Fact checkedFact Checked

This article is reviewed by a team of registered dietitians and medical doctors with extensive, practical clinical and public health experience.

5 Best NAD+ Supplements for Longevity 2023: Top Brand Reviews

Mitchelle Morgan

Updated on - Written by
Medically reviewed by Kimberly Langdon, MD

All articles are produced independently. When you click our links for purchasing products, we earn an affiliate commission. Learn more about how we earn revenue by reading our advertise disclaimer.

Wonderfeel Youngr NMN

Wonderfeel Youngr NMN

  • Patented formula made in the USA
  • Strong dose backed by studies
  • Subscribe & save $15



  • Non-GMO product
  • Made in a GMP and NSF-certified facility
  • A gluten-free, vegan-friendly product

Corllia Liposomal NAD+

Corllia Liposomal NAD+

  • Ensures proper cell function
  • Comes in softgels form
  • Anti-aging effects

Aging comes with effects on body function. The more at risk, you are for different health conditions. However, you can slow down the aging process when you have high levels of NAD+ (Nicotinamide Adenine Dinucleotide).

So, you can take the best NAD+ supplement to increase the levels and enjoy the benefits. The best NAD supplement to take has no side effects and is safe for human consumption.

5 Best NAD+ Supplements For Longevity On The Market In (June. 2023)

What Is NAD+?

NAD+ is a coenzyme available in all living things and is essential for body functions like metabolism. Maintaining proper levels of NAD+ in the body is possible when you take NAD supplements.

As you take in more NAD, you can experience better cellular, cognitive, and muscle functions

Who Should Take NAD+ Supplements?

Any adult can take NAD supplements to boost NAD levels in the body. However, older adults can benefit more from the anti-aging properties of NAD.

Besides anti-aging, these supplements are also good metabolism boosters and aid in better muscle function.

5 Best NAD+ Supplements For Longevity In 2023

Wonderfeel Youngr NMN

Wonderfeel, a biosciences company spearheading NMN research, has moved that longevity needle forward with their first-of-its-kind patented Youngr NMN formula, which is engineered by a Harvard MD, Professor Andrew Salzman.

  • Patented formula made in the USA
  • Strong dose backed by clinical trials
  • Five-star reviews
  • Only available online

Youngr’s 900 mg dose per serving of NMN is one of the highest in the market, and it is the best bang for your buck among the top brands. The dose is backed by the latest clinical trial. This NMN product also contains ergothioneine, the active element from mushrooms, dubbed as the “longevity vitamin”, resveratrol that activates enzymes, vitamin D3, and hydroxytyrosol, a powerful antioxidant found in olive oil. These ingredients work together with NMN inside the cells and optimize cellular regeneration. Overall, Youngr’s unique formula makes it highly effective and bioavailable. 

Wonderfeel Youngr™  benefits include increased energy levels, improved skin elasticity, better sleep, a sharper mind, and boost physical performance. Therefore, Wonderfeel NMN capsules are a great aging preventative supplement option for those seeking help both internally and externally.

With an introductory offer of $73 for monthly subscribers, it’s the best value among NMN products.


GENEX NAD+ is what you need to boost NAD+ levels in the body. By taking NAD supplements, you can experience an increase in energy levels and better body function.

  • Non-GMO (genetically modified organisms) product
  • Made in a Good Manufacturing Practices (GMP) and National Sanitation Foundation (NSF)-certified facility
  • A gluten-free, vegan-friendly product
  • Third-party testing in the U.S.
  • Can cause mild headaches
  • Can lead to vomiting

GENEX NAD+ supplements come in handy for proper cellular function[1] in the body. There’s less cell breakdown as an increase in NAD+ levels ensures ample protection. This means NAD+ is an essential part of cell defense in the body.

In addition, high levels of NAD+ are good for metabolism. The body has a better chance of converting most of the food you consume to energy. This comes in handy during weight management when you want to maintain a lean body.

The formulation in each GENEX NAD+ capsule contains natural ingredients safe for human consumption. These have undergone third-party testing, and packaging takes place in a safe environment. 


One more way to boost NAD+ levels in the body is by taking VIVALIDER NAD+ supplements. This NMN-rich product converts the Nicotinamide Mononucleotide into NAD.

  • Boosts NAD+ levels
  • Anti-aging properties
  • Antioxidant properties
  • Easy to consume
  • Repairs DNA damage
  • Can cause mild nausea
  • Can cause diarrhea

Nicotinamide Mononucleotide has the capacity to covert to NAD that the body needs for proper cell function. That way, you have better energy production that keeps you going daily. NAD+ has anti-aging properties that help slow down the aging process and keep you healthy longer.

The more NAD+ you have, the better the natural communication of the mitochondria and the nucleus in each cell. Any weakness in this essential natural communication means you start to experience a decline in mitochondria[3] leading to cell aging.

Apart from increasing NAD+ levels in the body, taking Nicotinamide Mononucleotide supplements is good for DNA repair. It’s also a good way of silencing or re-encoding certain genes according to normal gene sequences. As a result, you experience more DNA repair, boosting muscle function and recovery. 

Corllia Liposomal NAD+

Liposomal NAD+ supplement is a highly absorbable product that’s in the range of the best NAD supplements to maintain proper function, ensuring your levels remain healthy with age.

  • Ensures proper cell function
  • Comes in softgels form
  • Anti-aging effects
  • Safe ingredients
  • Non-GMO, Soy-free, and free of artificial flavorings
  • Can cause nausea
  • Can cause mild itching

All cells in your body require NAD (Nicotinamide Adenine Dinucleotide) for proper function. This is also responsible for energy production and cellular health. However, with age, NAD levels start to decline hence the need to take dietary supplements.

Liposomal NAD+ supplements are highly absorbable and bioavailable. This protects NAD levels from further decline due to gastric acid. The NAD instead is delivered directly to your small intestines for fast absorption by the intestine walls.

These nicotinamide riboside supplements have a powerful formulation. Each softgel has 500 milligrams (mg) NAD+ and 250 mg TMG. This high dose is essential in maintaining proper cell function when there’s enough nicotinamide riboside. TMG (Trimethylglycine) ensures ample production of nicotinamide riboside in the body.

Some potential health benefits of nicotinamide riboside, a member of vitamin B3, include anti-aging and high energy levels. When you take the best NAD+ supplements, you start to benefit from the therapeutic capability of high NAD levels. High NAD levels guard the human body.

HPN NAD3 NAD+ Booster

HPN (High-Performance Nutrition) is the brain behind these NAD+ booster supplements. These have undergone clinical trials to prove health benefits and have undergone testing by a third party.

  • Clinically proven booster supplements
  • Third-party tested
  • Increases NAD levels
  • Anti-aging properties
  • Form of Vitamin B3
  • Can cause vomiting
  • Can cause bloating

HPN is an effective NAD booster that you can take every day. This bottle contains a 90-day supply of Nicotinamide Riboside that’s safe for human consumption.

NAD+ is a natural coenzyme that all living things have. However, as you age, the levels of NAD+ drop. Therefore, taking NAD supplements can help boost it. NAD+ is crucial to your body’s cellular function in energy production.

When you take this NAD supplement, expect anti-aging benefits as your body works to restore itself through cellular repair. NAD+ slows down age-related conditions and keeps you feeling healthier for longer. Plus, it helps that this product has no harmful ingredients and adds vitamin B3 levels[2] to your body.

How We Ranked The Best NAD+ Supplements?

All supplements listed above have undergone third-party testing to ascertain top quality. In addition, these have licensed patents and the capacity for continuous cellular defense. Always check the ingredients list to see what’s in your nicotinamide riboside (NR) supplements. 

Benefits Of NAD+ Supplements

Nicotinamide riboside is good for your health and well-being. Cells in your body need NAD+ for proper function and anti-aging effects. There are numerous potential health benefits when you take nicotinamide riboside supplements.

Better Cognitive Function

Taking nicotinamide riboside booster supplements is good for your cognitive function. It’s important to note that cognitive function[4] and brain health tend to decline with age. Things get foggy, and it’s easy to start forgetting things.

One cause of this decline is low levels of nicotinamide riboside in the body. As a result, the body has less energy, and you can even feel fatigued. It’s the work of NAD+ and mitochondria (the cellular powerhouses) to lessen metabolic stressors and convert glucose to energy.

But, when the NAD levels are low, the brain can’t convert enough glucose to energy. It’s why your brain cells have less energy for proper function[5].

When you take a NAD supplement, you can benefit the brain cells by boosting energy production. In turn, you experience better cognitive function for many more years.

Protects Brain Cells

Besides better cognitive function, nicotinamide ribose also helps with brain cell protection. The cells in your brain will age, but without good NAD levels, they won’t age well.

The good news is when you take NR supplements, you can protect brain cells. This happens because NAD+ is responsible for proper PCG-1-alpha protein production. The function of this protein is cell protection[6] against oxidative stress and poor function of the mitochondria.

Research shows that poor mitochondrial function and oxidative stress can lead to brain diseases like Parkinson’s disease[7] and Alzheimer’s[8].

One study[9] was conducted using mice with Alzheimer’s Disease. During a set duration, these mice got nicotinamide riboside to boost NAD+ levels in the brain. This increased PGC-1-alpha protein by up to 50% and NAD+ levels by up to 70%. These mice exhibited an improvement when performing tasks that required better memory skills.

 However, there’s a need for more research to show that high NAD+ levels can benefit human beings with brain disorders.

Weight Management

NAD booster supplements can come in handy when you want to ensure proper weight management. One of the health benefits[10] of nicotinamide riboside supplements is an increase in metabolism. This ensures ample energy metabolism that your body needs for proper function.

However, it’s worth noting that taking nicotinamide riboside supplements alone won’t guard against weight gain. You must work out and stick to a healthy diet. As you start to watch what you eat and drink, alcohol consumption must be minimal or cease altogether.

Research[11] suggests that the human body has low levels of NAD+ due to the aging process. As a consequence, you can experience weight gain. The body has low levels of essential vitamin B3 that it needs for crucial biological processes.

You risk certain conditions as you gain more weight due to low NAD levels. Some of these health risks include heart disease, poor eye health, and diabetes.

Heart disease[12] is among the deadliest health condition in the world. This condition tends to have a higher risk factor as people get on with the years.

As you take NAD supplements, the high doses of NAD+ help reverse[13] this aging process. There’s less aorta rigidity meaning the heart doesn’t need to exert more pressure to pump blood.

However, as much as high doses of nicotinamide riboside help increase levels of NAD, this alone isn’t the answer to weight loss[14]. Also, add a good diet and exercise to the mix.

Boost Energy Levels

It’s not surprising that as you get older, you’re less energetic. Low energy levels[15] are one of the common side-effects of aging. If you remain inactive, you risk fatigue and stiffness all over your body.

The good news is taking NAD supplements is one of the best ways to boost energy production in older adults. Low NAD+ levels in your body are because of age. Therefore, taking nicotinamide riboside supplements can help improve this situation.

Having more NAD+[16] in your body leaves you feeling energized for longer. Not only does it promote healthier aging, but NAD in a highly purified form also helps keep you energetic. That way, you have more energy to exercise and see more ATP production vital for muscle function. 

Potential Side Effects

Nicotinamide riboside is essential for proper cellular function. Since age brings on low levels of NAD+ in the body, it’s important to supplement it. NAD supplement is good for boosting NAD+ levels, and the good news is there are few side effects to worry about.

Research[17] continues to show that no problems arise after taking nr supplement. But, more research is needed to show how the response is with more participants.

Note that there are mild side effects[18] that some folks experience after taking riboside supplements. These include fatigue, nausea, indigestion, stomach upset, and headaches. 

Recommended Dosage

When you plan to take NAD supplements, ensure you follow the proper dosage. These supplements come in capsule (softgels) or tablet form for easy consumption. The best ones only contain nicotinamide riboside with no other ingredients.

However, some companies add other ingredients to make the supplement more potent. Check for a polyphenol like Pterostilbene that’s a quality antioxidant[19].

Most manufacturers recommend taking two capsules or tablets a day. But always follow the guideline on the label. Results should start showing in a few weeks. Read the NAD supplements reviews to see how others view a specific brand.

Final Thought

Nicotinamide Adenine Dinucleotide (NAD) is essential for proper cellular function. However, as you age, the NAD+ levels drop, causing different age-related issues in the body. While there are natural ways to boost NAD+, there’s also the option of taking NR supplements.

When you take the NAD supplement, you can experience more energy. There are potential health benefits of nicotinamide riboside supplements. Among the top benefits is reversing age-related conditions in the body while helping you age gracefully. 

Frequently Asked Questions

Which is the best NAD supplement?

The best NAD supplement is Peak Performance NMN + Resveratrol. This multi-award-winning NR supplement is backed by 30+ patents. As an NAD+ booster supplement, this product has more than 200 published scientific studies that back it and 2 Nobel Prizes under its belt. Clinical trials to date show no serious side effects of taking Peak Performance NMN + Resveratrol supplements.

How much NAD+ hould I take daily?

The recommendation is to take 200mg to 300mg of NAD daily. However, always check for the manufacturer’s instructions on the container’s label. While others recommend taking 2 pills per day, some require taking only 1 per 24 hours.

What is the best way to take NAD+?

Taking NAD+ in capsule (softgels) or tablet form is best. This ensures you can monitor the dosage you take each day. Plus, it’s easy to take it in this form with a glass of water.

How long does it take for NAD+ supplements to work?

Most manufacturers agree that it takes eight weeks to start noticing a change in your body. As your NAD+ levels increase, there’s better cellular function exerting inward change. Soon, you start to feel energetic and can even experience fewer health challenges.

Does NAD+ supplement consumption increase your lifespan?

High levels of NAD+ in the body are a good way to ensure good aging. The lower the levels of NAD+, the more age-related issues you can face. Therefore, taking the best NAD boosters is a great way to increase your lifespan[13].

Can NAD be taken long-term?

It’s safe to take NAD boosters since they have no adverse side effects. However, there are some mild effects that folks can experience. As you continue to take these supplements, ensure you do so for 12 weeks. Supplements are good for boosting NAD+ levels in the body, but long-term consumption[20] isn’t recommended.

+ 20 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Covarrubias, A.J., Perrone, R., Grozio, A. and Verdin, E. (2020). NAD+ metabolism and its roles in cellular processes during ageing. Nature Reviews Molecular Cell Biology, [online] 22(2), pp.119–141. doi:10.1038/s41580-020-00313-x.
  2. Radenkovic, D., Reason and Verdin, E. (2020). Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals, [online] 13(9), p.247. doi:10.3390/ph13090247.
  3. Schultz, M.B. and Sinclair, D.A. (2016). Why NAD + Declines during Aging: It’s Destroyed. Cell Metabolism, [online] 23(6), pp.965–966. doi:10.1016/j.cmet.2016.05.022.
  4. Murman, D. (2015). The Impact of Age on Cognition. Seminars in Hearing, [online] 36(03), pp.111–121. doi:10.1055/s-0035-1555115.
  5. Lautrup, S., Sinclair, D.A., Mattson, M.P. and Fang, E.F. (2019). NAD+ in Brain Aging and Neurodegenerative Disorders. Cell Metabolism, [online] 30(4), pp.630–655. doi:10.1016/j.cmet.2019.09.001.
  6. Sweeney, G. and Song, J. (2016). The association between PGC-1α and Alzheimer’s disease. Anatomy & Cell Biology, [online] 49(1), p.1. doi:10.5115/acb.2016.49.1.1.
  7. Bose, A. and Beal, M.F. (2016). Mitochondrial dysfunction in Parkinson’s disease. Journal of Neurochemistry, [online] 139, pp.216–231. doi:10.1111/jnc.13731.
  8. Chen, X., Stern, D. and Du Yan, S. (2006). Mitochondrial Dysfunction and Alzheimers Disease. Current Alzheimer Research, [online] 3(5), pp.515–520. doi:10.2174/156720506779025215.
  9. Gong, B., Pan, Y., Vempati, P., Zhao, W., Knable, L., Ho, L., Wang, J., Sastre, M., Ono, K., Sauve, A.A. and Pasinetti, G.M. (2013). Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Neurobiology of Aging, [online] 34(6), pp.1581–1588. doi:10.1016/j.neurobiolaging.2012.12.005.
  10. Martens, C.R., Denman, B.A., Mazzo, M.R., Armstrong, M.L., Reisdorph, N., McQueen, M.B., Chonchol, M. and Seals, D.R. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications, [online] 9(1). doi:10.1038/s41467-018-03421-7.
  11. Okabe, K., Yaku, K., Tobe, K. and Nakagawa, T. (2019). Implications of altered NAD metabolism in metabolic disorders. Journal of Biomedical Science, [online] 26(1). doi:10.1186/s12929-019-0527-8.
  12. CDC (2019). Know Your Risk for Heart Disease. [online] Centers for Disease Control and Prevention. Available at: https://www.cdc.gov/heartdisease/risk_factors.htm
  13. Shade, C. (2020). The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule. Integrative medicine (Encinitas, Calif.), [online] 19(1), pp.12–14. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238909/
  14. Méndez‐Lara, K.A., Rodríguez‐Millán, E., Sebastián, D., Blanco‐Soto, R., Camacho, M., Nan, M.N., Diarte‐Añazco, E.M.G., Mato, E., Lope‐Piedrafita, S., Roglans, N., Laguna, J.C., Alonso, N., Mauricio, D., Zorzano, A., Villarroya, F., Villena, J.A., Blanco‐Vaca, F. and Julve, J. (2021). Nicotinamide Protects Against Diet‐Induced Body Weight Gain, Increases Energy Expenditure, and Induces White Adipose Tissue Beiging. Molecular Nutrition & Food Research, [online] 65(11), p.2100111. doi:10.1002/mnfr.202100111.
  15. https://www.facebook.com/NIHAging (2019). Fatigue in Older Adults. [online] National Institute on Aging. Available at: https://www.nia.nih.gov/health/fatigue-older-adults
  16. Mehmel, M., Jovanović, N. and Spitz, U. (2020). Nicotinamide Riboside—The Current State of Research and Therapeutic Uses. Nutrients, [online] 12(6), p.1616. doi:10.3390/nu12061616.
  17. Airhart, S.E., Shireman, L.M., Risler, L.J., Anderson, G.D., Nagana Gowda, G.A., Raftery, D., Tian, R., Shen, D.D. and O’Brien, K.D. (2017). An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLOS ONE, [online] 12(12), p.e0186459. doi:10.1371/journal.pone.0186459.
  18. Dellinger, R.W., Santos, S.R., Morris, M., Evans, M., Alminana, D., Guarente, L. and Marcotulli, E. (2017). Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study. npj Aging and Mechanisms of Disease, [online] 3(1). doi:10.1038/s41514-017-0016-9.
  19. Li, Y.-R., Li, S. and Lin, C.-C. (2017). Effect of resveratrol and pterostilbene on aging and longevity. BioFactors, [online] 44(1), pp.69–82. doi:10.1002/biof.1400.
  20. NATIONAL INSTITUTES OF HEALTH (2020). Office of Dietary Supplements – Dietary Supplements: What You Need to Know. [online] ods.od.nih.gov. Available at: https://ods.od.nih.gov/factsheets/WYNTK-Consumer/.
Mitchelle Morgan

Medically reviewed by:

Kimberly Langdon

Mitchelle Morgan is a health and wellness writer with over 10 years of experience. She holds a Master's in Communication. Her mission is to provide readers with information that helps them live a better lifestyle. All her work is backed by scientific evidence to ensure readers get valuable and actionable content.

Medically reviewed by:

Kimberly Langdon

Harvard Health Publishing

Database from Health Information and Medical Information

Harvard Medical School
Go to source

Trusted Source

Database From Cleveland Clinic Foundation

Go to source

Trusted Source

Database From U.S. Department of Health & Human Services

Governmental Authority
Go to source


Database from World Health Organization

Go to source

Neurology Journals

American Academy of Neurology Journals

American Academy of Neurology
Go to source


United Nations Global Compact
Go to source

Trusted Source

Database From National Institute for Occupational Safety & Health

U.S. Department of Health & Human Services
Go to source

Trusted Source

Database from U.S. National Library of Medicine

U.S. Federal Government
Go to source

Trusted Source

Database From Department of Health and Human Services

Governmental Authority
Go to source

PubMed Central

Database From National Institute Of Health

U.S National Library of Medicine
Go to source

Help us rate this article

Thank you for your feedback

Keep in touch to see our improvement