Best CBD Oil For Anxiety, Depression & Stress – 2022 Brands

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Victor Nguyen

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Medically reviewed by Kimberly Langdon, MD

Best CBD Oil For Anxiety

Everyone experiences anxiety at some point in their life. It may be something small where you panic for a few minutes or something that bothers you for a couple days, but it usually goes away. Sometimes though, the anxiety may last for days or months and it doesn’t improve with time. This could be a sign of an anxiety disorder.

Anxiety disorders are among one of the most common mental health illnesses, affecting nearly 1 in 5[1] American adults. However, less than half of those with an anxiety disorder are being treated. There are many types of anxiety disorders including generalized anxiety disorder (GAD), panic attacks, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), social anxiety disorder (SAD), and many more.

There are a variety of different treatments available for anxiety. One natural alternative to medications is CBD oil. Read on to see how CBD oils can be used, and the best CBD oil for anxiety.

Top 10 CBD Oil For Anxiety List (January. 2022)

  1. CBDfx – Best CBD For Anxiety
  2. Spruce CBD – High Potency
  3. Royal CBD – Best Full Spectrum
  4. Pure CBD – Most Natural
  5. Medterra CBD Oil – Good for Depression
  6. Joy OrganicBest THC-free
  7. Penguin CBD – Best Taste
  8. Savage CBD – Most Flavor Options
  9. Plus CBD – Most Advanced Process
  10. Charlotte’s Web – Best Quality Assurance

CBD for Anxiety

The Food and Drug Administration (FDA) has not approved CBD oils for anxiety treatment. However, there is limited evidence that suggests that people can use CBD safely, with little to no side effects, to help ease symptoms of anxiety. 

In one review[2] of studies where CBD was used in different anxiety disorders, CBD was shown to decrease levels of anxiety in GAD, PTSD, and SAD, and public speaking. While these studies are somewhat small, they show that CBD has some potential benefits in managing many different anxiety symptoms. 

Especially compared to traditional medications which may have many side effects, CBD is a natural alternative option. Read more below to find out how CBD can help anxiety and what products may suit your needs.

Editor’s Choice

Take Spruce CBD

Spruce CBD

Why is it better?

  • Laboratory grade strength
  • High-quality and unique hemp strain
  • Independent lab testing

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The Lineup At A Glance

Best Product

  •  Ethical and sustainable sourcing
  •  CO2 extraction
  •  Third-party test reports available

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Best Full Spectrum

  •  Full spectrum product
  •  Third party tested
  •  CO2 extraction

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Most Natural

  •  Organic and Non-GMO
  •  No flavor additives
  •  Quality tested via third party

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Best Value

  • U.S. Hemp Authority certified
  • Low prices
  • Large pure CBD product selection 

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Best Taste

  • Pesticide-free
  • Organic and GMO free 
  • Many unique flavors

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Best THC-free

  • THC-free products
  • Nan-emulsion technology
  • Broad spectrum

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Most Flavor Options

  • Caters to new and advance users
  • Source from multiple locations for highest quality
  • Large selection of flavors

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Most Advanced Process

  • Transparency from seed-to-shelf
  • EU-certified hemp
  • State-of-the-art testing

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Best Quality Assurance

  • USDA certified organic
  • Full-spectrum
  • Organic

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Top 10 Best CBD Oil For Anxiety

Spruce CBD Oil & Tincture

Take Spruce CBD

Spruce CBD offers some of the most potent cannabidiol (CBD) products on the market due to its lab-grade strength. If you’re looking for a maximum strength product that’s completely natural, Spruce CBD offers a solid line-up of products.

  • Highly potent product made at lab-grade strength
  • Third-party testing reports available
  • Novel moonshine extraction method

  • Expensive
  • Unflavored
  • Limited product selection

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See Full Review Of Spruce CBD


Spruce CBD is considered one of the best CBD oil for anxiety for the strongest products available at 2,400 mg of CBD in a single vial or 80 mg of CBD in one dose. This high quality and high strength product is made from a novel moonshine extraction method to yield some of the best combination of CBD, terpenes, and low THC.

The company is an independently and family-owned business. They get their hemp from family owned farms in North Carolina and Kentucky. Their mission as a business is to provide high-quality alternatives to pharmaceutical products to provide maximum relief.

Royal CBD Full Spectrum CBD Oil

royal cbd official

Royal CBD doesn’t try to sell you an image or a brand but rather trusts in their product quality to speak for themselves. This laser-focus strategy also means they only offer a few different product types.

  • High potency
  • Full spectrum CBD formula
  • Supercritical CO2 extraction
  • Limited product selection
  • Lacking flavor options

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See Full Review Of Royal CBD


Royal CBD products are made using full spectrum hemp extract. The CBD oil tincture is naturally flavored, as is the rest of their product line up. With concentrations up to 2,500 per bottle of CBD oil tincture, they boast one of the stronger products available. However, compared to many other brands, Royal CBD’s inventory is limited as they only carry a total of 10 different products.

Their primary objective is providing the highest quality CBD products without using all the typical marketing bells and whistles seen with other CBD brands. Their website matches this tone as the information comes through plainly and is fairly easily navigable.

CBD Pure Hemp Oil

CBDPure CBD Oil_1

CBD Pure is focused on making all-natural organic hemp products of the highest quality. If you’re looking for a no-nonsense product that delivers in quality, look no further than CBD Pure.

  • Third party lab testing
  • Free shipping
  • Organic and non-GMO
  • Unflavored
  • Limited product selection

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See Full Review Of CBDPure


CBD Pure sources their ingredients from Colorado and Washington farms that are locally-owned. Their quality assurance process ensures that products are made with quality and consistency through Current Good Manufacturing Practices (cGMP). To maintain the purest branding, their products contain no additional additives and are unflavored.

They focus on full-spectrum CBD oil that comes from full spectrum hemp, which means it’s been extracted from the entire cannabis plant. The full-spectrum cbd hemp extract is then combined with unprocessed hemp seed oil as its carrier oil. This is all backed by a money back guarantee of 90 days, where you can return products for a complete refund.

Medterra CBD Tinctures & Capsules

Medterra oil -2

Medterra is a newer company to the United States CBD industry but is starting to set itself apart through its CBD isolate formula in its products.

  • Affordable prices
  • Contains no THC
  • Independently lab-tested
  • Limited product selection
  • Limited flavor options

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See Full Review Of Medterra


Medterra sources their hemp from Kentucky and is U.S. Hemp Authority certified. They pride themselves on the purity of their CBD product, stating that they are free of pesticides, toxins, and THC which can be confirmed by checking the certificate of analysis for each of their products through their website.

Medterra also emphasizes customer service as their website is full of educational content on CBD. They also offer a 30-day money return policy and a rewards program to exchange points for future savings on a purchase.

Penguin CBD

penguin cbd oil

Penguin CBD offers several different delicious flavors across their product lineup. For people who care about how their CBD tastes, give Penguin CBD products a try.

  • Broad-spectrum CBD
  • Flavor variety
  • Free shipping
  • Higher price range
  • Less established brand

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See Full Review Of Penguin CBD


Penguin CBD products are all broad spectrum, which means it contains many different types of cannabinoids. Their ingredients are sourced from Oregon and produced with zero pesticides for a natural and pure CBD product.

Their full spectrum CBD oil comes in 4 strengths: 250 mg, 600 mg, 1000 mg, and 2500 mg per bottle. Other products include CBD gummies, cream, and capsules. Despite a somewhat lackluster variety of products, Penguin CBD makes up for this by their options in flavor offerings, including natural, mint, citrus, strawberry, and cookies and cream. They also offer a monthly subscription so you can save more on your orders by signing up.

Joy Organics CBD Oil Tinctures

Joy Organics CBD Oil

Joy Organics touts itself as the number one zero percent THC, broad spectrum CBD brand available on the market.

  • Nanoemulsion technology
  • THC free CBD product
  • Organic and non-GMO

  • Higher price range
  • No international shipping

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See Full Review Of Joy Organics


Joy Organics CBD products are broad spectrum which offers a variety of cannabinoids and terpenes for achieving full benefits. The company was founded by Joy Smith and her family. The family-owned business offers a large product line-up including CBD oil tinctures, softgels, gummies, and many more varieties.

The organic hemp source of Joy Organics all comes from Colorado. It undergoes CO2 extraction and THC removal, all of which can be verified via third party lab results that are seen directly on the product labels as QR codes for transparency.

CBDfx Gummies

CBDfx Gummies_1

CBDfx is a well-known name in the CBD industry. They are among one of the best in quality and sustainably sourced CBD.

  • Third party lab testing
  • Large product selection
  • Bundles priced for value
  • Limited brand information
  • Clunky web site experience

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See Full Review Of CBDfx


Boasting one of the larger product selections on the CBD market, CBDfx offers everything from CBD oil tinctures and vape juices to topicals such as muscle balm to fask masks. They even offer bottles of capsules that combine CBD with other vitamins and supplements.

The company has been around since 2014 and is known for their high customer satisfaction and support. All of their lab reports are online as part of their website services and also can be found on each individual product label.

Savage CBD Oil Tincture

Savage CBD-1

If you’re new to the CBD scene, Savage CBD offers targeted product selections that are a perfect fit for new users to find out what works best for them.

  • Product transparency and quality
  • Attractive packaging
  • Flavor variety
  • Free shipping
  • No cancellation and strict refund policy
  • Minimal company information

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See Full Review Of Savage CBD


While there isn’t much information available on Savage CBD as a company, we know that Savage CBD has its roots as a vape juice company that transitioned into CBD oil and other products. This means that they offer some of the best vape juices on the market in terms of quality. Their other products include a wide range of options from CBD tinctures, to gummies and lotions.

Savage CBD also boosts their credibility by the transparency provided into each of their products. The website contains lab reports for each individual product and makes it easy for customers to quickly see what their buying is of the best quality that’s been assessed and verified by an independent lab.

Plus CBD Drops Gold Formula

Plus CBD Oil-1

Plus CBD leads the pack in this review for setting new industry standards for safety as the first CBD company to receive the Generally Recognized as Safe (GRAS) designation from the FDA.

  • EU-certified hemp seeds
  • Large selection of products
  • Quality tested in state-of-the-art laboratories
  • Somewhat expensive
  • Limited flavors for some products

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See Full Review Of PlusCBD


Plus CBD markets a large selection of products including their signature CBD oil tincture, gummies, softgels, sprays, balms, and many others. All products are gluten-free, and their hemp is sourced from EU-certified hemp seeds in Europe. The company is based in San Diego, which is managed by a larger, parent company called CV Sciences.

In 2018, they became the first CBD company to receive GRAS status for their Gold Formula CBD Oil. This means that their CBD oil was deemed by experts within the FDA to be a safe addition to supplements and food.

Charlotte’s Web CBD Oil

charlotte's web cbd

As one of the few companies that can claim B corporation certification, you can trust that the company is producing products that are completely natural and of the best purity and quality to advance their mission.

  • U.S. Hemp Authority certified
  • Certified B Corporation
  • Full spectrum formulation
  • Lower concentration than other brands
  • Slightly more expensive

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See Full Review Of Charlotte’s Web


Charlotte’s Web is a CBD company founded by a group of brothers in 2012. It was one of the more recognized brands to date given they are named after the popular hemp strain of the same name. For their CBD oils, they offer strengths from 7 mg to 60 mg per mL of oil.

Other products include gummies, capsules, topicals, and dog treats. Their B corporation status indicates that they are mindful of the environment and social issues with regards to how they run their business, which reflects their brand of transparency and environmental consciousness.

What is Anxiety?

Anxiety is defined as long-term worrying that is difficult to control. Anxiety symptoms can include restlessness, fatigue, difficulty with concentration or sleep, or muscle tension. The World Health Organization (WHO)[3] reported that 264 million people were affected by anxiety disorders in 2015. This number is likely to be even higher today.

As with most mental health disorders, anxiety has many different subtypes such as generalized anxiety disorder (GAD), panic attacks, obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), social anxiety disorder, and many more.

It’s not completely known what causes anxiety but there may be some links to genetics, certain social situations, or environmental factors. Often times there are certain triggers that set off anxiety such as medications, substance abuse, trauma, or certain memories. 

Traditional Anxiety Treatments

Anxiety and depression are often related and can even share similar triggers. Because of this there is a bit of crossover between treatments for anxiety and depression. If you have short-term anxiety, it can be treated with a class of medications called benzodiazepines. Chronic anxiety disorders can be treated with prescription medications, psychotherapy, or a combination of both.

While there are some differences in treatment among different types of anxiety, the majority are similar. According to international guidelines[4], common classes of medications that doctors may prescribe for anxiety disorders are selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs). However, many of these medication classes carry unwanted side effects.

Psychotherapy may also be used for certain types of anxiety. There are many types of psychotherapies available as an alternative to medication. Studies[5] have even shown that using psychotherapy with medications may be extra helpful in improving anxiety issues.

For those who want an alternative to traditional medications and therapies, CBD oil may be an option.

Using best CBD oil for anxiety

Cannabidiol, or CBD, is a naturally occurring compound found in cannabis plants, such as hemp or marjuana. The effects of CBD oils on anxiety has been studied in a limited capacity. Studies have shown that CBD may be effective in helping manage some types of anxiety.

When you take CBD oil, the CBD is absorbed into your body and it interacts with many receptors. One of the major systems it interacts with is the endocannabinoid system (ECS) which contains CBD1 and CBD2 receptors. The ECS helps regulate[6] many bodily functions including fighting off infections and affecting your emotional state.

CBD and tetrahydrocannabinol (THC) are both endocannabinoids, or substances that can affect the endocannabinoid system. Unlike CBD, THC is a psychoactive compound known to cause the “high” effect seen with marijuana. However, CBD oils are derived from hemp, which generally contains less than 0. 3 percent THC. Some CBD oil brands even offer THC-free products.

Is CBD Good for Anxiety?

Due, in part, to the legal history of cannabis, there is limited studies on CBD compared to traditional medication. Researchers and doctors still do not completely know the mechanism behind how CBD helps relieve anxiety. 

Some believe that CBD interacts with the central nervous system which communicates with the brain, as well as certain receptors that have shown the ability to control or affect anxiety-related behavior, including 5-HT1A and TRPV receptors.

A number of animal and human studies have shown that CBD helps alleviate symptoms related to certain types of anxiety:

Is CBD Good for Depression?

Both anxiety and depression fall under the mental health category, and studies have shown that these conditions are often comorbidities[10] of one another. Even with traditional treatments, there are a couple drug classes that can be double-dipped for both conditions, which leads us to CBD.

Similar to most conditions, CBD has not been extensively studied in humans. However, animal models and other small studies[11] have suggested that CBD may have some use in the management of mental health conditions such as anxiety and depression. More studies are needed to confirm if CBD can really be used to help depression, but studies thus far suggests that there is potential use.

CBD Dosage – How Much CBD Oil for Anxiety

Most studies of people using the best CBD oil for anxiety for anxiety issues are single-dose studies in a small sample size. Since CBD products can vary widely in concentration and dosage form, there is no standard dosing for helping ease your anxiety. Make sure to talk with your doctor or healthcare professional if you have questions about taking CBD oils for any reason. Similar to most drugs, it’s safest to start at a low dose and slowly increase it until you find a dose that works best for you. 

Final Thoughts

Cannabidiol oil is a possible natural alternative option to medications for the management of anxiety disorders. Studies have shown that CBD can be safe and tolerable when used in people with anxiety disorders. More studies are needed to show that best CBD oil for anxiety can be effective in managing anxiety long-term.

Frequently Asked Questions

Can CBD be used to help treat anxiety?

Yes, while CBD has not been approved to treat anxiety, some studies have suggested that CBD has anti-anxiety properties. Using CBD, have improved symptoms of anxiety among different subtypes. If you have specific questions about treating anxiety, talk with your doctor.

What is the best CBD oil for anxiety?

The choice for the best CBD oil depends on many factors. No matter the condition, the goal is to find the oil with the best quality. In addition, CBD with a higher potency will offer a greater effect, but that can also increase the risk of side effects. If you have questions about how to take a product, be sure to read the product label or ask your doctor if you have questions.

Will CBD make me high?

CBD is a non-psychoactive compound. It can provide the health benefits of cannabis without the psychoactive effects, or “high”, associated with THC. While some CBD products may contain THC, THC-free products are also available.

+ 11 sources

Health Canal avoids using tertiary references. We have strict sourcing guidelines and rely on peer-reviewed studies, academic researches from medical associations and institutions. To ensure the accuracy of articles in Health Canal, you can read more about the editorial process here

  1. Facts & Statistics. Available from:
  2. Depression and Other Common Mental Disorders Global Health Estimates. 2017. Available from:
  3. Borwin Bandelow, Leo Sher, Robertas Bunevicius, Eric Hollander, et al. 2012. Guidelines for the pharmacological treatment of anxiety disorders, obsessive–compulsive disorder and posttraumatic stress disorder in primary care. Available from:
    in depression and anxiety disorders: a meta-analysis. Available from:
  5. Esther M Blessing, Maria M Steenkamp, Jorge Manzanares, Charles R Marmar. 2015. Cannabidiol as a Potential Treatment for Anxiety Disorders. Available from:
  6. A W Zuardi, J A de Souza Crippa, J E C Hallak, A C Campos, F S Guimarães. 2017. Chapter e13 – The Anxiolytic Effects of Cannabidiol (CBD). Available from:
  7. José Alexandre S Crippa, Guilherme Nogueira Derenusson, Thiago Borduqui Ferrari, et al. 2010. Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report. Available from:
  8. Nora D Volkow. 2015. The Biology and Potential Therapeutic Effects of Cannabidiol. Available from:
  9. Lucas Elms, Scott Shannon, Shannon Hughes, Nicole Lewis. 2019. Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series. Available from:
  10. Femke Lamers, Patricia van Oppen, Hannie C Comijs, et al. Comorbidity Patterns of Anxiety and Depressive Disorders in a Large Cohort Study: the Netherlands Study of Depression and Anxiety (NESDA). Available from:
  11. Jessica W Skelley, Crystal M Deas, Zachary Curren, Jonathan Ennis, 2019. Use of cannabidiol in anxiety and anxiety-related disorders. Available from:
Victor Nguyen

Medically reviewed by:

Victor Nguyen is a licensed pharmacist, having completed his Doctor of Pharmacy at Wayne State. He freelances as a medical writer and reviewer specializing in healthcare articles and web content. His work has spanned from consumer health websites to peer-reviewed journals. In his personal time, he enjoys traveling, cooking, and exploring craft breweries and distilleries.

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