Their findings, published in the American Society of Hematology journal Blood, could have important implications for the way in which at-risk women are identified and preventative measures administered.
Epidemiologist Dr Matthew Grainge, in the University’s School of Community Health Sciences, who led the study, said: “VTE is a rare but serious complication of pregnancy and childbirth. It affects around one or two pregnancies per 1,000 but, despite this, remains a leading cause of mortality in expectant and new mothers in developed countries.
“Preventative measures for VTE, such as a daily dose of heparin, may not be cost effective or safe and are therefore only recommended for women who are considered high risk. However, there is currently inconsistency and disagreement over the factors which put women in that high-risk category and we hope that this research will provide clinicians with valuable new information.”
VTE — such as deep vein thrombosis (DVT) — are blood clots that form in a blood vessel and can be potentially life-threatening if the clot breaks off (embolises) and travels to the lung causing a blockage of the arteries of the lung known as pulmonary embolism (PE).
The study used data from GP patient records, hospital discharge forms and medications prescribed by primary healthcare professionals to study pregnancies of women aged between 15 and 44 between January 1995 and July 2009 — totalling almost 400,000 pregnancies.
Researchers identified all women who developed VTE for the first time during their pregnancy, including deep vein thrombosis (DVT), then extracted important key information about the mother from their medical records including their age, body mass index (BMI) and whether they smoked.
Calculating the risks
Co-existing medical factors including varicose veins, inflammatory bowel disease (IBD) and heart conditions such as heart disease were also taken into account.
They then used sophisticated data analysis methods to calculate the incident rate ratios to compare the risks of VTE to people without the specified risk factor.
They discovered that the risk of VTE during pregnancy was only marginally higher for women who were aged over 35 years old, had a BMI greater than 25 or who smoked. Medical complications such as pre-existing diabetes, varicose veins and IBD were all associated with greater risk, but not pre-existing high blood pressure.
Stillbirth ‘most significant risk’
Perhaps most significantly, women who suffered a still birth were six times more likely to have a VTE.
Dr Grainge added: “Our results may have important implications for the way that preventative measures for VTE are delivered in healthcare settings in developed countries. We believe the strong association between stillbirths and premature births and VTE in particular is a finding of real importance which has received only limited attention to date. They are not currently incorporated in the guidelines for risk assessment for VTE and, if they were, then many cases associated with those risk factors could potentially be prevented.”
The study, Risk Factors for First Venous Thromboembolism Around Pregnancy: A Population Based Cohort Study from the United Kingdom, was carried out as part of a PhD project on VTE prevention by Alyshah Abdul Sultan in collaboration with Professor Catherine Nelson-Piercy at the Women’s Health Academic Centre at Guy’s and St Thomas’ Foundation Trust.
A copy of the paper can be found on the web.
— Ends —
Notes to editors: The University of Nottinghamhas 42,000 students at award-winning campuses in the United Kingdom, China and Malaysia. It was ‘one of the first to embrace a truly international approach to higher education’, according to the Sunday Times University Guide 2013. It is also one of the most popular universities among graduate employers, one of the world’s greenest universities, and winner of the Times Higher Education Award for ‘Outstanding Contribution to Sustainable Development’. It is ranked in the UK’s Top 10 and the World’s Top 75 universities by the Shanghai Jiao Tong and the QS World Rankings.
More than 90 per cent of research at The University of Nottingham is of international quality, according to the most recent Research Assessment Exercise. The University aims to be recognised around the world for its signature contributions, especially in global food security, energy & sustainability, and health. The University won a Queen’s Anniversary Prize for Higher and Further Education for its research into global food security.
More information is available from Dr Matthew Grainge on +44 (0)115 823 0456, [email protected]
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