02:31pm Tuesday 28 January 2020

WHO welcomes approval of a second Ebola vaccine trial in Switzerland

This trial approval means that the vaccine will be tested on approximately 115 volunteers in Geneva. The trial, which is receiving support from WHO, is the latest in a series of trials involving 2 different candidate Ebola vaccines that are ongoing in Switzerland, Mali, the United Kingdom, and the United States.

About the vaccine

The experimental VSV-ZEBOV vaccine has been developed by scientists at the Public Health Agency of Canada . It is based on the virus that causes vesicular stomatitis, a disease affecting animals. This virus has been weakened and genetically modified to express the glycoprotein of the Zaire Ebola virus (ZEBOV) so as to provoke an immune response against real Ebola viruses.

The experimental vaccine will be tested on healthy volunteers, some of whom will be deployed as health care staff in the fight against the Ebola epidemic in West Africa. The trial will test the safety of the vaccine and its ability to provoke an immune response. VSV-ZEBOV is also being tested on healthy volunteers in the USA (the first trial started 13 October) and trials are planned to start very soon in Germany, Gabon and Kenya.

Vaccine trials

The trial is the second one organised in Switzerland and coordinated by WHO. The first vaccine, “ChAd3″ – Chimpanzee-Adenovirus ChAd3-ZEBOV – started trials in Lausanne at the end of October.

“These trials show an almost unprecedented mobilisation on the part of countries, health agencies and industry to pitch in and help to curb the Ebola epidemic,” says Dr Marie-Paule Kieny, Assistant Director-General for Health Systems and Innovation at WHO. “If the vaccines prove to be safe and effective and we move to production and distribution scale-up, this will be the fastest vaccine roll-out we have had in response to a public health emergency to date.”

The trial in Geneva begins with the first vaccinations during the week of 10 November, with first results expected in December 2014.


WHO media contacts:

Fadéla Chaib
Communications Officer, World Health Organization
Telephone: +41 22 791 32 28
Mobile: +41 79 475 55 56
E-mail: chaibf@who.int


Tarik Jasarevic
WHO Department of Communications
Telephone: +41 22 791 50 99
Mobile: +41 79 367 62 14
E-mail: jasarevict@who.int


Margaret Harris
Telephone: +41 22 791 1646
E-mail: harrism@who.int


Lausanne media contact:


E-mail: Olga.De-Santis@hospvd.ch@who.int

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