03:17pm Sunday 25 August 2019

Fast-acting mothers' milk for healthier babies

The research helps to explain why babies who are exclusively breastfed have fewer infections.

In a paper published in the journal Clinical and Translational Immunology, lead author UWA’s Assistant Professor Foteini Hassiotou and her colleagues from UWA and University Freiburg in Germany show how the number of immune cells (leukocytes) in breastmilk changes during the course of breastfeeding as well as in response to maternal and infant infection.

The team recruited 21 breastfeeding mothers and their babies at different stages of lactation, from a few days after birth to several years into lactation.  The researchers first established the normal range of leukocytes in the milk of healthy mothers and babies.  They then found that the leukocytes in breastmilk increased rapidly when either the mother or her baby had an infection and returned to normal levels when the infection was over.  Remarkably, this response was also seen when only the baby had an infection and the mother was asymptomatic, reinforcing the importance of breastfeeding for the protection of the baby.

“In places where families don’t have ready access to medicine, particularly developing countries, breastfeeding may be a determining factor in infant recovery and survival,” the study authors write.

“Formula doesn’t offer this protection and the ability to adjust to infant needs.

“These findings present new information that is relevant to updating public policy on early infant nutrition that maximises immunological development and protection.  At the same time, they offer new grounds for examining the mechanisms behind the very low rates of symptomatic HIV and cytomegalovirus disease in infants exclusively breastfed by infected mothers.”

The study also found that exclusive breastfeeding was associated with a higher baseline level of leukocytes in breastmilk under healthy conditions.  This may be because of the overall suckling time on the breasts and suggests that babies that are not exclusively breastfed receive not only lower breastmilk volumes but also breastmilk that contains fewer leukocytes.

Assistant Professor Hassiotou and her colleagues point out that the human lactating breast is the only metabolically significant organ of the body for which a medical test does not exist – yet cow’s udders are often tested.  The measurement of breastmilk leukocyte levels now provides a new diagnostic tool for the health of the lactating breast and of the breastfed infant.

Media references

Assistant Professor Foteini Hassiotou (UWA School of Chemistry and Biochemistry, School of Anatomy, Physiology and Human Biology)  (+61 8)  6488 4429
Janine MacDonald (UWA Public Affairs)  (+61 8)  6488 5563  /  (+61 4) 32 637 716

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