Researchers from King’s College London have for the first time used a novel form of MRI to identify crucial developmental processes in the brain that are vulnerable to the effects of premature birth. This new study, published today in the Proceedings of the National Academy of Sciences (PNAS), shows that disruption of these specific processes can have an impact on cognitive function.
The researchers say the new techniques developed here will enable them to explore how the disruption of key processes can also cause conditions such as autism, and will be used in future studies to test possible treatments to prevent brain damage.
Scientists from King’s College London and Imperial College London used diffusion MRI – a type of imaging which looks at the natural diffusion of water – to observe the maturation of the cerebral cortex where much of the brain’s computing power resides. By analysing the diffusion of water in the cerebral cortex of 55 premature infants and 10 babies born at full term they mapped the growing complexity and density of nerve cells across the whole of the cortex in the months before the normal time of birth.
They found that during this period maturation was most rapid in areas of the brain relating to social and emotional processing, decision making, working memory and visual-spatial processing. These functions are often impaired after premature birth, and the researchers found that cortical development was reduced in preterm compared to full term infants, with the greatest effect in the most premature infants. When they re-examined the infants at two years of age, the preterm infants with the slowest cortical development performed less well on neurodevelopmental testing, demonstrating the longer-term impact of prematurity on cortical maturation.
Professor David Edwards, Director of the Centre for the Developing Brain at King’s, based at the Evelina Children’s Hospital, said: ‘The number of babies born prematurely is increasing, so it has never been more important to improve our understanding of how preterm birth affects brain development and causes brain damage. We know that prematurity is extremely stressful for an infant, but by using a new technique we are able to track brain maturation in babies to pinpoint the exact processes that might be affected by premature birth. Here we have used innovative ways to understand how the development of the cerebral cortex is affected.
‘These findings highlight a key stage of brain development where the neurons branch out to create a complex, mature structure. We can now see that this happens in the latter stages of development that would usually take place in healthy babies when they are still in the womb. This suggests that premature birth can interrupt this vital developmental process. It may explain why we sometimes see adverse effects on brain development in those born only slightly prematurely as we now know that this process is happening right up to the normal time of birth. With this study we found that the earlier a baby is born, the less mature the cortex structure. The weeks a baby loses in the womb really matter.
‘These new techniques we’ve developed to identify these crucial processes will allow us to examine how disruption caused by premature birth can lead to conditions such as autism and learning difficulties. We will also use the technique in future studies to test new treatments to prevent brain damage. It’s an extremely exciting step forward.’
The study was funded by: the Medical Research Council; the Engineering and Physical Sciences Research Council; the National Institute for Health Research (NIHR) Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation trust and King’s College London; and the NIHR Biomedical Research Centre at Imperial College London. Infants involved in the study were being cared for in the Neonatal Intensive Care Unit at Queen Charlotte’s and Chelsea Hospital.
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Centre for the Developing Brain at King’s College London
The Centre brings together researchers from King’s College London and clinicians from Guy’s and St Thomas’, as part of King’s Health Partners Academic Health Sciences Centre. The team also works collaboratively with colleagues around the world, particularly with Imperial College London.
The Centre is based at the Evelina Children’s Hospital at St Thomas’ Hospital. It is home to a state-of-the-art MRI scanner, used for research aimed at reducing the number of children who suffer brain damage in the perinatal period through:
• Understanding human brain development around the time of birth
• Creating new capabilities to map cerebral development in health and disease
• Exploring and exploiting the underlying biology of brain development disorder to create new therapies
• Conducting clinical trials of novel neuroprotective and neural rescue therapies – members of the Centre helped to show that cooling babies who had been deprived of oxygen during labour as soon as they were delivered minimises brain damage; this is now standard practice around the world.