08:51am Tuesday 14 July 2020

Endogenous "cannabis" influences development of the fetal pancreas

Regulation by unsaturated omega-3 fatty acids
In collaboration with colleagues from Poland, the USA, Italy and Sweden, the team led by Tibor Harkany of the Center for Brain Research at MedUni Vienna successfully demonstrated that endocannabinoids have a direct influence upon pancreatic development in the unborn baby. These endogenous messenger substances are part of the endogenous cannabinoid system and are increasingly recognized as molecular determinants of the development of fetal organs.

The current study highlights a possible risk-effect of these substances, which we have only known for about 20 years: if endocannabinoid levels are perturbed, an increased probability for children to develop difficulties to process glucose could exist – thereby exposing them to a higher risk of developing diabetes. The reason for this is that, during development of the pancreas, endocannabinoids influence both the composition and size of the islets of Langerhans, which produce insulin and glucagon.

It can be a benefit for expectant mothers to take diets enriched in unsaturated omega-3 fatty acids – such as those found in fish oil – to lower not only their own but also their baby’s endocannabinoid levels, which can positively influence the unborn child’s pancreas development.

Nevertheless, since endocannabinoids were discovered at the beginning of the 1990s, these substances, produced by the body itself, have been regarded as “multi-talented”: endocannabinoids control many physiological processes, such as fertility, development of the central nervous system, pain perception, appetite, immune response and even energy metabolism. We can now add to this expanding list that endocannabinoids are also active to “program” the fetal pancreas. “In our tests, we were essentially able to modulate the position of cells making up the islands of Langerhands at will by adding molecules that regulate endocannabinoid signaling. Thereby, we succeeded in growing functional pancreatic island-like cell clusters, at least in culture,” describes lead author Katarzyna Malenczyk.

Tibor Harkany is impressed by the research results: “This new understanding will certainly help us to develop strategies to repair faulty pancreatic development in good time. It will also accelerate the pharmacological development of effective drugs. In my view, the therapeutic potential is vast since our study also shows the exact sequence of processes that promote life-long benefits, particularly improved hormonal responsiveness.”

Service: Proceedings of the National Academy of Sciences of the United States of America (PNAS)
Fetal endocannabinoids orchestrate the organization of pancreatic islet microarchitecture – Katarzyna Malenczyk, Erik Keimpema, Fabiana Piscitelli, Daniela Calvigioni, Peyman Björklund, Ken Mackie, Vincenzo Di Marzo, Tomas Hökfelt, Agnieszka Dobrzyn & Tibor Harkany. Proc. Natl. Acad. Sci. USA, early edition.

Five research clusters at MedUni Vienna
In total, five research clusters have been established at MedUni Vienna. In these clusters, MedUni Vienna is increasingly focusing on fundamental and clinical research. The research clusters include medical imaging, cancer research/oncology, cardiovascular medicine, medical neurosciences and immunology. Research conducted at the Center for Brain Research falls within the remit of the medical neuroscience cluster but, with its endocrinological approach, the above-mentioned study explores new avenues of strategic and interdisciplinary research.

MedUni Vienna

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