The investigators reported in the August issue of Investigative Ophthalmology & Visual Science that oxidative stress, neuroinflammation and cell death increase over time post-blast, suggesting an ongoing neurodegenerative process. They found that initial outer retinal changes resolved or remained focal, but that inner retinal changes spread from focal regions to the entire retina over time.
The model demonstrates that eye blast trauma causes molecular changes and a decrease in visual acuity within the first month post-blast, despite a lack of obvious eye injury. The response matches the delayed visual deficit in some blast-exposed veterans, suggesting that the mouse model may be valuable for testing new therapeutic options.
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