02:13pm Saturday 23 September 2017

An Orange a Day May Keep Stroke at Bay

A new study by researchers at Brigham and Women’s Hospital (BWH) found that citrus fruits may reduce the risk of stroke in women.

The study was electronically published on February 23, 2012 in Stroke, a journal of the American Heart Association.

Kathryn M. Rexrode, MD, BWH Department of Medicine, and colleagues from the University of East Anglia, United Kingdom and the University of Bari, Italy conducted a prospective study of 69,622 women from data from the Nurses’ Health Study. Based on questionnaires participants completed during 14 years of follow-up, the researchers were able to track stroke incidence and calculate flavonoid intake. Flavonoids are a type of antioxidant found in foods such as fruits, vegetables, dark chocolate and red wine.  

The researchers discovered that a particular sub-type of flavonoid called flavanonewhich are abundant in citrus fruitsseemed to have a protective effect against stroke.

High consumption of citrus fruits and juices was associated with a 19 percent reduced risk of ischemic stroke (a type of stroke that happens when blood flow to the brain is blocked). Women who consumed the highest amount of flavanones had a lower risk of ischemic stroke compared to women with the lowest intake. 

Participants’ main dietary sources of flavanones came from oranges and orange juice (82 percent), followed by grapefruit and grapefruit juice (14 percent).

The researchers note that in addition to flavanones, other components in citrus that may reduce stroke risk include vitamin C and potassium.  

Despite the study’s praise for citrus fruits, the researchers caution that more work is still needed to confirm their findings.

“I would certainly not recommend that anyone take flavanone supplements based on this research,” said Rexrode.

If people do consume citrus, the researchers recommend that they reach for an actual orange instead of a box of OJ, since commercial fruit juices tend to be higher in sugar.

Also, people who take medications should be aware that some citrus fruits, specifically grapefruit, can dangerously interact with medicines.

This research was supported by grants from the National Institutes of Health.

Brigham and Women’s Hospital | 75 Francis Street, Boston MA 02115 | 617-732-5500


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