5 Best Mushroom Supplements for Immune System & Anxiety 2024

Karla Tafra

Updated on - Written by
Medically reviewed by Dr G. Michael DiLeo, MD

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Future Kind Vegan Clarity Mushrooms

Future Kind Vegan Clarity Mushrooms

  • Clarity-boosting complex of five organic mushrooms
  • Funding animal sanctuaries
  • Affordable

Peak Performance Top 5 Immune Support Mushroom

Peak Performance Top 5 Immune Support Mushroom

  • Powerful blend of five medicinal mushrooms
  • Third-party tested
  • Derived from organic and ecologically grown mushrooms in the United States

ONNIT Shroom Tech Sport

ONNIT Shroom Tech Sport

  • Helps improve aerobic performance
  • Vegan, gluten-free, sugar-free, no artificial ingredients
  • Scientifically-tested formula

15% Off Coupon: HEALTHCANAL15

Dietary supplements exist in all forms and dosages, from an individual vitamin or mineral to an array of different micronutrient combinations, all with the goal of improving your overall health. 

Medicinal mushrooms are powerful organisms that have only recently found their way into the supplement world. From boosting your immune system and reducing inflammation to improving brain health and relieving anxiety, these incredible foods can have strong positive effects on your well-being.

Read on to find the five best mushroom supplements on the market in 2022.

Best Mushroom Supplements for Immune System & Anxiety on the market in (April. 2024)

How Do Mushroom Supplements Work?

The best mushroom supplements ensure high quality, purity, and potency of their ingredients and with their carefully designed formulas they help support[1] your immune function, reduce and prevent further inflammation, protect[2] against free radicals, improve performance, aid recovery, and promote overall wellness. 

Some mushroom supplements contain only one medicinal mushroom while others combine a few different kinds. 

Depending on which mushroom is the main (or only) ingredient, the exact mushroom (or mushroom supplement blend) might be more powerful for treating or supporting one body function while another might be great for more general wellness or condition. 

Everything depends on your health and fitness goals and current state of health that will dictate which mushroom supplements are the best for you.

5 Best Mushroom Supplements to Buy in 2024

Future Kind Vegan Clarity Mushrooms

Future Kind Vegan Clarity Mushrooms have a powerful 4:1 mushroom blend containing a high dose of brain-boosting lion’s mane mushroom, known to improve cognition, focus, and memory, and even protect against dementia. 

  • Clarity-boosting complex of five medicinal mushrooms
  • Funds animal sanctuaries
  • Affordable
  • Only available online (although FREE expedited shipping)

Future Kind Vegan Clarity Mushrooms is a great blend of beneficial mushrooms, featuring 500 milligrams (mg) of lion’s mane mushroom that’s linked[3] to improved brain health and cognitive function. It’s actually considered to be one of the main nootropic compounds, or substances that improve cognition, memory, focus, and attention. 

Additionally, this product helps support your immune system and fight inflammation, promotes optimal energy levels and performance, as well as protects you from diseases and toxins. 

The product itself is a blend of lion’s mane, chaga, reishi, maitake, and shiitake mushrooms, all neatly packed in a vegan-friendly capsule. The price of the monthly supply is budget-friendly and becomes even cheaper if you choose to subscribe. 

Peak Performance Top 5 Immune Support Mushroom

Peak Performance Top 5 Immune Support Mushroom is a blend of five immune-boosting medicinal mushrooms for ultimate protection against inflammation and diseases. 

  • Powerful blend of five medicinal mushrooms
  • Third-party tested
  • Derived from organic and ecologically grown mushrooms in the United States
  • Only available online

Peak Performance Top 5 Immune Support Mushroom combines five powerful mushrooms and their fruiting bodies that have a strong immune-boosting and stress-reducing effect through their high levels of antioxidants and adaptogens. 

Containing the mushroom extract of turkey tail, reishi, shiitake, chaga, and maitake mushroom, this potent blend is completely vegan, soy-free, gluten-free, and made with no genetically modified organisms (GMOs). 

Their formula is third-party tested and made by following good manufacturing practices (GMP) and regulatory USA standards. The product itself is quite affordable, with 90 capsules per package, which should last you about one month. Additionally, they offer discounts when buying a bundle.

ONNIT Shroom Tech Sport

ONNIT Shroom Tech Sport

15% Off Coupon: HEALTHCANAL15

See ONNIT Reviews

ONNIT Shroom Tech Sport is an incredibly strong formula featuring five superstar ingredients designed to boost your energy, increase your performance, and improve your cardiovascular fitness.

  • Helps improve aerobic performance
  • Vegan, gluten-free, sugar-free, no artificial ingredients
  • Scientifically-tested formula
  • Expensive
  • Contains maltodextrin[4] which can cause digestive distress in some people.

ONNIT Shroom Tech Sport contains five powerful ingredients which help promote energy utilization throughout your exercise, increase muscle power and endurance, and increase VO2 max. 

VO2 max is a measure of fitness[5] that refers to how much oxygen your body can absorb and utilize during exercise. The higher the number, the better your cardiovascular fitness. This value can easily drop when your fitness is impaired, so keeping it high should be your ultimate goal.

The formula contains many beneficial compounds such as ashwagandha, green tea extract, Rhodiola, methyl B-12, and the mushroom extract of Cordyceps sinensis

Cordyceps is known to improve your absorption and utilization of oxygen during exercise[6] as well as help your body increase its production of adenosine triphosphate (ATP), a molecule that is crucial for delivering energy to the muscles and other parts of your body. 

This product is rigorously tested for purity and potency and it’s vegan, gluten-free, sugar-free, non-GMO, and contains no artificial ingredients. It does, however, contain maltodextrin which can potentially cause digestive problems. 

Mushroom Design

Mushroom Design has a revolutionary blend of potent vitamins and medicinal mushrooms that promote a healthy immune system and support it without being too overpowering. 

  • Blend of functional vitamins and organic mushrooms for immune support
  • Organically grown in the USA
  • ​​Eco-friendly and backed by science
  • Expensive
  • Only available online

Mushroom Design is one of the best mushroom supplements for your immune system as it features a blend of nine different vitamins and nine mushrooms all designed to support your immune system without overwhelming it. 

It comes with B vitamins (B1, B2, B5, B6, B9, B12), vitamin C, vitamin D3, and vitamin E which make the perfect pairing with cordyceps lion’s mane, chaga, maitake, reishi, shiitake, oyster, turkey tail, and agarikon. 

Together, they bring on a large variety of powerful compounds that protect your immune function, heart health, and cognitive health, as well as lower your cholesterol and stress levels. 

They are a great supplement with high doses of mushroom extracts, all derived from organically grown mushrooms in California, USA. The formula is free from any artificial ingredients and GMOs, gluten-free, sugar-free, vegan, and doesn’t contain any plant dyes. 

Wooden Spoon Herbs Mushroom Magic

Wooden Spoon Herbs Mushroom Magic is an amazing and potent supplement with the ultimate mushroom complex to support your immune function and nervous system health.

  • Dual-extraction process: tinctured and then simmered down
  • In the form of drops
  • Easy to blend in foods and drinks
  • On the pricier side
  • Might be hard to count out 60 drops per serving

Wooden Spoon Herbs Mushroom Magic contains a robust mushroom wellness formula featuring lion’s mane, shiitake, maitake, reishi, chaga, and cordyceps. Together, these mushroom extracts form a strong immune-boosting formula that improves cognitive function and nourishes your nervous system. 

It’s one of the best reishi mushroom supplements as it contains high levels of this medicinal, immune-boosting compound. The product is dissolved in alcohol to create a tincture, and it’s therefore really easy to add to any meal or drink. 

The exact 60 drops per serving might be hard to count every time, so it might not be for those with no patience. 

How To Choose The Best Mushroom Brands

The best mushroom supplements need to contain a few important features in order to really stand out from the rest on the market. 

Quality Of Ingredients

As always, the quality of ingredients comes first. If the mushrooms you’re taking the extracts from are from sketchy and unreliable sources, you’ll never be sure of their potency and purity–or safety! 

Always make sure that the brand you’re looking to buy has complete transparency around their ingredients and check for any third-party tested labels. Additionally, if the product has other ingredients next to the mushrooms, analyze their quality, too. 

Potency And Purity Of Ingredients

Hand-in-hand with high quality comes potency and purity. It’s about making sure the said formula really does contain the levels of vitamins, minerals, antioxidants, and other compounds stated on the bottle. 

Only by making sure, your ingredients are exactly what they say, can you experience the health benefits you expect. Right next to your mushrooms, ensure the entire formula is pure and free of any artificial additives, fillers, thickening agents, and colorants that exist to lower the cost and with it, the quality. 

Health Needs

Depending on your goals and needs, you might need to be smarter with your choices. If you’re looking for strong immune support, you might look for the best turkey tail mushroom supplement[7] or the one containing high doses of reishi mushrooms. 

On the other hand, if you’re looking to improve your athletic performance, you might be looking for a supplement that contains cordyceps. 

Every person is different and while some might need general guidance and everyday immune support, others might need to tackle specific health conditions and should talk with their healthcare provider and figure out if the medicinal mushroom (or blend) is the right choice for them. 

Other Ingredients

Some mushroom supplements may contain additional ingredients and micronutrients that only make the formula more potent and help you replenish much-needed vitamins, minerals, and other plant compounds you might be lacking. 

If you’re looking for a one-stop shop, you might need to find a brand that provides all you need in the micronutrient department. 

Supplement Form

Some people like capsules, others prefer tinctures, and then there are those who like mushroom powder and find it to be the easiest form to add to their daily smoothies, broths, and coffee. Find a high-quality brand in the form you prefer and start using it on a regular basis. 

Benefits Of Mushroom Supplements

The health benefits of mushroom supplements are vast, but they’re mostly concerning immune support. Every medicinal mushroom has a strong effect on supporting your immune cells and helping them become stronger in their fight against disease, toxins, and free radicals, all trying to inflict damage and cause illness. 

Most of these mushrooms improve[8] heart health, boost energy and performance, reduce stress levels, lower blood sugar[9] and cholesterol, improve cognitive function, and could potentially fight fatigue[10] and depression. 

Some of them, like turkey tail and reishi, have unique and beneficial compounds like polysaccharo peptides that have been shown to not only fight inflammation and infections but also aid in cancer[11] treatment. 

Potential Side Effects

Every supplement can have a potential side effect, even if the reviews are mostly positive. Every person is different and can have a different reaction to the dosage of mushrooms, the combination of specific mushrooms, or even to the capsule and other ingredients added to the product. The problem also occurs with dosage as it may differ drastically from one brand to another.

Most side effects of taking reishi are mild and usually feature digestive distress or nausea and vomiting. There have been some cases[12] with more severe liver problems, but they are rare. If you stick to the recommended dosage, it’s unlikely that you’ll experience any side effects. 

Chaga mushroom is generally tolerated well but can be harmful[13] if used in combination with some medication, more specifically, those for blood clotting. Chaga contains a protein that interferes with blood clotting so it’s important to consult with your doctor before any major procedures or surgery. 

Turkey tail and cordyceps are also considered safe and no studies have found any severe effects on human health. Taking too much may invoke heartburn, constipation, nausea, and digestive distress[14], especially if you’re sensitive to it or have allergic reactions. 

Shiitake mushroom is one of the most popular mushrooms in Asian cuisine and can often be found on menus and in grocery stores all over the world. The fruiting bodies of this mushroom are usually found as extracts in dietary supplements. 

They contain[15] beta-glucans, naturally occurring polysaccharides, and if eaten raw[16], they can cause dermatitis and other skin issues. There are no studies that confirm their harmful side effects in supplement form. 

Dosage

The dosage in mushroom supplements varies from brand to brand and product to product. And while some glorify one mushroom, even in a blend, others like to stick to equal doses for every ingredient. 

Reishi has usually featured around 50mg, and Chaga as well. Cordyceps is known to be dosed over one gram and lion’s mane up to 500 mg. The dosage depends heavily on the goal and function of the supplement itself. 

If the goal is general immune health support, you’ll probably encounter around 50mg of each mushroom in the blend. If the goal is improving clarity, focus, and cognitive function, the lion’s mane will take the lead; and if the goal is improved oxygen absorption during exercise, the product will contain higher levels of cordyceps.  

Final Thought

Mushroom supplements can provide a variety of beneficial compounds for optimal health and well-being. 

From immune support and cognitive health to reducing inflammation and eliminating brain fog, the mushroom-fruiting bodies found as ingredients in many wellness supplements can be a powerful health-boosting addition to your everyday diet. 

As always, consult with your doctor before starting a new supplement and ensure it’s the best option to support your health. 

Frequently Asked Questions

Which mushroom supplements are the best?

The best mushroom supplements are the ones that best fit your health needs and goals. Every person is different and, depending on their health condition, they might need different mushrooms than someone who is only looking for general wellness optimization.

What is the healthiest medicinal mushroom?

There is no healthiest medicinal mushroom. They are all healthy in their way and provide support for a variety of body functions.

Which mushroom is best for inflammation?

All mushrooms help reduce inflammation and free radical damage.

Are mushroom capsules good for you?

Yes, mushroom capsules are good for you, especially if they’re vegan, which makes them easier on your stomach. 


+ 16 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

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Karla Tafra

Medically reviewed by:

Michael DiLeo

Karla is a published author, speaker, certified nutritionist, and yoga teacher, and she's passionate when writing about nutrition, health, fitness, and overall wellness topics. Her work has been featured on popular sites like Healthline, Psychology.com, Well and Good, Women's Health, Mindbodygreen, Medium, Yoga Journal, Lifesavvy, and Bodybuilding.com. In addition to writing about these topics, she also teaches yoga classes, offers nutrition coaching, organizes wellness seminars and workshops, creates content for various brands & provides copywriting services to companies.

Medically reviewed by:

Michael DiLeo

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