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Best CBD Oil For Seizures – Top 5 Wonderful Options

Every day we are bombarded by external stimuli – lights, sounds, traffic, noise, you name it. And, our body processes all of these stimuli through the central nervous system coordinating the signals into a symphony of sounds and visions that make sense to us.

Our central nervous system coordinates all of this stimuli through communication with electrical impulses transmitted through neurons, which are cells that make up the brain. This system usually functions quite well, but when it doesn’t, that is when a seizure can happen. A seizure is an uncontrolled electrical impulse in the brain. It is literally a brainstorm of electrical activity.

CBD for Epilepsy

CBD can help treat various health problems, with the best CBD oil can be found here. While many drugs can treat epilepsy, none are known to prevent its development. A third of people with epilepsy remain resistant to their medications. This leaves them open to increased risk of sudden unexpected death from epilepsy-related seizures or impairments in psychosocial, behavioral, and cognitive functions. This resistance to traditional medications makes CBD products very appealing as an alternative treatment modality.

The interaction between CBD and other epileptic medications is unknown and may be responsible for the elevated liver enzymes seen in some studies of Epidiolex[1](FDA’s approved CBD drug for epilepsy). However, such adverse effects were not severe and precautions were issued with recommendations to monitor the liver enzymes and concurrent medication levels while using CBD. Otherwise, CBD is generally considered safe, non-psychoactive, with few side-effects. 

Editor’s Choice

Take Spruce CBD

Spruce CBD

Why is it better?

  • Full-Spectrum
  • Vegan and gluten-free
  • Top-quality

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The Lineup At A Glance

Best quality

  • GMO free
  • Natural flavoring
  • CO2 extraction

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Best technology

  • GMO-Free
  • Nanotechnology
  • Wide range of products
  • Zero THC

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Best variety

  • CO2 extracted
  • Full spectrum oil
  • MCT oil derived from coconuts

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Most natural

  • GMO free
  • Zero pesticides

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Top 5 Best CBD Oil for Seizures Reviews 2020

Spruce CBD

Take Spruce CBD

Spruce is a family-owned business that offers high quality full spectrum hemp oil made without pesticides and zero high.

  • Vegan free
  • Gluten free
  • Full-spectrum
  • Cost higher than average
  • Only two potencies to choose from

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The products are all third-party lab tested and certified for purity of ingredients. It is unique in that it uses an alcohol extraction method rather than CO2, a method just as safe and effective. Spruce have also rated as one of the best CBD brands for several health issues.

The CBD is extracted from hemp that has been bred and cultivated for over 200 years in the U.S. It is grown in Kentucky and North Carolina.

Spruce products are full-spectrum meaning you get the benefits of all the cannabinoids, the terpenes, vitamins and natural flavorings of the original plant it came from. This means you benefit from the entourage effect, a synergistic blending of chemicals that heightens the actions of each other.

The 30 ml peppermint flavored vials come in two strengths: 25 mg CBD per ml (750 mg total) and 80 mg of CBD per ml (2,400 mg total).

The company also provides third-party testing of all of its products guaranteeing safety and quality.

CBD Pure Oil

CBDPure CBD Oil_1

CBD Pure offers affordable products that offer great results in different dosage options.

  • GMO free
  • Natural flavoring
  • CO2 extraction
  • Only 2 forms of products
  • Few flavor options

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This organic farm began in 2016 in Colorado with a mission to provide the best CBD product on the market. The farm does not use any pesticides or herbicides on it’s organic ranch. 

They third-party test all of their products to guarantee freshness and purity to their customers and even provide a downloadable version of their test to any given location.

They are affordable and even offer coupons to help defray expenses. These coupons can be applied at check-out.

The natural flavoring is due to the fact that all of the plant residue was removed during CO2 extraction. It is noticeable in the lack of green tint to the oil and is tasteless in the softgels.

To prove confidence in their product, CBD Pure offers a 100% guarantee on all of its products so that if you are not entirely satisfied you can return the product and get your money back within 90 days.

Joy Organics – Best CBD oil for seizures

Joy Organics CBD Oil

The company prides itself on its transport to all U.S. states and in its freedom from harsh metals, THC and gluten. It is also organic and Farm Bill compliant.

  • GMO free
  • Nanotechnology
  • Wide range of products
  • Zero THC
  • Unclear sourcing
  • Not recommended for vegans
  • Does not offer international shipping

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Joy Organic uses only phytocannabinoid-rich hemp that contains a range of 112 cannabinoids! Most of the CBD oils have some THC in them, but CBD Pure does not have a trace of it in their products. However, the user may still benefit from the entire entourage effect of all 112 cannabinoids!

The products go through a testing process whereby a Certificate of Quality Assurance and a Certificate of Analysis are generated by both in-house testing and a third-party lab. Both of these are indicators of purity and standard of quality.

Joy Organic prides itself on using only the finest U.S. grown hemp. Standards at American hemp farms are higher than those in other countries.

 The oil products come in four flavors, orange, tranquil, natural and mint. Along with the four flavors come four different potentcies, 250, 500, 1000 and 1500 mg per bottle. The oil itself undergoes a process to make it more bioavailable, a technique called nanotechnology emulsion which involves breaking down the molecule into smaller, more digestible components.

The company does not charge for its shipping fees, thus saving the customer valuable money.

CBDfx

CBDfx-Tincture

This innovative company, which started in 2015, hosts a wide variety of products which it sells nationally and internationally.

  • CO2 extracted
  • Full-spectrum oil
  • MCT oil derived from coconuts
  • Important information not readily available
  • Returns are not convenient

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CBDfx extracts its oils from hemp grown in Europe or Kentucky where it is then shipped to southern California for further processing.

CBDfx uses organic farming techniques and CO2 extraction to guarantee the finest CBD oils it can produce. CO2 is widely considered the safest option for extraction of hemp.

Being full-spectrum, you are guaranteed the entourage effect so vibrant in the function of CBD. Full-spectrum means you have the advantage of the terpenes, flavonoids and all the cannabinoids in the oil.

The product line is widely diverse from those supplements made for pets to those for the rest of us like tinctures, oils, drinkable shots, sublingual strips in fun flavors, and capsules.

Penguin CBD

penguin cbd oil

Penguin CBD is organically grown in the U.S. on an environmentally conscious farm with no pesticides and produces both broad-spectrum and isolate forms of product.

  • Broad-spectrum and isolate
  • Variety of flavors
  • Variety of products
  • Limited strength availability

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Penguin CBD was founded in 2019 in Oregon topping numerous “best of” lists and gathering acclaim from reputable sources. 

They use a broad-spectrum oil meaning you gain all the entourage effects of the cannabinoids, minus the THC. The gummies contain only isolate forms of CBD. CBD isolate contains only CBD, thus, a pure dose of CBD can be administered without the terpenes and other cannabinoids. The softgels also come in isolate form.

The oils come in four flavors and three strengths. Natural, Strawberry, Cookies and Cream, and Mint top the flavor list. The strengths come in 250, 600 and 1000 mg. The supplements come in doses of 15mg-750 mg per 30-tablet bottle. 

There are a wide variety of products to choose from including tinctures, oils, creams, gummies, bath bombs, edibles and capsules.

Does CBD Oil Help with Seizures?

The current therapy for seizure control fails to control seizures in 30-40% of patients[2], leaving an unmet need for other viable treatment options for this disorder. Not only is there a high failure rate, but the side-effects to classical seizure treatment is often felt to be worse than the seizures themselves. It is no wonder that many people have turned to CBD as a potential, alternative treatment option for epilepsy and seizures.

In research published in Epilepsy & Behavior[2], it was found that those using CBD had reduced seizure frequency and its side-effect profile in only 12 weeks, with the maintenance of results stretching into 24 and 48 weeks. This research study used oil void of THC. 

Research has shown the use of CBD oil to decrease the frequency of treatment resistant epilepsy[3] with Gestalt syndrome by 20% while the rate of decrease in undifferentiated epilepsy is less clear.

How Does CBD Oil Stop Seizures?

CBD restores normal brain rhythms. It does not do this by a direct effect on cannabinoid receptors, however. It acts via the endocannabinoid system. CBD antagonizes the GPR55 receptor at excitatory synapses[4] in the brain and inhibits the chemical messengers thus calming seizure activity. The GPR55 receptor is one of the endocannabinoid receptors involved in CBD communication between cells and are part of the endocannabinoid system. 

CBD desensitizes TRPV1 channels. The TRPV1 channels determine how your body experiences pain and are located throughout your central nervous system and brain. People who have epilepsy have more TRPV1 receptors in the temporal lobes of their brains than those who do not have epilepsy.

CBD inhibits nucleotide transporters reducing adenosine updates. In the brain, adenosine is a CNS depressant, an inhibitory neurotransmitter. It is essential for the proper functioning of every cell in the body. Research shows us that adenosine receptors are powerful for regulating seizures in epilepsy[5].

CBD Treatment for Seizures

The two main cannabinoid treatments for seizure are THC and CBD. The Food and Drug Administration (FDA) only recognizes Epidiolex, a purified CBD isolate, as an approved form of treatment for two forms of epilepsy, Dravet Syndrome & Lennox Gastaut Syndrome (LGS). Gastaut Syndrome and Dravet Syndrome[6] are each a form of epilepsy where using CBD has been shown to make a significant positive difference for many people.

Gastaut Syndrome and Dravet Syndrome are severe refractory forms of epilepsy that begin in childhood and are resistant to most treatment. Current available treatments fail to control seizures in most cases thus making the identification of new medications necessary.

Some research has shown CBD-rich extracts performed better than purified CBD[7] in treatment resistant epilepsy. Patients using the extracts used a lower dose than that for purified CBD and reported fewer side-effects. This study[7] concluded that CBD extracts had a better therapeutic profile than did purified CBD in treatment resistant epilepsy.

According to conflicting research, pure CBD products may be the ideal candidate for treatment resistant epilepsy[8] therapy. It is believed to calm seizures by normalizing brain rhythms through a cascade of events. The true mechanism remains unclear[9], however, and some of the research is contradictory.

Epidiolex is pure CBD, with no THC added. CBD has no “high” associated with it, as THC does. FDA currently allows CBD products for sale with up to 0.3% THC in it as a full-spectrum product. Research shows THC can have both seizure-promoting[10] and anti-seizure activity making its use as a drug for seizure control more conflicting.

CBD Oil for Non-Epileptic Seizures

Epilepsy is the most common pathology of the brain[11] accounting for 1% of the worldwide burden for this disease. Diagnosis can be difficult and would be made easier if a reliable set of biomarkers for this disease could be agreed upon. Though seizures are characteristic of all types of epilepsy other common symptoms may include muscle jerking, staring, loss of consciousness, weakness, and anxiety.

Animal research has shown CBD is effective at reducing seizures regardless of the cause[12] or type of epilepsy making CBD oil attractive for possible use in non-epileptic seizures such as seizures caused by increased inflammation or drugs. Oxidative stress can also stimulate seizure activity.

CBD has been shown to reduce inflammatory mediators, thus reducing seizure risk. CBD has antioxidant properties, which also aid in the alleviation of oxidative-stress-induced seizure activity.

Furthermore, CBD may reduce free radical generation and metabolism. Free radicals can build up in cells and can cause damage. Most of the harmful effects of oxygen are due to free radical generation.

How to Use CBD Oil for Seizures

CBD oil is a carrier medium mixed with CBD and an oil such as olive, coconut, or other indigestible oil and can also contain other endocannabinoids depending on whether you buy isolated, broad, or full-spectrum products.

Choosing the right oil can be critical to your success in alleviating your seizures. CBD products come in isolate forms devoid of THC and other cannabinoids except for CBD, or as full-spectrum CBD products that contain all the cannabinoids and makes full use of the endocannabinoid system, or as a broad-spectrum CBD product, which contains all the cannabinoids except for THC.

CBD oil used orally is best absorbed by placing under the tongue and holding it there for a time to allow maximal absorption and avoiding the first-pass metabolism through the gastrointestinal tract. There is a large vein located just under the tongue where absorption can start immediately.

CBD products also come in various edible forms or can be smoked in a vape cartridge. It might be noted that FDA has not cleared using CBD for oral consumption[13] despite legalizing its sale and despite a statement from the World Health Organization that the consumption of CBD is safe and not subject to addictive properties.

CBD Oil Dosage for Seizures

Because of the FDA ruling, it is not legal to propose dosages for CBD where we are not dealing with an FDA-approved medical condition attributed to a drug. The only drug to receive FDA approval for the treatment of epilepsy is Epidiolex, a plant-derived source of pure CBD.

Each CBD product contains a different concentration. Read the product instructions to assure you are taking it properly. Talk with a doctor or health professional if you have questions about how to take CBD for specific conditions and, especially if there are any drug-nutrient concerns.

Of interest, in the Epidiolex studies, most patients were treated with doses of CBD between 20-30 mg/kg/day. Establishing dosages for CBD oil that is effective has been challenging due to the lack of human clinical trials in this area. The lack of human trials can historically be blamed on its legality, the difficulties in gaining funding, and limitations of state-to-state transport. Some of this legal red tape is coming to an end with the legalization of hemp and the liberalization of the sale of CBD.

Hemp Oil for Seizures

Hemp derived extract was given to 138 patients for epileptic seizures[14]. Sixty-eight percent of the study respondents reported decreased seizure severity or frequency from the effects of CBD.  About 2/3 reported other effects of CBD such as better sleep and improved alertness. Adverse events were reported by 22% and included diarrhea, fatigue, and increased seizures. 

Cannabis oil may have unwanted levels of THC in it, which, in some studies, has precipitated seizures and caused increased anxiety. Hemp derived oil comes from the agricultural hemp plant, a plant different in composition than the cannabis plant since hemp is bred to contain minimal amounts of THC.

Best CBD Oil for Epilepsy

The research to date points to using CBD as the preferred cannabinoid in the treatment for epilepsy. The addition of THC may increase the risk of seizures and may invoke side-effects not seen with pure CBD. The best CBD oils for epilepsy are the isolates and the broad-spectrum oils, which contain no THC and are the closest in structure to Epidiolex, keeping in mind that more study is needed and this area is still controversial.

Frequently Asked Questions

Are there any side effects to taking CBD?

Although the World Health Organization[15] has cleared CBD of any serious side-effects, clinical trials have shown that as many as 20% of those using CBD may experience low blood pressure, fatigue, dizziness, or diarrhea.  CBD should not be used in pregnancy since animal studies have shown developmental delays and fetal abnormalities. Human studies have not been done in this area.

Can CBD oil make seizures worse?

In some cases, yes; Some studies[16] have shown users of whole hemp-extracted oils had more seizures than prior to using these oils. Users of CBD oils are recommended to keep a symptom diary not only for dose adjustments but to track any adverse events or increase in seizure activity. More clinical trials in this area are needed.

What cannabis strain is better for seizures?

The optimal strains of cannabis for seizures are the ones highest in CBD, such as Charlotte’s Web, Cannatonic, Purple Urkle, Grape Ape, Haleigh’s Hope, and Harlequin.

Can CBD reduce seizures?

Many studies show possible anti-seizure activity by CBD. Although the exact mechanism is unclear, its effects appear to be multifaceted acting on a number of different endocannabinoid targets including the GPR55  and TRVP receptors.

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. EPIDIOLEX is the first and only FDA‑approved prescription cannabidiol (CBD). Available from: https://www.epidiolex.com/
  2. Jerzy P Szaflarskiab, Elizabeth Martina Bebinab, Gary Cutter, et al. 2018. Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study. Available from: https://www.sciencedirect.com/science/article/pii/S1525505018304736
  3. Siri Shaqra, Steven Solum. 2020. Does CBD decrease the frequency of seizures in adults with epilepsy refractory to usual anti-seizure medications?
  4. Kathryn Nichol, Colin Stott, Nicholas Jones, Royston A Gray, Michael Bazelot, Benjamin J Whalley. 2019. The proposed multimodal mechanism of action of cannabidiol (CBD) in epilepsy: modulation of intracellular calcium and adenosine-mediated signaling (P5.5-007). Available from: https://n.neurology.org/content/92/15_Supplement/P5.5-007#:~:text=Results%3A%20CBD%20antagonizes%20GPR55%20at,in%20a%20chronic%20epilepsy%20model.
  5. Susan A Masino, Masahito Kawamura, David N Ruskin. 2018. Adenosine Receptors and Epilepsy: Current Evidence and Future Potential. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026023/
  6. J Helen Cross, Orrin Devinsky, Eric Marsh, Ian Miller, et al. 2017. Cannabidiol (CBD) reduces convulsive seizure frequency in Dravet syndrome: results of a multi-center, randomized, controlled trial (GWPCARE1) (CT.001). Available from: https://n.neurology.org/content/88/16_Supplement/CT.001.short
  7. Fabricio A Pamplona, Lorenzo Rolim da Silva, Ana Carolina Coan. 2018. Potential Clinical Benefits of CBD-Rich Cannabis Extracts Over Purified CBD in Treatment-Resistant Epilepsy: Observational Data Meta-analysis. Available from: https://www.frontiersin.org/articles/10.3389/fneur.2018.00759/full?utm_term=software%20de%20business%20intelligence&utm_campaign[0]=aon&utm_campaign[1]=[Search]%20BI%202018&utm_medium[0]=search&utm_medium[1]=ppc&utm_source[0]=google&utm_source[1]=adwords
  8. Rodolphe Nenerta, Jane B Allendorfera, E Martina Bebin, et al. Cannabidiol normalizes resting-state functional connectivity in treatment-resistant epilepsy. Available from: https://www.sciencedirect.com/science/article/abs/pii/S1525505020304765
  9. Ivan Urits, Kyle Gress, Karina Charipova, et al. 2020. Use of cannabidiol (CBD) for the treatment of chronic pain. Available from: https://www.sciencedirect.com/science/article/pii/S1521689620300458
  10. Olga Malyshevskaya, Kosuke Aritake, Mahesh K  Kaushik, et al. 2017. Natural (∆9-THC) and synthetic (JWH-018) cannabinoids induce seizures by acting through the cannabinoid CB1 receptor. Available from: https://www.nature.com/articles/s41598-017-10447-2
  11. Jerome Engel. 2011. Biomarkers in epilepsy: introduction. Available from: https://www.futuremedicine.com/doi/full/10.2217/bmm.11.62
  12. Pedro H Gobira, Luciano R Vilela, et al. 2015. Cannabidiol, a Cannabis sativa constituent, inhibits cocaine-induced seizures in mice: Possible role of the mTOR pathway and reduction in glutamate release. Available from: https://www.sciencedirect.com/science/article/abs/pii/S0161813X15001229
  13. Scott Gottlieb. 2018. Statement from FDA Commissioner Scott Gottlieb, M.D., on signing of the Agriculture Improvement Act and the agency’s regulation of products containing cannabis and cannabis-derived compounds. Available from: https://www.fda.gov/news-events/press-announcements/statement-fda-commissioner-scott-gottlieb-md-signing-agriculture-improvement-act-and-agencys
  14. Carey Wilson, Taylor Shuman, Matthew Sweney, Colin Van Orman, Francis Filloux. 2018. Artisanal “Hemp Extract” Experience in Utah Epilepsy Cohort: Survey Results (P6.260). Available from: https://n.neurology.org/content/90/15_Supplement/P6.260.abstract
  15. CANNABIDIOL (CBD) Critical Review. 2018. Available from: https://www.who.int/medicines/access/controlled-substances/CannabidiolCriticalReview.pdf
  16. Evan C Rosenberg, Richard W Tsien, Benjamin J Whalley, Orrin Devinsky, et al. 2015. Cannabinoids and Epilepsy. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604191/
Kathy Shattler, MS, RDN
About Kathy Shattler, MS, RDN

Kathy Shattler has been a Registered Dietitian for over 25 years and currently runs her own Telehealth Clinic while freelance writing in her spare time. She graduated with a Master of Science degree in Human Nutrition from Michigan State University and has a plethora of experience in both clinical nutrition as well as public health. She has been deemed a trailblazer in her profession and continues to strive for excellence in public health education in integrative medicine and in her professional writing career.