7 Best Leaky Gut Supplements – Top Gut Healing Products 2021

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Updated on - Written by
Medically reviewed by Kimberly Langdon, MD

leaky gut supplements

Changing the poor diet is an essential part of restoring your gut, however, from time to time our bodies need an additional push to make sure proper restoration. Taking dietary supplements, like leaky gut supplements can provide you with more support in your therapeutic journey and make a great difference in the health of your gut.

We have prepared a list of the 7 best supplements for healing leaky gut and guidelines products that will help you get started. To show and emphasize the need for leaky gut help aids require lots more research and investigation than embedding a widget of suggested products to try. Instead of simply revealing those leaky gut supplements, we reviewed each one.

Top 7 best Leaky Gut Supplement Brands (August. 2021)

What is Leaky Gut Syndrome?

First, we need to know precisely what this condition is, including its characteristics, nature, and prevention. Many people don’t even know what problems they have with “Leaky Gut Syndrome”.

A leaky gut syndrome[1] is a condition also known as “intestinal permeability,” which refers to a condition in the digestive tract in which protective proteins are damaged. This damage occurs in the “bad” bacteria that enter the intestine, causing system-wide inflammation. This increased permeability leads to the inadequate functioning of the digestive tract (GI), which can have a huge impact on several bodily processes and is a major aspect in the progression of most autoimmune diseases food allergies.

For some reason, many doctors and healthcare professionals do not recognize Leaky Gut Syndrome as a diagnostic problem, despite clear evidence to the contrary.

There are some of the science-based supplements that are recommended to heal leaky gut, including:

  • L-Glutamine
  • Probiotics
  • Vitamin D
  • Digestive Enzymes

Editor’s Choice

Gundry MD Bio Complete 3

Gundry MD Bio Complete 3 

Why is it better?

  • 90-day money-back guarantee
  • 3-pronged formula
  • A healthy blend of Prebiotics, Probiotics, and Postbiotics
  • Research provides scientific support
  • No known adverse effects

Get The Deal

33% Off Exclusively With Our Above Ambassador Link

Read Review Details

The Lineup At A Glance

Most Fast Acting

  • 100% natural ingredients
  • Easy-to-swallow capsules
  • 3rd party lab tested

Get The Deal

30% Off Exclusively With Our Above Ambassador Link

Best Variety

  • GMP Compliant
  • Third-party lab tested
  • Non-GMO

10$ Off Coupon: “HEALTHCANAL10”

Best Potency

  • Clinically Studied Ingredients
  • Preservative-free formula
  • Gluten-free and shellfish-free

Best Purity

  • 2-in-1 immune support formula
  • Non-GMO
  • Manufactured in a GMP-certified facility

Best Flavor

  • Comprehensive blends
  • Plant-based
  • 90-day money-back guarantee

Most Promising Formula

  • Easy Dissolve Formula
  • Artificial Sweetener-free
  • 8 Unique Wellness-Support Blends

7 Best leaky gut supplement brands

Gundry MD Bio Complete 3

Gundry MD Bio Complete 3

Gundry MD’s Bio Complete 3 one of the best leaky gut supplements available today. Bio Complete 3 gut health supplements by Gundry MD is a dietary supplement that includes an exclusive combination of prebiotics, probiotics, and postbiotics to help a healthy digestive tract.

  • 90-day money-back guarantee
  • 3-pronged formula
  • A healthy blend of Prebiotics, Probiotics, and Postbiotics
  • Research provides scientific support
  • No known adverse effects
  • Quite expensive
  • Lacks a clear and transparent ingredient list

Get The Deal

33% Off Exclusively With Our Above Ambassador Link


Bio Complete 3 comes from the fact that the supplement is made up of prebiotic, probiotic, and postbiotic ingredients that support colon health in three different ways. It was formulated by a genuine, experienced medical health practitioner who now runs numerous anti-aging clinics across California. Go ahead and find out more details about the Gundry MD Bio Complete 3 product.

The formula consists of 2 billion CFUs of Bacillus coagulans, 1,000mg of tributyrin, and 200mg of Sunfiber. Together, these substances feed your intestinal bacteria (Sunfiber), support your intestinal microbiome (Bacillus coagulans), and support overall digestion (tributyrin).

While Gundry MD isn’t recognized for its cheap pricing at $ 70, it’s certainly not the cheapest leaky gut formula on this list, the company offers scientifically proven dietary supplements to help with various benefits. Each bottle of Bio Complete 3 contains 120 tablets or 30 servings. You take 4 capsules per serving to help promote digestive health and combat leaky gut

Total Restore by Gundry MD

Total Restore By Gundry MD

Total Restore is an effective supplement developed by Gundry MD, formulated to help people suffering from leaky gut. It is a natural supplement that restores the lining of the gut damaged by the digestive food group.

  • 100% natural and pure ingredients. 
  • Excellent Refund/ return policy
  • Decreased food cravings
  • Fast-acting
  • GMP-certified facility and 3rd-party lab-tested
  • Might not suitable for those allergic to seafood
  • Magnesium and Grape juice can cause some side effects

Get The Deal

30% Off Exclusively With Our Above Ambassador Link


Beside Bio Complete 3, Gundry MD offers various supplements to restore leaky gut, and the next one is Total Restore. Gundry MD Total Restore is a product aimed at people suffering from a condition known as “leaky gut syndrome”, which likely affects most people and causes a huge variety of symptoms.

The formula incorporates more than a dozen ingredients focused on numerous aspects of gut health, including fruit and plant-based extracts, nutrients and minerals, and more. With an emphasis on the gut lining, fatigue, digestive discomfort, and problems associated with weight problems. Supplements combine 16 all-natural ingredients that can help with comfortable joint health and even better manage your food cravings.

Many of the ingredients found in Bio Complete 3 have re-appeared in Total Restore. Apart from the unique ingredient profiles in each Bio Complete 3 and Total Restore, another important difference is that the former acts as a gut support base. Total Restore is offered at a much lower concentration than Bio Complete three. Also, Total Restore comes in a capsule rather than a powder, which can make it extra convenient.

Amy Myers MD Leaky Gut Revive

Amy Myers MD Leaky Gut Revive

Amy Myers MD Leaky Gut Revive is one of several supplements on this list that specifically mention leaky gut in their name. Leaky Gut Revive claims to reduce signs and symptoms of leaky gut by restoring your intestinal barrier, thereby decreasing indigestion, bloating, gas, IBS, and more.

  • No artificial sweeteners
  • Enhanced Immune Function.
  • Cost-friendly option
  • Enhances the gut’s mucosal lining
  • Reduces cravings
  • No flavor to choose
  • Only available online

10$ Off Coupon: “HEALTHCANAL10”


The special thing about this supplement was that it was not developed by a pharmaceutical company but by Amy Myers MD, a real doctor who released a health lineup under AMMD / Amy Myers MD who is familiar with all your problems and inflammatory bowel problems.

Leaky Gut Revive comes in a bottle of bulk powder. You mix the powder with your drink of choice. Dr. Myers recommends a water smoothie or juice in the morning since the powder is flavorless and can be mixed with pretty much anything. According to Dr. Myers, taking it every day can certainly “maintain a healthy gut lining”.

Leaky Gut Revive has an incredibly potent formula with dosages similar to a number of the strongest leaky gut supplements. Each scoop (5.8 g, 30 scoops per container) contains 3,000 mg of L-glutamine and 2,750 mg of a proprietary blend that includes licorice root powder, marshmallow root powder, aloe Vera leaf, and smooth elm bark powder Ingredients that combine supplements.



GutMD is one of the hundreds of gut supplements available online. 1MD GutMD was developed by a gastroenterologist, Dr. David Kahana, formulated by a doctor, and contains quality-tested and proven ingredients. With this, experts claim to have conceptualized this prescription which he insists, “designed to enhance the function and health of the intestinal lining”.

  • Free shipping on all orders
  • Discounts provided for bulk purchases
  • Highly Potent
  • Clinically Studied Ingredients
  • Expensive
  • Limited payment options


GutMD is a nutritional supplement designed to improve the integrity of the lining of the intestine, immunity, GI tract motility, and absorption of vitamins, and is a formula designed to fight a leaky gut.

1MD’s GutMD is a blend of prebiotics that stimulate the growth of healthy bacteria in the gut. The 4 active ingredients of GutMD consist of Gutgard licorice root extract (150 mg), Fibregum acacia fiber (60 mg), CARE4U human milk oligosaccharides (250 mg), and L-Glutamine (1500 mg per 3 capsule servings). These four ingredients are packaged directly in the vegetable cellulose with vegetable oil powder.

These bacteria then improve the gut’s immune function and promote overall health and repair. By taking GutMD daily, you can improve the integrity of the intestinal lining and improve the functioning of the immune system by using four verified ingredients. You can buy 1MD.GutMD online at their official website, where bottles cost anywhere from $42 to $ 50 or depending on how many you buy.

BioTrust Gut Reg

BioTrust Gut Reg

BioTRUST’s GutReg is a 2-in-1 immune support formulation that promotes health in a variety of ways. According to the official website, BioTRUST Gut Reg, directly and indirectly, strengthens the immune system as well as your gut lining

  • 100% 60-days money-back guarantee
  • Non-GMO
  • Manufactured in a GMP-certified facility
  • 3rd party tested safety and purity

  • Not formulated by Doctor
  • Not FDA approved


Gut Reg is certainly considered one of the many leaky gut supplements listed here for the use of L-Glutamine, one of the few ingredients that have been proven in many studies to have a real effect on the GI tract. According to BioTRUST, the L-glutamine in Gut Reg is the main source of energy for enterocytes, which may be the same cells that make up the gut lining and cells of your immune system.

Simplicity is becoming a common trend so far, BioTRUST’s Gut Reg uses four active ingredients to help support gut health and clear up digestive issues. The four active ingredients consist of 500mg L-Glutamine, 250mg of ginger extract, and 75 mg PepZin, which provides 15 mg of zinc. Although not formulated by a doctor, BioTRUST was founded by people who have a solid reputation as a licensed health personality and nutritionist and supplement expert respectively.

Unify Health Labs Multi-GI 5

Unify Health Labs Multi-GI 5

Multi-GI 5 is a digestion-boosting supplement that makes use of 12 gut-health boosters. By taking one scoop of powder daily, you can purportedly support weight control, healthy digestion, a balanced gut flora, and energy.

  • Reduce sugar cravings
  • 90-day money-back guarantee
  • Independent 3rd-party facility
  • Great flavor taste

  • Shipment takes 15-20 days
  • Some reviews claim side effects that include diarrhea


Multi-GI 5 is a gut health supplement manufactured by Unify Health Labs, which you bought online for $ 70 per bottle. The former American Idol Judge Randy Jackson launched Unify Health Labs to share his holistic health technique with the world. Today the Los Angeles-based company makes some top-notch nutritional supplements that focus on numerous health goals.

Unify Health Lab aims for gut health in three ways using three formulas. It combines probiotics, prebiotics, and a complementary blend for digestive health. A total blend of different ingredients, giving you “all-round health support consistent with Unify Health Labs.

With that said, many of the ingredients found in the GI blend resonate with others, in particular, the 433mg GI blend combines L-Glutamine, Deglycyrrhizinated Licorice DGL Root Extract, ProDURA, and Zinc-Carnosine Complex. Like any other supplements, Multi-GI 5 is quite expensive although a few are inclined to pay a higher price for a high-quality level.

ActivatedYou Morning Complete

ActivatedYou Morning Complete

Activated You Morning Complete is a supplement that contains essential nutrients designed to improve your body function. With a combination of 8 proprietary formulas, which contain probiotics, superfoods, and veggies, Morning Complete by ActivatedYou claims to deliver all-in-one health.

  • 90-days money-back guarantee
  • Great flavor
  • A unique blend of ingredients

  • Some customers report side effects.
  • Newly company


ActivateYou is a new specialty supplement company, focused on holistic nutrition. Currently, the Company’s line of supplements has few products, and it is clear that Morning Complete is its flagship product.

With 10 billion CFUs per serving and a healthy dose of extra fiber. ActivatedYou Morning Complete is a respected leaky gut supplement that needs to support digestion in several ways. At $ 80 for 30 servings (30 scoops). ActivatedYou Morning Complete is one of the most expensive leaky gut nutritional supplements on this list, even though they also have a larger scoop size (7.6g per scoop) than most other formulas.

Besides, Morning Complete is said to relieve bloating, gas, and various digestive problems. It is said to provide a selection of ingredients that impart incredible nutritional value. It also emphasizes the significance of its leafy green extracts – something we don’t see in various leaky gut dietary supplements. These ingredients can support your body with oxidative stress factors, support healthy liver and cell function and, among other things, support healthy blood sugar levels.

“Must-have” supplements for leaky gut 


L-glutamine[2] promotes the healing of the intestinal lining, makes it possible to repair the damage of the intestine, and helps to reverse the damage caused by the leaking intestine syndrome. This may be due to its anti-inflammatory properties. Unnecessary and/or persistent infection is the main cause of intestinal and physical stress, which may eventually lead to the development of harmful conditions and diseases.

Because L-glutamine is the main source of fuel for cells that build up the gut, one must have enough of the availability of these important amino acids, and fatty acids. Keeping cells allows you to help you avoid intestinal diseases and stress.


Các chất bổ sung Probiotics [3] thường có thể được tối ưu hóa cho nhu cầu cá nhân tùy thuộc vào chủng mà bạn có thể tùy chỉnh mức tiêu thụ của mình để đạt được hiệu quả chữa bệnh tối đa. Một trong những yếu tố lớn nhất để duy trì sức khỏe ruột tốt là duy trì sự cân bằng vi khuẩn chính xác. Ruột của chúng ta chứa đầy vi khuẩn tốt giúp chúng ta phân hủy và tiêu hóa thức ăn đúng cách. Chúng giúp duy trì thành ruột của chúng ta để kiểm tra và ngăn chặn vi khuẩn “xấu” phát triển quá mức.

People with less probiotic representation in their system regularly experience an overabundance of bad bacteria that can be devastating to the gut. Common probiotic reducers include antibiotics, steroids, acid blockers, and a bad diet.

Vitamin D

Vitamin D[4] was first discovered about a century ago, but researchers are still learning about all the ways, which can benefit people today. During those findings, the researchers found that the use of this vitamin is useful for customers who have a leaky gut, based on studies on animals.

Finally, ensuring that sufficient vitamin D has been given to the person has been validated to balance the bacteria in the small intestine, decrease the chances of intestinal lining infection, prevent inflammation and reduce symptoms associated with autoimmune diseases.

Digestive Enzymes

One way to fight intestinal leaks is through the use of digestive enzymes. Digestive enzymes[5] are microbial or plant-based dietary supplements that aid the absorption, breakdown, and utilization of macronutrients.

In a style similar to that of probiotics, digestive enzymes help to perform specific bowel functions. Some meal sensitivities such as dairy products, soy, and gluten can be completely or partially alleviated through proper enzyme supplementation.

Symptoms of Leaky gut syndrome

The researchers[6] found that each of the following was expected to show signs and symptoms of Leaky Gut Syndrome. Since leaky gut syndrome is often caused by digestion problems, the most common are the signs of the gut. These include:

  • Gas and bloating
  • Food allergic reactions
  • Constipation or Diarrhea
  • Inflammatory bowel disease colitis, and Crohn’s disease
  • Heartburn or reflux

Many of those signs and symptoms and digestive disorders are associated with excessive growth of bacteria or various microorganisms, and also the inflammation of the intestine that they cause. This irritation of the lining of the gut may be a major cause of the symptoms of the leaky gut.

However, since the leaky gut allows undigested food particles and unhealthy bacterial fragments into your blood, symptoms can also occur elsewhere in the body, as your immune system attempts to remove intruders. Symptoms outside the digestive tract were also attributed to leaky gut syndromes such as autoimmune reactions, Neuropsychiatric conditions, Skin conditions, Infections, Joint and muscle issues.

Benefits of Leaky gut supplements

Our body needs essential enzymes, natural probiotics, and many extra natural chemicals to maintain our digestive system to the most desirable health. Dietary supplements for leaky gut work in different ways. Most are prebiotics, prebiotics, natural extracts, and many components. Some detoxify your body with antioxidants to help with intestinal inflammation and others and help your gut microbiome.

However, it is essential to be aware that there are different strains, and each naturally made strain of probiotic organisms have distinctive roles. Benefits of probiotics are normally used for the treatment of gastrointestinal (GI) regular health and improve digestive issues and gut health.

Probiotics will absorb nutrients from food and help fight harmful bacteria known for causing digestive health problems, making it one of the best stomach enzymes you can buy.

Potential SIde effects

Dietary supplements with leaky gut have not been associated with significant side effects in any major study when taken at regular doses by healthy adults. With almost every supplement, you should think about the side effects in advance. When scouring some of the resources, customers who have taken leaky gut dietary supplements have identified including:

  • Diarrhea
  • Constipation
  • Bloating
  • Exhaustion
  • Headaches

These are considered normal only because the body needs to adapt to newcomers. If for some reason individuals face serious health implications, the leaky gut supplements should be discontinued. However, follow the recommended dosage instructions and talk to your doctor before taking a leaky gut supplement

How to naturally heal leaky gut?

There is no specific treatment, reducing inflammation in your digestive system is the most effective treatment. Leaky Gut Syndrome has many potential causes, while it is necessary to understand what a leaky gut and intestinal permeability mean, and studying its root causes, even more, it is important to study the method of natural healing your gut.

As critical as understanding what is not to be eaten is knowing which foods promote gut healing. These are some clean lifestyles and modifications to the weight-reduction plan that all people can do Healthy Diets and Nutrients include:

  • Drink 8-10 glasses of water to support your digestion
  • Support your good bacteria with prebiotics.
  • Cook fruits and vegetables as opposed to eating them raw
  • Eat probiotic foods like yogurt, kombucha, to increase the variety of healthy gut bacteria
  • Follow an anti-inflammatory diet
  • Increase your vitamin D intake.
  • Eat up more zinc to protect your intestinal barrier

In addition to making dietary changes, some lifestyle measures can help gut healing. As with dietary changes, these suggestions are designed to keep the digestive system moving easily to avoid inflammation such as:

  • Reduce stress
  • Exercise regularly
  • Take a walk after eating
  • Quit smoking
  • Take probiotics and prebiotics 

Dosage for leaky gut

Leaky gut dietary supplements include significantly different doses among formulas, therefore, you must comply with the recommended dosing on your particular leaky gut supplement. Studies show that substances such as L-glutamine can be useful in doses of 500mg to 1,500mg. However, more studies are needed before you understand a dose of any standard ingredients in leaky gut formulas.

It is also important to keep in mind that colony-forming units (CFUs) are not as important as you think. An excessive number of CFUs is not always consistently better. It is based on the quality of probiotics and their delivery mechanism. In some cases, a 2 billion CFUs supplement can also provide more active bacteria on your digestive tract than a 50 billion CFUs supplement.

Final Thought

While all of these supplements can be useful in healing leaky gut, it doesn’t mean you need to use all of them to heal your leaky gut. Before deciding to buy a probiotic supplement, you must do some research to learn more about the product, its quality, and how it works.

It’s important to be aware that such dietary supplements are not intended to cure or treat a disease, but rather to alleviate symptoms and act as a motivator towards a healthier gut and gut lining. As shown above, our best recommendations have been subtle by considering several factors. For now, they’re always the best solution when it comes to improving gut health.

As for treatments, again, a doctor’s opinion is number one, followed by additional support such as dietary supplements for a leaky gut. The beauty of these dietary supplements is that they all tend to many problems through special lenses, therefore one’s health condition and goals should be assessed before making a purchase.

Frequently Asked Questions

What is the best supplement for leaky gut?

As we mentioned above, our best supplement for leaky gut is Bio Complete 3 by Dr. Steven Gundry

What is the fastest way to heal a leaky gut?

The recovery time for leaky gut varies greatly depending on the condition and its causes. Experts recommend that you can help a leaking gut within 2 to 12 weeks. Some experts recommend removing products based on wheat, gluten, whole grains, processed foods, alcohol, junk or snack foods, and artificial sweeteners from your food regimen to give your body the best chance of improving its leaking gut lining. Although a few leaking gut problems may be more or far less serious.

What heals a leaky gut naturally?

Although there is no specific treatment, reducing inflammation in your digestive system is one of the most effective treatments, by taking a healthy diet, and nutrients, also making some lifestyle changes listed above.

Do leaky gut supplements work?

Dietary supplements for leaky gut work in different ways. Most include prebiotics, prebiotics, natural extracts, and various ingredients. Some detoxify your body with antioxidants to help with intestinal inflammation, and others help your gut microbiome.

+ 6 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Camilleri, M. (2019). Leaky gut: mechanisms, measurement and clinical implications in humans. Gut, 68(8), 1516–1526. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790068/
  2. Hall, J.C., Heel, K. and McCauley, R. (1996). Glutamine. British Journal of Surgery, 83(3), 305–312. Available from: https://pubmed.ncbi.nlm.nih.gov/8665180/
  3. Wilkins T;Sequoia J (2017). Probiotics for Gastrointestinal Conditions: A Summary of the Evidence. American family physician, 96(3). Available from: https://pubmed.ncbi.nlm.nih.gov/28762696/
  4. Yamamoto, E.A. and Jørgensen, T.N. (2020). Relationships Between Vitamin D, Gut Microbiome, and Systemic Autoimmunity. Frontiers in Immunology, 10. Available from: https://pubmed.ncbi.nlm.nih.gov/32038645/
  5. Ianiro, G., Pecere, S., Giorgio, V., Gasbarrini, A. and Cammarota, G. (2016). Digestive Enzyme Supplementation in Gastrointestinal Diseases. Current Drug Metabolism, 17(2), 187–193. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923703/
  6. Arrieta, M.C. (2006). Alterations in intestinal permeability. Gut, 55(10), 1512–1520. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1856434/

Written by:

Healthcanal Staff

Medically reviewed by:

HealthCanal Editorial team is a team of high standard writers, who qualified the strict entrance test of Health Canal. The team involves in both topic researching and writting, which are under supervision and controlled by medical doctors of medical team.

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