10:15pm Tuesday 13 November 2018

Stress during pregnancy related to infant gut microbiota

For the purposes of this study, the stress and anxiety levels of pregnant women were measured by means of questionnaires and testing the levels of the hormone cortisol in saliva. In addition, faeces samples from 56 babies were tested from 7 days until 4 months after birth. A correlation was found between the mothers who reported high stress levels and presented high cortisol levels and the variety of microbiota in the babies’ guts, even when the analyses took breastfeeding and postnatal stress into account.


Different mix of bacteria

Mothers who reported high stress levels and presented high cortisol readings had babies with more Proteobacteria and fewer lactic acid bacteria and Actinobacteria in their microbiota. This represents a poor mix of microbiota, which was also reflected in the relationship between the presence of these microbiota and a higher incidence of intestinal problems and allergic reactions among the babies in this research group.


‘We think that our results point towards a possible mechanism for health problems in children of mothers who experience stress during pregnancy. Giving other bacteria would probably benefit these children’s development,’ says Carolina de Weerth, professor of developmental psychology in the Behavioural Science Institute of Radboud University Nijmegen, and corresponding author of the article that will be published in Psychoneuroendocrinology.
The researchers are keen to stress that the clear correlation they discovered should not be confused with a causal link.

More information:
Carolina de Weerth
+31-24-3612637 (secr. 3615550)

Maternal Prenatal Stress is Associated with the Infant Intestinal Microbiota


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