Newborn jaundice can be treated with filtered sunlight, providing a safe, inexpensive, low-tech solution to a health problem that now causes permanent brain damage or death in more than 150,000 babies in developing countries each year.
That’s the finding of a new study by researchers at the Stanford University School of Medicine and their colleagues that will be published Sept.17 in The New England Journal of Medicine. In the study, conducted in Nigeria, some mothers and babies sat under outdoor canopies that filtered out harmful wavelengths from sunlight, but still allowed jaundice-treating blue wavelengths to reach the babies’ skin. The filtered-sunlight treatment was as safe and effective as the blue-light lamps traditionally used to treat infant jaundice.
“This research has the potential for global impact,” said the study’s senior author, David Stevenson, MD, the Harold K. Faber Professor in Pediatrics and senior associate dean for maternal and child health at Stanford. “All babies can get jaundice. In settings with no access to modern devices, we’ve shown we can use something that’s available all around the planet — sunlight — to treat this dangerous condition.” Stevenson also directs the Johnson Center for Pregnancy and Newborn Services at Lucile Packard Children’s Hospital Stanford.
Jaundice is extremely common in newborns, whose bodies need a few days after birth to develop the enzymes that enable excretion of bilirubin, a compound released during the normal breakdown of red blood cells. If too much bilirubin builds up in the blood, the skin and eyes acquire the hallmark yellow tinge of jaundice. Worse, high bilirubin levels can cause lasting brain damage or infant death.
Filtering out ultraviolet, infrared rays
Phototherapy with lamps that emit blue wavelengths has been the most prevalent newborn jaundice treatment since the 1960s. But hospitals and health clinics in developing countries often lack the funds, expertise and reliable electricity needed to use the equipment.
The research team built and tested outdoor canopies that used commercially available plastic films to filter out sunburn-causing ultraviolet rays and infrared rays that could make infants overheat. Jaundice-treating blue wavelengths could pass through the filters. The team used different canopies for sunny and overcast days.
“Even with an overcast sky, we still get good light transmission and phototherapy,” said study author Hendrik Vreman, PhD, a senior research scientist in pediatrics at Stanford, who developed, built and tested the canopies.
For a clinical trial, the scientists enrolled 447 infants with jaundice at a large, inner-city hospital in Lagos, Nigeria, of whom 224 were randomly assigned to treatment with filtered sunlight and 223 to conventional phototherapy. Infants received at least five hours per day of their assigned treatment, and were evaluated hourly during treatment for signs of hypothermia, overheating, dehydration and sunburn. Infants treated with filtered sunlight were held in their mothers’ laps under the canopies and could breastfeed while receiving treatment.
New, conventional methods similarly effective
The two therapies worked similarly well: Filtered sunlight was effective on 93 percent of treatment days, and conventional phototherapy on 90 percent of treatment days. The treatments were also similarly safe.
The team is now studying greenhouse-like structures that incorporate the filters. Such structures will allow for filtered-sunlight therapy in locations that are windy, rainy or have colder climates than Nigeria’s.
“We’re excited that we can use our understanding of the biology of jaundice and adapt treatment to the local context of a developing country, and the resources that exist there,” said Stevenson, who is a member of the Stanford Child Health Research Institute.
The study’s lead author is Tina Slusher, MD, associate professor of pediatrics at the University of Minnesota. Another Stanford-affiliated author of the study is Ronald Wong, senior research scientist in pediatrics.
The study was funded by the Thrasher Research Fund and by the National Center for Advancing Translational Sciences of the National Institutes of Health (grant UL1TR000114.)
Stanford’s Department of Pediatrics also supported the work.
Stanford Medicine integrates research, medical education and health care at its three institutions – Stanford University School of Medicine, Stanford Health Care (formerly Stanford Hospital & Clinics), and Lucile Packard Children’s Hospital Stanford. For more information, please visit the Office of Communication & Public Affairs site at http://mednews.stanford.edu.