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5 Best Vitamin D3 and K2 Supplements 2022


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Medically reviewed by Kimberly Langdon, MD

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Nuzena Solar Essence Vitamin D3 K2+

Nuzena Solar Essence Vitamin D3 K2+

  • Supports healthy skin.
  • Vegan supplement.
  • Free shipping above $50.

Live Conscious K2+D3

Live Conscious K2+D3

  • Non (genetically modified organism) GMO.
  • Supports bone health.
  • 100% money-back guarantee.

Onnit Vitamin D3 Spray with Vitamin K2 in MCT Oil

Onnit Vitamin D3 Spray with Vitamin K2 in MCT Oil

  • Flavored vitamin spray.
  • Plant-based formula.
  • Easy to use

The most common nutrients we often think about in terms of bone health are vitamin D, calcium, and magnesium. But these are not the only ones that help you achieve healthy bones.

An equally important nutrient for bone health is vitamin K[1], which helps significantly reduce the rate of fractures and increase bone mineral density in individuals with osteoporosis.

Here are some of the vital functions these nutrients achieve in the body:

  • Calcium is quickly assimilated and reaches bone mass thanks to vitamins D3 and K2, preventing vascular calcification[2]. Mineral deposits on the arterial walls and veins are known as vascular calcifications. The deposits can cling to fat or plaque in the arteries that have previously formed on the inside walls of blood vessels. Vascular calcification is common, but it can be dangerous if it accumulates over time—calcium steps in to help maintain the cardiac muscle tissue and bones.
  • K2 supports healthy blood[3] clotting, whereas D3 promotes a robust immune system[4] and muscle function[5].
  • Vitamin D3 guarantees that calcium is quickly metabolized in the bone. K2, also known as menaquinone-7(MK-7), stimulates the protein osteocalcin[6], which helps calcium absorb into the bone. Calcium cannot function properly without D3 and K2.
  • Vitamin K2 (MK-7) stimulates a protein called matrix GLA protein[7] (MGP) to bind excess calcium in the blood. This helps to increase the flow of calcium through the blood vessels, preventing buildup. 

Best Vitamin D3 K2 Suppplements (August. 2022)

Who Should Use Vitamin D3 and K3?

Since the primary function of this nutrient pair is to promote bone health, those with bone-related issues would benefit the most. This group may need higher doses of these key bone-supporting nutrients, including the best vitamin D3 and K2 supplements.

The next group of individuals is children with rickets[8]. Rickets is a bone disorder resulting from vitamin D deficiency.

In addition, those with secondary hyperparathyroidism[9] and bone loss resulting in osteoporotic fractures also need this vitamin D3 and K2 combo. 

Lastly, individuals with mineralization abnormalities[10] also need K2 and D3 vitamin supplements. These abnormalities make it difficult for bones and cartilage to properly develop and heal and can lead to osteomalacia and muscular weakness, increasing the rate of one falling and breaking their bones.

People with blood clotting difficulties resulting in excessive bleeding may also require vitamin K2 and vitamin D supplements to support healthy blood clotting.

Finally, people who live in places with little sun exposure may need to take vitamin D supplements to boost their vitamin D levels.

The optimal vitamin D level[11] is above 20 ng/ml (50 nmol/l).   Some specialists, however, believe that vitamin D blood levels over 30 ng/ml (75 nmol/l) are ideal.

Vitamin K levels should be between 0.2 to 3.2 ng/mL. According to the National Institutes of Health[12], for adults and children aged four and up, the Daily Value, DV, for vitamin K is 120 micrograms.

Vitamin D and K requirements vary depending on the period of life. This means children, teens, pregnant women, and breastfeeding women will have varying doses. Consult your doctor before using any vitamin D or K supplements.

This article examines five of the top D3 and K2 supplements available. Unlike other best vitamin D3 and K2 supplements reviews, we’ll focus on what makes each of these brands unique.

The Line Up At A Glance

Nuzena Solar Essence Vitamin D3 K2+

Best Vitamin D3 and K2 Tablet For Healthy Skin

Nuzena Solar Essence Vitamin D3 K2+

  • Supports healthy skin.
  • Vegan supplement.
  • Free shipping above $50.

Live Conscious K2+D3

Editor’s choice

Live Conscious K2+D3

  • Non (genetically modified organism) GMO.
  • Supports bone health.
  • 100% money-back guarantee.

Onnit Vitamin D3 Spray with Vitamin K2 in MCT Oil

Best Vitamin D3 and K2 Spray

Onnit Vitamin D3 Spray with Vitamin K2 in MCT Oil

  • Flavored vitamin spray.
  • Plant-based formula.
  • Easy to use

Mary Ruth’s Vegan Vitamin D3 + K2

Best Vitamin D3 and K2 Liquid Supplement

Mary Ruth’s Vegan Vitamin D3 + K2

  • Non-GMO
  • Ideal for kids.
  • Great customer service.

Alive By Science - Liposomal Vitamin D3 & K2

 Best Liposomal Vitamin D3 and K2 Supplement

Alive By Science – Liposomal Vitamin D3 & K2

  • Bioavailable liposomes.
  • Non-GMO.
  • vegan-friendly.

5 Best Vitamin D3 and K3 Supplements Reviews in 2022

Nuzena Solar Essence Vitamin D3+K2

Nuzena Solar is simply sunshine in a bottle. The brand claims that these veggie capsules aid healthy skin, bones, joints, and the immune system.

  • It promotes healthy skin.
  • This supplement supports the development and preservation of strong bones and joints.
  • It may help with immunity.
  • It is a non-GMO, gluten-free, and sugar-free formula.
  • It is a vegan vitamin D3 and K2 supplement.
  • There are limited client feedback sources to prove its credibility and effectiveness

The foremost benefit that Nuzena offers its clients is an added perk most advertised vegan vitamins do not provide: healthy skin!

They highlight that taking Vitamin D in supplements or including it in the diet can help reduce skin deterioration and premature skin aging because of the anti-oxidant presence in the vitamin. It may also help with certain skin[13] conditions. Vitamin D3 also has potent anti-inflammatory[14] qualities, which may help soothe burns, skin irritations, and skin damage, and reduce stretch marks.

In addition, you may also celebrate healthy bones, joints, and a boosted immunity.

The ingredients included in this supplement are vitamins D3, K2, calcium, and BioPerine.

BioPerine from black pepper[15] is an excellent addition because it is said to improve nutrient absorption in the body. It increases the bioavailability of any other vitamins you take, allowing more essential vitamins to enter your system where they can be put to good use.

Besides that, the brand claims to use organic science-backed ingredients that are gluten-free, sugar-free, and non-GMO. They offer free shipping with orders above $50, and there is a  personalized health care professional available if you have questions.

Live Conscious K2+D3

It’s the best vitamin supplement to take to increase vitamin D3 and K2 intake. It has highly bioavailable ingredients that support strong bones, a healthy immunity, and blood health: no more weakness, fatigue, or bleeding.

  • It is a non-GMO vitamin K2 and D3 supplement.
  • It is gluten-free, soy-free, and dairy-free.
  • The brand offers attractive discounts with bulk purchases.
  • It supports strong bones and healthy blood circulation.
  • It supports optimum immune system function.
  • It contains bioavailable ingredients in its formula.
  • Live Conscious offers a 100% money-back guarantee all year round
  • Not ideal for women that are trying to conceive, are pregnant, or are nursing

Peace, integrity, curiosity, and commitment are the four pillars of the Live Conscious brand. The brand is also receptive to user input and offers a 100 percent money-back guarantee to provide the best service possible to its customers.

K2+D3 is a combination of nutrients that are highly bioavailable and help grow and maintain healthy and strong bones. MenaQ7® Menaquinone-7, the vitamin K2 form, works in conjunction with vitamin D3 to help promote optimal calcium absorption and use. This can result in increased bone strength and wellness.

Organic non-GMO avocado oil, water, gelatin, and glycerin are the other ingredients in this product.

Live Conscious offers its clients free shipping in the US and extends attractive discounts to bulk orders. They also have an online Very Important Person (VIP) community where users can interact and share experiences and tips using the supplement.

Onnit Vitamin D3 Spray With Vitamin K2 In MCT Oil

Most of the best vitamin D supplements sold are in the form of tablets, capsules, and liquid vitamins but not Onnit. Onnit went a different direction and made a revolutionary vitamin D3 and K2 supplement as a spray. With this, you can get your daily dose of vitamin D and K when you’re on the go!

  • The spray is plant-based, perfect for vegans and vegetarians.
  • It is easy to use.
  • The brand offers a money-back guarantee.
  • It is a portable spray and easy to use on the go.
  • Some people are not used to having supplements as a spray, so they are skeptical about using them.
  • It is expensive.

With plant-based Vitamin D3 Spray in MCT Oil; you can improve bone, cardiovascular, and general vitality in a few sprints. This plant-based ingredient Onnit Vitamin D3 Spray, is one of the best vegan vitamin D3 and K2 supplements derived from lichens, providing  1,000 IU of vitamin D per serving.

This spray is extracted using a mechanism that accounts for heat, moisture, and light. The method ensures that the vitamin D3 present is stable, natural, and effective. 

Additionally, this spray comes with a base of clean, denatured MCT oil. This vitamin D Spray from Onnit is compact enough to carry in your pouch or backpack. So take it with you and get your daily dose of sunshine anywhere, everywhere, and whenever you need it.

The spray comes in two different flavors: passion fruit guava and grapefruit. To use, spray five times before swallowing.

Mary Ruth’s Vegan Vitamin D3+K2

Founded as a family business, this mom and daughter team developed Mary Ruth’s with numerous wellness supplements. This is a liquid vitamin D3 and K2 supplement that helps you keep your D and K vitamin blood levels in the optimum range.

  • The brand has good customer service.
  • It is a vegan liquid supplement.
  • It is a compact liquid vitamin to use on the go.
  • It is allergen-free, gluten-free, vegan, and a non-GMO supplement.
  • It supports bone and heart health.
  • It is an affordable liquid supplement.
  • Flavorless and therefore versatile.

MaryRuth Ghiyam, a chef, nutritional advisor, and wellness educator, founded MaryRuth’s. She owns and manages the business with her mum. The business is located in California.

At MaryRuth’s, they believe that the best vitamin D3 and K2 supplements for your wellness are plant-based, non-GMO, vegan ingredients that contain the fewest allergens.

They make every effort to source only the finest ingredients and design delicious products that help you keep your health and guide your body toward wellness. They also have supplements for brain function for both adults and kids. The liquid supplement contains vitamin K2 (MK-7), vitamin D3 (as Lichen), organic olive oil, and organic medium-chain triglycerides[16], otherwise known as MCT, from coconut oil. Because of this ingredient blend, this brand provides the best organic vitamin D3 and K2 supplements in the vast market for bone health, immunity, and heart health.

Alive By Science Liposomal Vitamin D3 & K2

Alive By Science has placed their supplement in a tiny, fat-like particle called a liposomal. The size is intended to speed absorption[17]; thus, this vitamin D3 and K2 supplement may exert its effects more quickly r than capsules would.

  • The liposomes increase the bioavailability of the vitamins.
  • The process of gentle manufacturing maximizes purity and potency.
  • The drops are simple to consume.
  • Vegans will enjoy it.
  • It is an ono-GMO supplement
  • The lid makes taking the drops difficult.

The liposomes envelop and shield the vitamin K2 and D3 while you consume them, allowing them to pass through your gastric acid unharmed. This increases the bioavailability of these vitamins, allowing the body to utilize them better once they get to the intestines.

The unique production method is another feature that makes this supplement stand out. u The ingredients are not exposed to heat or high pressure, and they are extensively purified and filtered.

This vitamin D3 and K2 supplement are also vegan-friendly, making it acceptable to a wide range of people with various dietary limitations.

Simply spray two drops of the vitamin into a glass of water twice a day.

Forms of Vitamin D & Vitamin K

Vitamin D and K supplements come in various forms, with some being better than others. 

Below are the different forms of each vitamin and how to determine which is best:

Vitamin K

It’s a fat-soluble vitamin found in two main forms:  K1 and K2.  There are several other kinds of vitamin K, but these are the two most commonly found in the human diet.

All forms of vitamin K have the same fundamental function. They activate proteins that help with blood clotting, bone health, and heart health.

Vitamin K1[18], also known as phylloquinone, is abundant in green-leafed veggies. It accounts for 75–90% of all vitamin K consumed by humans.

Vitamin K2 is generated by gut bacteria and can be present in fermented foods and animal products.s.

Vitamin K1 and K2 may have drastically different impacts on health depending on how and where they are absorbed in the body. 

The human body doesn’t do a good job at utilizing vitamin K1 from plants. According to one study[19], only about 10% of the K1 present in plants is absorbed.

Vitamin K2 uptake is less well understood. Researchers hypothesize that K2 is commonly found in fat-containing foods like fatty fish and in the presence of fat, may be more easily absorbed[20] than K1.

Vitamin K2’s chemical structure also permits it to circulate in the blood for a longer period of time compared to vitamin K1. Some types of vitamin K2 can persist in the bloodstream for days[21], while vitamin K1 only stays in circulation for a few hours.

Some experts believe that vitamin K2’s extended circulation time improves its utilization throughout the body’s cells. In this regard, supplements of vitamin K2 may be more efficient than K1 supplements for the long haul.

Vitamin D

The D vitamins are also fat-soluble vitamins that aid calcium absorption[22], support bone health and boost immune function[23].

Vitamin D supplements come in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol).

Vitamin D2 is obtained from natural sources[24] such as wild mushrooms and fortified foods such as dairy and cereals. Its potency is usually expressed in international units, abbreviated as “IU of vitamin D” on the packaging.

Fish oil, liver, cod liver oil, fatty fish, and egg yolks are some of the best sources of vitamin D3. Vitamin D3 is produced whenever your skin is exposed to sunshine. It is commonly referred to as the sunshine vitamin because of this. Dosages are calculated in international units as well. Vitamin D3 is accessible in all forms in pharmacies without a prescription.

In Research conducted, postmenopausal women diagnosed as vitamin D deficient were examined for effects of high intake[25] of vitamin D3 or vitamin D2 on calcifediol concentrations, the active circulating form of vitamin D. According to the findings, vitamin D3 produced around twice as much plasma calcifediol in this patient group as vitamin D2.

Vitamin D3 was also effective in creating higher amounts of 25(OH) D, or calcifediol, in a second clinical experiment[26] evaluating a 10-week biweekly 50,000 IU dose of both vitamin D3 and vitamin D2 in demographically comparable populations.

Symptoms of Vitamin D & K Deficiency

When your body doesn’t have enough vitamin D and K, here are how deficiency symptoms may show up: 

Low vitamin D signs

  • Weak and brittle bones.
  • Fatigue.
  • Muscle cramps, pain, or weakness.
  • Mood changes.

Low vitamin K signs

  • Excessive bleeding even on a small wound.
  • Blood in stool.
  • Vomiting blood.
  • Hemorrhage.

Health Benefits of Vitamin D3 and K2 Supplements

The primary benefit of combining vitamins D3 and K2 promotes a healthy bone system. Taking vitamin supplements abundant in these two vitamins is essential to especially help those with osteoporosis regain bone density and reduce the rates of bone fractures.

These same vitamins, K2[27] and D3[28], also help support other body systems like the cardiovascular system. They do this by working to keep the blood vessels clear from excess calcium buildup[29], which may increase the risk of heart disease. With enhanced calcium absorption, there is little or none left in the blood vessels to cause calcification and a potential heart disease risk.

Vitamin K has been linked to enhanced satellite cell proliferation[30] and movement in the muscle. Cell proliferation is the balance of cellular division and cell loss through cell death or specialization. It may also be involved in the metabolism of energy in the muscles. This facilitates healthy muscle function to get you through those hard workouts and especially taxing days.

Final Thought

The human body could do without the best vitamin D3 and K2 supplements if you are consistently following a  healthy diet with a variety of nutrients. And if you regularly eat healthy fats such as those in salmon, you may get your dose of vitamin D3. A busk under the warm sun may also supplement you with this nutrient.

You can avoid vitamin D insufficiency by maintaining a healthy level of vitamin D3. You’ll also be able to avoid osteomalacia[31], a severe vitamin D deficit. Brittle bones, bone pain, and muscle weakness are all symptoms of osteomalacia.

Additionally, include a meal with organ meat like liver on that same day, and you have had your supply of vitamin K2.

However, the reality is that these five best vitamin D3 and K2 supplements may be needed in certain circumstances, such as those at an older age or who have a deficiency. They help strengthen bones, teeth, skin, heart, and immunity.

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It is best to consult with a dietitian to find the supplement that fits you best in terms of dose, lifestyle, and personal preference. When you do that, you will gain the most benefit.

But remember, these are dietary supplements, not meal replacement remedies. You still need to eat right to reap the benefits!

Frequently Asked Questions

Who is at risk of D3 and K2 deficiency?

Older adults are at risk of both. Breastfeeding children are at risk of a vitamin D3 deficiency mainly because human milk is a poor source of vitamin D. The sun and supplementation are the best remedies.

Do I really need vitamin D3 and vitamin K2?

For healthy and strong bones, better immunity, and muscle function, you need vitamin D3 and K2. These two essential vitamins are abundant in natural sources but can also be provided to the human body by supplementation.

Why is it important to take vitamin D3 and K2 supplements?

It is crucial as it offers the body an extra supply of these essential vitamins that it may not be getting enough of from diet.

What if I take too much vitamin K2?

Consuming too much vitamin K2 hasn’t been linked to significant adverse effects. It is, nevertheless, prudent to adhere to the prescribed consumption and consult your doctor for personalized recommendations.

What is the reference daily intake (RDI) of vitamin D?

The Recommended Dietary Allowance for men and women aged 19 and up is 600 IU per day, and for adults aged 70 and up is 800 IU per day.

+ 31 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

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Medically reviewed by:

Mitchelle Morgan is a health and wellness writer with over 10 years of experience. She holds a Master's in Communication. Her mission is to provide readers with information that helps them live a better lifestyle. All her work is backed by scientific evidence to ensure readers get valuable and actionable content.

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