01:35pm Thursday 14 December 2017

Exclusive Breastfeeding May Be the Wisest Tactic for HIV-positive Moms in Sub-Saharan Africa

HIV-infected women in sub-Saharan Africa who fed their babies exclusively with breast milk for more than the first four months of life had the lowest risk of transmitting the virus to their babies through breast milk, according to researchers at Columbia University’s Mailman School of Public Health. Women who stopped breast feeding earlier than four months had the highest concentrations of HIV in their breast milk, and those who continued to breastfeed, but not exclusively, had concentration levels in-between the two practices. The findings are online in the journal Science Translational Medicine.

HIV-infected women typically have a 10% to 15% chance of transmitting the virus to their babies through breast milk. However, in sub-Saharan Africa where infectious diseases are rampant and where clean water  and sterile conditions for preparing formula can be hard to find and often life-threatening, breastfeeding is essentialplays a vital role in for keeping infants healthy. Breast milk contains many important components that help developing immune systems fend off infectious diseases.  

Nonetheless, because breastfeeding can transmit HIV, some health experts have suggested that weaning early could be advantageous. “Our study was designed to test this idea,” says Louise Kuhn, PhD, Mailman School professor of Epidemiology.

Dr. Kuhn and colleagues conducted a randomized clinical trial in Zambia to examine the effectiveness of early weaning to reduce HIV transmission and infant mortality.  Over 950 HIV-infected women in the study were recommended to breastfeed their babies starting at birth for at least four months. At four months, half of the women were encouraged to stop breastfeeding, while the other half were advised to continue. Breast milk was collected from all women at four and a half months. Throughout the study, infants were tested regularly for possible HIV transmission.

The researchers found the highest concentrations of HIV in the breast milk of women who stopped breastfeeding at 4 months. More than three-quarters (77%) of the women who had stopped breast feeding had detectable concentrations of HIV in their breast milk compared to 39.5% of those exclusively breastfeeding at four and a half months. The two groups of women had showed no differences two weeks earlier at four months.

Women who continued to breastfeed, but who supplemented with formula or other foods, had higher breast milk HIV concentrations than those practicing exclusive breast feeding. The results offer evidence that even subtle changes in the frequency of breastfeeding during infancy can affect concentrations of HIV in breast milk.

“Our results have profound implications for prevention of mother to-child HIV transmission programs in settings where breast-feeding is necessary to protect infant and maternal health,” wrote Dr. Kuhn, who is also affiliated with the Gertrude H. Sergievsky Center at Columbia University Medical Center. “Our data demonstrate that early and abrupt weaning carries significant risks for infants. It suggests that HIV-positive women who want to breastfeed should do so exclusively for the first six months of the baby’s life and in most cases longer, while also being adherent to anti-retroviral therapy. Weaning should be done slowly.”

Contact Us

Stephanie Berger
212-305-4372


Share on:
or:

MORE FROM Pregnancy and Childbirth

Health news