Phorm Liposomal Vitamin C contains 1,000 milligrams of vitamin C and comes in an easy-to-consume liquid formula for simple daily usage.

  • Gentle on the stomach.
  • Convenient liquid formula.
  • Generous return policy.
  • Contains stevia.
  • Contains ascorbic acid.
  • Lab reports are not available online.

1st Phorm Liposomal Vitamin C contains 1,000 milligrams of vitamin C from ascorbic acid and sodium ascorbate per teaspoon serving. It also includes non-GMO liposomes from sunflower lecithin to promote absorption.

It is flavored using natural flavors and stevia, which studies[7] suggest may alter the composition of gut bacteria. However, further research is needed to determine if this alteration is beneficial or harmful. 

This liposomal vitamin C supplement should be refrigerated after opening and used within 45 days. All supplements sold by 1st Phorm are third-party tested. Lab reports are not publicly available to consumers at this time.

A 30-serving bottle costs $34.99. If you are unhappy with your product for any reason, it can be returned at any time for a 110% refund (minus shipping costs).

Benefits Of Liposomal Vitamin C

Vitamin C, in general, is important because it is a powerful antioxidant required by the body for healthy immune function. It also is needed for collagen production, the protein that plays a role in healthy skin, hair, and nails. 

But when it comes to supplements, liposomal vitamin C generally outshines traditional vitamin C supplements. This is because it is easier to absorb and is more effective at raising your blood levels of vitamin C.

One 2020 study[8] discovered that liposomal vitamin C from ascorbic acid was 1.77 times more bioavailable than non-liposomal vitamin C supplements.

Liposomal vitamin C also tends to come in forms that are less acidic and gentle on your stomach, such as sodium ascorbate and calcium ascorbate. This may be especially helpful to individuals who are sensitive to acidic foods.

Of note, even though liposomal vitamin C may be more effective at raising your blood levels of vitamin C, it still works in the same way once it reaches your tissues.

High-dose vitamin C supplements above the recommended dietary allowance are unlikely to provide any additional benefit in healthy individuals. 

However, some research[9] suggests that while supplementing with vitamin C intake may not prevent you from catching a cold, it can reduce the severity or duration of cold symptoms.

Vitamin C supplementation may also improve wound healing[10] in individuals with pressure ulcers.

Are There Any Side Effects?

In adults, the recommended dietary allowance[11] of vitamin C is 90 milligrams for males and 75 milligrams for females. Smokers may require 35 milligrams more per day than non-smokers.

The tolerable upper intake level[11] for vitamin C supplements in adults is 2,000 milligrams per day. This is the maximum dose unlikely to cause side effects.

In most healthy adults, vitamin C has low toxicity because once the body’s tissues become saturated, absorption decreases and the excess vitamin C will leave the body through urine.

However, a person who consumes too much vitamin C may experience mild side effects,[11] including:

  • Diarrhea
  • Nausea
  • Stomach cramps
  • Abdominal discomfort

Excess vitamin C also has the potential to cause increased iron absorption, often occurring in people with hereditary hemochromatosis.

How To Choose The Best Liposomal Vitamin C?

Here are a few things to remember when choosing the best vitamin C supplement for you.

Third-Party Testing

Dietary supplements, including liposomal vitamin C products, are not regulated by The Food and Drug Administration for safety and effectiveness. This makes third-party testing vital to verify a product’s purity and that its ingredients match the label claims.

Furthermore, it’s always a good idea to purchase supplements from a transparent brand that makes their third-party lab results visible to all potential consumers. 

Third-party testers do not always test for all contaminants, so it is essential to carefully read the lab report to see what was tested for.

Ingredients

When purchasing liposomal vitamin C supplements, it’s always important to read the Supplement Facts label to see what is present in the product.

Most liposomal vitamin C supplements contain very high amounts of the vitamin, which the person taking it may not be aware of. 

While vitamin C is water-soluble and has low toxicity, supplements may contain high amounts of fat-soluble vitamins A, D, E, or K, which are more likely to reach toxic levels[12] in the body when high amounts are consistently consumed.

Form And Storage Requirements

Although many liposomal vitamin C supplements come in liquid form, they are also available in powder, tablet, or capsule form. Liquid and powder supplements are ideal if you cannot, or prefer not to, swallow tablets or capsules. 

If you are frequently on the go, you may benefit from a supplement, such as Pique Daily Radiance Elderberry Liposomal Vitamin C, that comes in convenient daily packets.

Of note, many Liquid liposomal vitamin C supplements usually require refrigeration and tend to expire more quickly than other forms.

Lastly, the type of vitamin C in the product is important, especially if you have a sensitive stomach.

Ascorbic acid, commonly found in traditional vitamin C supplements, is highly acidic and more likely to cause digestive upset, especially when consumed on an empty stomach. Other forms, including calcium ascorbate and sodium ascorbate, are not as acidic and less likely to irritate your stomach.

What Are Other Ways To Get More Vitamin C?

Most people can easily increase their dietary vitamin C intake by consuming more fruits and vegetables. When we obtain vitamin C through whole food sources, we also get vitamins, minerals, and other beneficial compounds that can support our overall well-being.

The best dietary sources of vitamin C include:

  • Raw red and green peppers.
  • Citrus fruits (oranges, orange juice, and grapefruit).
  • Kiwifruit.
  • Broccoli.
  • Strawberries.
  • Brussels sprouts.
  • Grapefruit.
  • Broccoli.
  • Tomatoes and tomato juice.

Final Thought

Liposomal vitamin C is a type of vitamin C that’s better absorbed by your body than most other types. However, it comes with a higher price tag and is more difficult to find at your local drugstore.

The best way to boost your dietary intake of vitamin C is by increasing the amounts of vitamin C-rich fruits and vegetables you eat. Alternatively, you can also take vitamin C or liposomal vitamin C supplements.

If you are considering starting a vitamin C supplement, discuss it with your healthcare provider and/or registered dietitian to find out if it is the right choice.

Frequently Asked Questions

Is it safe to take liposomal vitamin C?

Similar to traditional vitamin C supplements, liposomal vitamin C is generally considered safe with a low toxicity risk. However, high doses of vitamin C exceeding 2,000 milligrams per day can cause unpleasant digestive symptoms.

Who should use liposomal vitamin C?

Anyone can take liposomal vitamin C. Those who may benefit the most include smokers, people with a confirmed deficiency, and others with an increased demand for vitamin C.

 What is the best dosage of liposomal vitamin C?

The highest daily intake that is believed to pose no health risks is 2,000 milligrams per day. It’s important not to exceed this dose without speaking to a healthcare provider.

How to take liposomal vitamin C?

Liposomal vitamin C typically comes in a liquid form, which can be taken directly or mixed into your favorite beverage. However, they can also come in tablet or capsule form. Supplements can be taken at any time of the day, with or without food.


+ 12 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Davis, J.L., Paris, H.L., Beals, J.W., Binns, S.E., Giordano, G.R., Scalzo, R.L., Schweder, M.M., Blair, E. and Bell, C. (2016). Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect against Ischemia–Reperfusion Injury. Nutrition and Metabolic Insights, [online] 9, p.NMI.S39764. doi:10.4137/nmi.s39764.
  2. Wieland, L.S., Piechotta, V., Feinberg, T., Ludeman, E., Hutton, B., Kanji, S., Seely, D. and Garritty, C. (2021). Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review. BMC Complementary Medicine and Therapies, [online] 21(1). doi:10.1186/s12906-021-03283-5.
  3. Lin, P., Hwang, E., Ngo, H.T.T., Seo, S.A. and Yi, T.-H. (2019). Sambucus nigra L. ameliorates UVB-induced photoaging and inflammatory response in human skin keratinocytes. Cytotechnology, [online] 71(5), pp.1003–1017. doi:10.1007/s10616-019-00342-1.
  4. Lee, J.-K., Jung, S.-H., Lee, S.-E., Han, J.-H., Jo, E., Park, H.-S., Heo, K.-S., Kim, D., Park, J.-S. and Myung, C.-S. (2018). Alleviation of ascorbic acid-induced gastric high acidity by calcium ascorbatein vitroandin vivo. The Korean Journal of Physiology & Pharmacology, [online] 22(1), p.35. doi:10.4196/kjpp.2018.22.1.35.
  5. Nih.gov. (2020). Office of Dietary Supplements – Vitamin E. [online] Available at: https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/#
  6. www.heart.org. (2017). Polyunsaturated Fat. [online] Available at: https://www.heart.org/en/healthy-living/healthy-eating/eat-smart/fats/polyunsaturated-fats
  7. Kasti, A., Nikolaki, M., Synodinou, K., Katsas, K., Petsis, K., Lambrinou, S., Pyrousis, I. and Triantafyllou, K. (2022). The Effects of Stevia Consumption on Gut Bacteria: Friend or Foe? Microorganisms, [online] 10(4), p.744. doi:10.3390/microorganisms10040744.
  8. Journal of Liposome Research. (2021). Evaluation and clinical comparison studies on liposomal and non-liposomal ascorbic acid (vitamin C) and their enhanced bioavailability. [online] Available at: https://www.tandfonline.com/doi/abs/10.1080/08982104.2020.1820521?journalCode=ilpr20
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  10. ‌Nada Bechara, Victoria M. Flood and Jenny E. Gunton. (2022). A Systematic Review on the Role of Vitamin C in Tissue Healing. [online] Available at: antioxidants-11-01605.pdf
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Lindsey Desoto

Medically reviewed by:

Melissa Mitri

Lindsey DeSoto is a Registered Dietitian Nutritionist based out of Coastal Mississippi. She earned her BSc in Nutrition Sciences from the University of Alabama. Lindsey has a passion for helping others live their healthiest life by translating the latest evidence-based research into easy-to-digest, approachable content.

Medically reviewed by:

Melissa Mitri

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