08:54am Thursday 27 February 2020

UPMC Surgeons Create 3-D Models to Prepare for Complex Face Transplants

Because face transplantation surgery is medically complex, imaging plays a major role in selecting patients, planning donor and recipient surgery and assessing postoperative motor and sensory function.

By combining information from multiple imaging exams and creating a sophisticated 3-D computer model, surgeons will be better able to assess the facial structure and contours, the underlying bone, muscles, nerves and vessels, as well as the full extent of the damage of a face transplant candidate.

Using integrated information from different imaging exams of sample patients, including 3-D CT, CT angiography, MRI and high-definition tractography, UPMC researchers developed a protocol for a 3-D model that shows a patient’s head and neck anatomy. This same type of modeling technology often is used in movies to animate computer-generated characters with detailed three-dimensional human features and facial expressions. “While there have been some fusions of imaging techniques before, this is the first time anyone has combined so many imaging techniques in a user-friendly model that can be manipulated for detailed face transplant planning,” said Darren Smith, M.D., resident, UPMC Division of Plastic and Reconstructive Surgery.

“We are integrating data from multiple imaging sources into a single 3-D representation that allows for real-time user interaction and modification,” added Dr. Smith. “In assessing eligibility for face transplant surgery, it is critical to understand whether the patient has enough blood vessels and bone structure to support new facial tissue. This 3-D modeling will help us customize the procedure to the patient’s individual anatomy so that the donor tissue will fit like a puzzle piece onto the patient’s face.”

Using this approach, the team overlaid the computerized patient model with a polygon mesh of a generic human face and customized it to the recipient’s facial anatomy. Dr. Smith said the ability to manipulate this 3-D facial envelope allows the entire surgical team to participate in planning exactly where bone, blood vessel and nerves will be cut and connected, as well as to evaluate the outcomes of reconstructive transplantation, including nerve regeneration within the transplanted tissues.

Co-authors include Vijay Gorantla, M.D., Ph.D., and Joseph Losee, M.D., both from UPMC.

Follow this hyperlink to view a video of UPMC’s Dr. Darren Smith discussing new 3-D imaging model for face transplant surgery preparation.

In 2010, UPMC became the third health system in the United States to gain approval to perform face transplants under an experimental research protocol. UPMC is seeking participants with significant facial injury, trauma, deficits or deformities to enroll in its face transplant study. Patients must be between the ages of 18 and 65 and have tissue structure damage including, but not limited to, mid-face structures such as the eyelids, nose and lips.

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